SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vn8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		3 / 3 ALA A 146
VAL A 166
TRP A 144
 None
 0.88A 1bdwA-2vn8A:
undetectable
1bdwB-2vn8A:
undetectable		 1bdwA-2vn8A:
4.96
1bdwB-2vn8A:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A 248
ALA A 249
ASP A 250
ASP A 251
VAL A 208
 None
 0.80A 1fb7A-2vn8A:
undetectable		 1fb7A-2vn8A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 146
ALA A 145
LEU A 186
ALA A 345
VAL A 357
 None
 1.08A 1fbyA-2vn8A:
undetectable		 1fbyA-2vn8A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.80A 1rl8B-2vn8A:
undetectable		 1rl8B-2vn8A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A 248
ALA A 249
ASP A 250
ASP A 251
ALA A 240
 None
 1.04A 1sguB-2vn8A:
undetectable		 1sguB-2vn8A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.82A 1t3rA-2vn8A:
undetectable		 1t3rA-2vn8A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.85A 1t7iA-2vn8A:
undetectable		 1t7iA-2vn8A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.63A 1t7jA-2vn8A:
undetectable		 1t7jA-2vn8A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		6 / 12 PHE A 220
GLY A 216
GLY A 215
ILE A 192
VAL A 184
ALA A 188
 None
NDP  A 600 (-3.8A)
NDP  A 600 (-3.2A)
None
None
None
 1.43A 1v2xA-2vn8A:
2.4		 1v2xA-2vn8A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 10 PHE A 372
VAL A 375
GLY A 120
ILE A  48
LEU A  57
 None
 1.02A 1z11C-2vn8A:
undetectable		 1z11C-2vn8A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 10 PHE A 372
VAL A 375
GLY A 120
ILE A  48
LEU A  57
 None
 1.10A 1z11D-2vn8A:
undetectable		 1z11D-2vn8A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A 248
ALA A 249
ASP A 250
ASP A 251
ALA A 240
 None
 1.06A 2b7zA-2vn8A:
undetectable		 2b7zA-2vn8A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A 248
ALA A 249
ASP A 250
ASP A 251
ALA A 240
 None
 1.05A 2b7zB-2vn8A:
undetectable		 2b7zB-2vn8A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		3 / 3 LYS A 381
ASP A 239
ASP A 254
 None
 1.08A 2br4A-2vn8A:
6.4		 2br4A-2vn8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		4 / 7 ARG A 388
GLU A 242
ALA A 234
ALA A 249
 NDP  A 600 (-2.9A)
None
None
None
 1.02A 2ejfA-2vn8A:
undetectable		 2ejfA-2vn8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.81A 2idwB-2vn8A:
undetectable		 2idwB-2vn8A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.68A 2ienB-2vn8A:
undetectable		 2ienB-2vn8A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.67A 2ieoA-2vn8A:
undetectable		 2ieoA-2vn8A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		3 / 3 PRO A 376
ASN A  54
ARG A  91
 None
 1.09A 2qeuB-2vn8A:
undetectable		 2qeuB-2vn8A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		6 / 12 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
ALA A 240
 None
 1.33A 2rkfB-2vn8A:
undetectable		 2rkfB-2vn8A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.83A 2rkgA-2vn8A:
undetectable		 2rkgA-2vn8A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		4 / 7 ARG A 103
ILE A  86
LEU A 119
GLY A 120
 None
 0.79A 2tsrA-2vn8A:
undetectable		 2tsrA-2vn8A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.80A 3bvbB-2vn8A:
undetectable		 3bvbB-2vn8A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.64A 3cywA-2vn8A:
undetectable		 3cywA-2vn8A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		6 / 11 ALA A 345
GLY A 163
LEU A 350
SER A 167
VAL A 166
ALA A 145
 None
 1.47A 3dcmX-2vn8A:
2.5		 3dcmX-2vn8A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A 248
ALA A 249
ASP A 250
ASP A 251
VAL A 208
 None
 0.86A 3ekqA-2vn8A:
undetectable		 3ekqA-2vn8A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.75A 3ektA-2vn8A:
undetectable		 3ektA-2vn8A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.77A 3ektC-2vn8A:
undetectable		 3ektC-2vn8A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.78A 3ekvA-2vn8A:
undetectable		 3ekvA-2vn8A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		4 / 8 GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.60A 3el0A-2vn8A:
undetectable		 3el0A-2vn8A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.80A 3gguB-2vn8A:
undetectable		 3gguB-2vn8A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.70A 3jvyA-2vn8A:
undetectable		 3jvyA-2vn8A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.77A 3jw2B-2vn8A:
undetectable		 3jw2B-2vn8A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.67A 3lzuB-2vn8A:
undetectable		 3lzuB-2vn8A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.79A 3oxwA-2vn8A:
