SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vmf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 178
ASP A 199
GLU A 462
TRP A 200
 EDO  A1876 (-3.2A)
MVL  A1865 ( 2.9A)
MVL  A1865 ( 2.8A)
MVL  A1865 (-4.2A)
 1.20A 1mxgA-2vmfA:
7.7		 1mxgA-2vmfA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 11 ILE A 414
VAL A 416
ARG A 507
VAL A 350
ALA A 357
 None
None
EDO  A1869 ( 3.7A)
None
None
 1.21A 1n4hA-2vmfA:
undetectable		 1n4hA-2vmfA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 PHE A 552
SER A 554
LEU A 643
ILE A 394
 None
 0.97A 1sbrA-2vmfA:
undetectable		 1sbrA-2vmfA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 439
ARG A 190
GLN A 418
PRO A 193
TYR A 137
 None
 1.35A 1u70A-2vmfA:
undetectable		 1u70A-2vmfA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 VAL A 262
TYR A 308
THR A 292
LEU A 240
 None
 1.03A 1z2bB-2vmfA:
undetectable		 1z2bB-2vmfA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 217
LEU A 215
LEU A 109
VAL A 141
LEU A 122
 None
 1.23A 2bxfA-2vmfA:
undetectable		 2bxfA-2vmfA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ARG A 216
MET A  34
THR A 214
LEU A  36
 None
 1.37A 2eimJ-2vmfA:
undetectable		 2eimJ-2vmfA:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 714
GLY A 716
ASP A 830
PRO A 785
LEU A 784
 None
 1.07A 2hmyB-2vmfA:
undetectable		 2hmyB-2vmfA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 141
LEU A 215
MET A  34
PHE A 217
GLN A 101
 None
 1.32A 2no0A-2vmfA:
undetectable		 2no0A-2vmfA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 141
LEU A 215
MET A  34
PHE A 217
GLN A 101
 None
 1.29A 2no0B-2vmfA:
undetectable		 2no0B-2vmfA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VZS_A_GCSA1902_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A 199
CYH A 424
GLU A 555
TRP A 645
TRP A 656
 MVL  A1865 ( 2.9A)
EDO  A1876 (-3.3A)
MVL  A1865 (-2.6A)
MVL  A1865 (-3.7A)
MVL  A1865 (-3.7A)
 1.18A 2vzsA-2vmfA:
30.3		 2vzsA-2vmfA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VZS_B_GCSB1903_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A 199
CYH A 424
GLU A 555
TRP A 645
TRP A 656
 MVL  A1865 ( 2.9A)
EDO  A1876 (-3.3A)
MVL  A1865 (-2.6A)
MVL  A1865 (-3.7A)
MVL  A1865 (-3.7A)
 1.18A 2vzsB-2vmfA:
30.2		 2vzsB-2vmfA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ARG A 216
MET A  34
THR A 214
LEU A  36
 None
 1.47A 3ag1J-2vmfA:
undetectable		 3ag1J-2vmfA:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 LEU A 484
TRP A 470
TYR A 488
 None
 1.01A 3aicA-2vmfA:
0.9		 3aicA-2vmfA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 LEU A 484
TRP A 470
TYR A 488
 None
 0.99A 3aicB-2vmfA:
4.4		 3aicB-2vmfA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 LEU A 484
TRP A 470
TYR A 488
 None
 1.00A 3aicE-2vmfA:
4.7		 3aicE-2vmfA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 LEU A 484
TRP A 470
TYR A 488
 None
 1.00A 3aicH-2vmfA:
4.1		 3aicH-2vmfA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ASP A 407
SER A 325
GLU A 323
ASP A  29
 EDO  A1878 (-4.5A)
None
None
None
 1.24A 3bc9A-2vmfA:
8.7		 3bc9A-2vmfA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 LYS A 385
GLY A 359
ARG A 633
LEU A 629
 None
 1.01A 3bjwE-2vmfA:
undetectable		 3bjwE-2vmfA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 LYS A 385
GLY A 359
ARG A 633
LEU A 629
 None
 0.86A 3bjwF-2vmfA:
