SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN
(Gloeobacter
violaceus) 		5 / 12 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.92A 1fm6A-2vmlA:
undetectable		 1fm6A-2vmlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN
(Gloeobacter
violaceus) 		5 / 12 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.90A 1fm6U-2vmlA:
undetectable		 1fm6U-2vmlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN
(Gloeobacter
violaceus) 		5 / 12 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.96A 1fm9A-2vmlA:
undetectable		 1fm9A-2vmlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN
(Gloeobacter
violaceus) 		5 / 12 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.96A 1k74A-2vmlA:
undetectable		 1k74A-2vmlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN
(Gloeobacter
violaceus) 		5 / 12 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.96A 1xdkE-2vmlA:
undetectable		 1xdkE-2vmlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN
(Gloeobacter
violaceus) 		5 / 12 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.85A 1xiuA-2vmlA:
undetectable		 1xiuA-2vmlA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN
(Gloeobacter
violaceus) 		5 / 12 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.85A 1xiuB-2vmlA:
undetectable		 1xiuB-2vmlA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN
(Gloeobacter
violaceus) 		5 / 12 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.87A 1xlsA-2vmlA:
undetectable		 1xlsA-2vmlA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN
(Gloeobacter
violaceus) 		5 / 12 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.88A 1xlsB-2vmlA:
undetectable		 1xlsB-2vmlA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN
(Gloeobacter
violaceus) 		5 / 12 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.88A 1xlsC-2vmlA:
undetectable		 1xlsC-2vmlA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN
(Gloeobacter
violaceus) 		5 / 12 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.88A 1xlsD-2vmlA:
undetectable		 1xlsD-2vmlA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2vml PHYCOCYANIN ALPHA
CHAIN
(Gloeobacter
violaceus) 		4 / 5 ARG A  33
THR A 148
LEU A 142
ALA A  36
 None
 1.40A 2e1qD-2vmlA:
undetectable		 2e1qD-2vmlA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 2vml PHYCOCYANIN ALPHA
CHAIN
(Gloeobacter
violaceus) 		3 / 3 GLU A   7
ASP A 106
TYR A 156
 None
 0.81A 2yvlB-2vmlA:
undetectable		 2yvlB-2vmlA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN
(Gloeobacter
violaceus) 		5 / 12 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.87A 3h0aA-2vmlA:
2.7		 3h0aA-2vmlA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN
(Gloeobacter
violaceus) 		5 / 12 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.86A 3oapA-2vmlA:
undetectable		 3oapA-2vmlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN
(Gloeobacter
violaceus) 		4 / 8 VAL B  41
LEU A  24
LEU B  38
ILE A   5
 None
CYC  B1153 (-4.1A)
CYC  B1153 (-3.8A)
None
 0.86A 3u5kD-2vmlB:
undetectable		 3u5kD-2vmlB:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN
(Gloeobacter
violaceus) 		5 / 12 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.84A 3uvvB-2vmlA:
undetectable		 3uvvB-2vmlA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2vml PHYCOCYANIN ALPHA
CHAIN
(Gloeobacter
violaceus) 		3 / 3 ALA A 130
GLN A  79
GLY A  75
 None
 0.59A 4odoC-2vmlA:
undetectable		 4odoC-2vmlA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN
(Gloeobacter
violaceus) 		4 / 8 LEU B  24
LEU B  27
VAL A  98
ILE B   9
 None
 0.91A 4oj4A-2vmlB:
undetectable		 4oj4A-2vmlB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2vml PHYCOCYANIN ALPHA
CHAIN
(Gloeobacter
violaceus) 		4 / 8 LEU A 142
VAL A 138
ALA A  41
LEU A  97
 None
 0.86A 4qrcA-2vmlA:
undetectable		 4qrcA-2vmlA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2vml PHYCOCYANIN ALPHA
CHAIN
(Gloeobacter
violaceus) 		4 / 6 SER A  11
GLY A 103
ASP A 106
GLY A 101
 None
 0.85A 5cdnC-2vmlA:
2.5
5cdnD-2vmlA:
undetectable		 5cdnC-2vmlA:
16.22
5cdnD-2vmlA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2vml PHYCOCYANIN ALPHA
CHAIN
(Gloeobacter
violaceus) 		4 / 6 SER A  11
GLY A 103
ASP A 106
GLY A 101
 None
 0.84A 5cdnT-2vmlA:
undetectable
5cdnU-2vmlA:
undetectable		 5cdnT-2vmlA:
16.22
5cdnU-2vmlA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 2vml PHYCOCYANIN ALPHA
CHAIN
(Gloeobacter
violaceus) 		4 / 6 SER A  11
GLY A 103
ASP A 106
GLY A 101
 None
 0.94A 5cdpA-2vmlA:
undetectable
5cdpB-2vmlA:
undetectable		 5cdpA-2vmlA:
16.56
5cdpB-2vmlA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 2vml PHYCOCYANIN ALPHA
CHAIN
(Gloeobacter
violaceus) 		4 / 7 ILE A 134
THR A  94
ILE A  93
LEU A  51
 None
 0.82A 5fukA-2vmlA:
undetectable
5fukB-2vmlA:
undetectable		 5fukA-2vmlA:
21.01
5fukB-2vmlA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 2vml PHYCOCYANIN ALPHA
CHAIN
(Gloeobacter
violaceus) 		5 / 10 LEU A  51
GLY A 139
ILE A  93
LEU A 147
ALA A 150
 None
 1.03A 5l0zB-2vmlA:
undetectable		 5l0zB-2vmlA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN
(Gloeobacter
violaceus) 		5 / 12 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.83A 5uanA-2vmlA:
undetectable		 5uanA-2vmlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN
(Gloeobacter
violaceus) 		5 / 12 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.92A 5z12B-2vmlA:
undetectable		 5z12B-2vmlA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN
(Gloeobacter
violaceus) 		5 / 12 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.88A 5z12C-2vmlA:
undetectable		 5z12C-2vmlA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 2vml PHYCOCYANIN ALPHA
CHAIN
(Gloeobacter
violaceus) 		4 / 7 LEU A  19
LEU A  24
ALA A  26
ALA A  27
 None
CYC  B1153 (-4.1A)
None
None
 0.75A 6a7jA-2vmlA:
undetectable		 6a7jA-2vmlA:
21.02