undetectable		 3oxwA-2vn8A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.79A 3oxwC-2vn8A:
undetectable		 3oxwC-2vn8A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.84A 3oy4B-2vn8A:
undetectable		 3oy4B-2vn8A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		4 / 8 GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.68A 3so9A-2vn8A:
undetectable		 3so9A-2vn8A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		4 / 7 GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.63A 3t3cA-2vn8A:
undetectable		 3t3cA-2vn8A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.78A 3u7sA-2vn8A:
undetectable		 3u7sA-2vn8A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		4 / 7 PRO A 148
MET A 344
GLY A 347
PRO A 348
 None
 0.90A 3ucbB-2vn8A:
undetectable		 3ucbB-2vn8A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.80A 4dqbB-2vn8A:
undetectable		 4dqbB-2vn8A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.76A 4dqcB-2vn8A:
undetectable		 4dqcB-2vn8A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.78A 4dqeB-2vn8A:
undetectable		 4dqeB-2vn8A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.82A 4dqfB-2vn8A:
undetectable		 4dqfB-2vn8A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.80A 4dqhB-2vn8A:
undetectable		 4dqhB-2vn8A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		4 / 8 PHE A 220
VAL A 224
ILE A 192
ALA A 341
 None
 0.97A 4eyzA-2vn8A:
undetectable		 4eyzA-2vn8A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		4 / 8 PHE A 220
VAL A 224
ILE A 192
ALA A 341
 None
 0.96A 4eyzB-2vn8A:
undetectable		 4eyzB-2vn8A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.69A 4hlaB-2vn8A:
undetectable		 4hlaB-2vn8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.72A 4jecA-2vn8A:
undetectable		 4jecA-2vn8A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.82A 4ll3B-2vn8A:
undetectable		 4ll3B-2vn8A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.82A 4njtB-2vn8A:
undetectable		 4njtB-2vn8A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.80A 4njtD-2vn8A:
undetectable		 4njtD-2vn8A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.83A 4q1wA-2vn8A:
undetectable		 4q1wA-2vn8A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.81A 4q1xA-2vn8A:
undetectable		 4q1xA-2vn8A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		4 / 5 GLU A 165
LYS A 151
HIS A  69
GLU A  73
 None
 1.30A 5a06A-2vn8A:
7.7		 5a06A-2vn8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.82A 5e5kA-2vn8A:
undetectable		 5e5kA-2vn8A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		4 / 6 TYR A  51
GLY A 112
GLU A 114
ASP A 104
 None
 1.04A 5emlA-2vn8A:
6.5		 5emlA-2vn8A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		4 / 7 GLY A 163
VAL A 127
ILE A  75
VAL A  76
 None
 0.74A 5ik1A-2vn8A:
undetectable		 5ik1A-2vn8A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		4 / 7 GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.62A 5kqyB-2vn8A:
undetectable		 5kqyB-2vn8A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		4 / 8 GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.61A 5kr1B-2vn8A:
undetectable		 5kr1B-2vn8A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A 248
ALA A 249
ASP A 250
ASP A 251
SER A 214
 None
None
None
None
NDP  A 600 (-2.7A)
 1.05A 5t2zA-2vn8A:
undetectable		 5t2zA-2vn8A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		6 / 12 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
SER A 214
 None
None
None
None
None
NDP  A 600 (-2.7A)
 1.16A 5t2zB-2vn8A:
undetectable		 5t2zB-2vn8A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		4 / 7 ARG A 388
VAL A 244
VAL A 365
GLY A 215
 NDP  A 600 (-2.9A)
None
None
NDP  A 600 (-3.2A)
 0.76A 5x80C-2vn8A:
undetectable
5x80D-2vn8A:
undetectable		 5x80C-2vn8A:
20.32
5x80D-2vn8A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 9 ASP A  87
ASN A  84
ILE A  48
SER A  92
GLY A  93
 None
 1.38A 6awpA-2vn8A:
undetectable		 6awpA-2vn8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		4 / 6 ALA A 240
SER A 237
ALA A 213
SER A 214
 None
NDP  A 600 (-3.0A)
None
NDP  A 600 (-2.7A)
 1.05A 6bocA-2vn8A:
undetectable
6bocB-2vn8A:
undetectable
6bocC-2vn8A:
undetectable
6bocD-2vn8A:
undetectable		 6bocA-2vn8A:
7.56
6bocB-2vn8A:
7.56
6bocC-2vn8A:
7.56
6bocD-2vn8A:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_0
(PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.70A 6dgxA-2vn8A:
undetectable		 6dgxA-2vn8A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 243
GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.72A 6dh0A-2vn8A:
undetectable		 6dh0A-2vn8A:
14.02