undetectable		 3bjwF-2vmfA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 LEU A 484
TYR A 488
LEU A 491
LEU A 467
 None
 0.80A 3f33A-2vmfA:
undetectable		 3f33A-2vmfA:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLN A 623
VAL A 773
ARG A 626
LEU A 832
ILE A 856
 BR  A1894 ( 4.8A)
None
BR  A1894 (-4.2A)
None
None
 1.09A 3mnoA-2vmfA:
undetectable		 3mnoA-2vmfA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLN A 623
VAL A 773
ARG A 626
LEU A 832
ILE A 856
 BR  A1894 ( 4.8A)
None
BR  A1894 (-4.2A)
None
None
 1.06A 3mnpA-2vmfA:
undetectable		 3mnpA-2vmfA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_2
(ALPHA-GLUCOSIDASE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 PRO A 159
ILE A 160
TYR A 194
MET A 133
 None
 1.35A 3phaA-2vmfA:
2.9		 3phaA-2vmfA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 TRP A 417
GLY A 641
ALA A 357
PHE A 508
 None
 1.19A 3wqwA-2vmfA:
4.1		 3wqwA-2vmfA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLU A  90
PHE A 156
TYR A 153
HIS A 151
 EDO  A1875 (-3.3A)
None
None
None
 1.05A 4a97A-2vmfA:
3.4		 4a97A-2vmfA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLU A  90
PHE A 156
TYR A 153
HIS A 151
 EDO  A1875 (-3.3A)
None
None
None
 1.03A 4a97D-2vmfA:
undetectable		 4a97D-2vmfA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 GLU A  90
PHE A 156
TYR A 153
HIS A 151
 EDO  A1875 (-3.3A)
None
None
None
 1.08A 4a97E-2vmfA:
3.4		 4a97E-2vmfA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 GLU A  90
PHE A 156
TYR A 153
HIS A 151
 EDO  A1875 (-3.3A)
None
None
None
 1.02A 4a97J-2vmfA:
undetectable		 4a97J-2vmfA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 GLY A 398
ARG A 211
GLU A 440
ARG A 190
 None
 1.33A 4bqfA-2vmfA:
undetectable		 4bqfA-2vmfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 GLY A 398
ARG A 447
GLU A 440
ARG A 190
 None
 1.20A 4bqfA-2vmfA:
undetectable		 4bqfA-2vmfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ARG A 296
ASN A 351
GLU A 349
ILE A 353
 None
 1.09A 4d39A-2vmfA:
undetectable		 4d39A-2vmfA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A 296
ASN A 351
GLU A 349
ILE A 353
 None
 1.10A 4d39B-2vmfA:
undetectable		 4d39B-2vmfA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 784
LEU A 809
LEU A 832
ILE A 859
ARG A 626
 None
None
None
None
BR  A1894 (-4.2A)
 1.29A 4f4dA-2vmfA:
undetectable		 4f4dA-2vmfA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A 551
GLY A 528
GLU A 344
MET A 391
 None
None
EDO  A1872 ( 4.5A)
None
 1.19A 4g0vB-2vmfA:
1.9		 4g0vB-2vmfA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 660
ARG A 823
THR A 566
 None
 0.51A 4i13A-2vmfA:
undetectable		 4i13A-2vmfA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 187
ALA A 466
PHE A 476
PHE A 472
PHE A 172
 None
 1.37A 4iaqA-2vmfA:
undetectable		 4iaqA-2vmfA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 VAL A 141
LEU A 145
ILE A  96
THR A  93
 None
 0.87A 4ma7A-2vmfA:
undetectable		 4ma7A-2vmfA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A 571
GLN A 587
GLY A 592
 None
 0.49A 4odoC-2vmfA:
undetectable		 4odoC-2vmfA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A 589
ASP A 199
GLN A 646
 None
MVL  A1865 ( 2.9A)
None
 0.88A 4oltA-2vmfA:
undetectable
4oltB-2vmfA:
undetectable		 4oltA-2vmfA:
14.69
4oltB-2vmfA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 660
ARG A 823
THR A 566
 None
 0.50A 4p3rA-2vmfA:
undetectable		 4p3rA-2vmfA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLU A  90
THR A 206
HIS A  60
LEU A  63
 EDO  A1875 (-3.3A)
None
None
None
 1.15A 4pfjA-2vmfA:
undetectable		 4pfjA-2vmfA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 HIS A 511
ASP A 529
ASN A 460
GLY A 459
PHE A 508
 EDO  A1872 (-4.6A)
None
None
None
None
 1.48A 4pgfA-2vmfA:
undetectable		 4pgfA-2vmfA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLN A 646
SER A 589
ASP A 199
 None
None
MVL  A1865 ( 2.9A)
 0.90A 4qwpA-2vmfA:
undetectable
4qwpB-2vmfA:
undetectable		 4qwpA-2vmfA:
14.57
4qwpB-2vmfA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASN A  77
PHE A 570
TYR A 661
 CL  A1897 (-3.5A)
None
None
 0.81A 4u15A-2vmfA:
undetectable		 4u15A-2vmfA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 416
TYR A 406
ALA A 409
 None
 0.55A 4ybnA-2vmfA:
undetectable		 4ybnA-2vmfA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASN A 265
THR A 304
PRO A 305
THR A 306
 None
EDO  A1896 (-3.6A)
None
EDO  A1896 (-3.5A)
 1.09A 4yoaA-2vmfA:
undetectable		 4yoaA-2vmfA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 190
TYR A 400
GLU A 440
 None
 0.41A 4zzbE-2vmfA:
4.0		 4zzbE-2vmfA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DGR_A_GCSA602_1
(PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR A 537
TRP A 656
TRP A 198
ASN A 461
GLU A 555
 MVL  A1865 (-4.7A)
MVL  A1865 (-3.7A)
MVL  A1865 (-4.3A)
MVL  A1865 (-2.9A)
MVL  A1865 (-2.6A)
 1.33A 5dgrA-2vmfA:
3.2		 5dgrA-2vmfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DGR_B_GCSB602_1
(PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 11 TYR A 537
TRP A 656
TRP A 198
ASN A 461
GLU A 555
 MVL  A1865 (-4.7A)
MVL  A1865 (-3.7A)
MVL  A1865 (-4.3A)
MVL  A1865 (-2.9A)
MVL  A1865 (-2.6A)
 1.33A 5dgrB-2vmfA:
0.9		 5dgrB-2vmfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A 114
LEU A 152
TYR A 155
TRP A  89
 None
 1.17A 5hbsA-2vmfA:
undetectable		 5hbsA-2vmfA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 216
ILE A 107
PHE A 217
 None
 0.70A 5kirA-2vmfA:
undetectable		 5kirA-2vmfA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ARG A 216
MET A  34
THR A 214
LEU A  36
 None
 1.37A 5w97J-2vmfA:
undetectable		 5w97J-2vmfA:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ARG A 216
MET A  34
THR A 214
LEU A  36
 None
 1.35A 5x1bW-2vmfA:
undetectable		 5x1bW-2vmfA:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ARG A 216
MET A  34
THR A 214
LEU A  36
 None
 1.25A 5x1fW-2vmfA:
undetectable		 5x1fW-2vmfA:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A 382
GLU A 375
ARG A 823
PRO A 844
 None
 1.34A 6a4iB-2vmfA:
2.1		 6a4iB-2vmfA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASN A  71
VAL A  84
HIS A  60
 None
 0.69A 6a5yD-2vmfA:
undetectable		 6a5yD-2vmfA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 HIS A 511
ASP A 529
ASN A 460
GLY A 459
PHE A 508
 EDO  A1872 (-4.6A)
None
None
None
None
 1.36A 6exiA-2vmfA:
undetectable		 6exiA-2vmfA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 HIS A 511
ASP A 529
ASN A 460
GLY A 459
PHE A 508
 EDO  A1872 (-4.6A)
None
None
None
None
 1.38A 6exiD-2vmfA:
undetectable		 6exiD-2vmfA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ARG A 216
MET A  34
THR A 214
LEU A  36
 None
 1.39A 6nknJ-2vmfA:
undetectable		 6nknJ-2vmfA:
5.66