SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vns'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ONI_D_BEZD508_0 (14.5 KDA TRANSLATIONAL INHIBITOR PROTEIN)	2vns	METALLOREDUCTASE STEAP3 (Homo sapiens)	4 / 6	PHE A 187 ASN A 162 ARG A 46 GLY A 157	None	1.11A	1oniD-2vnsA: undetectable 1oniF-2vnsA: undetectable	1oniD-2vnsA: 20.55 1oniF-2vnsA: 20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1T46_A_STIA3_2 (HOMO SAPIENS V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG)	2vns	METALLOREDUCTASE STEAP3 (Homo sapiens)	4 / 7	VAL A 165 VAL A 143 TYR A 132 ARG A 46	None	1.25A	1t46A-2vnsA: undetectable	1t46A-2vnsA: 20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LP9_D_SPMD230_1 (LS-24)	2vns	METALLOREDUCTASE STEAP3 (Homo sapiens)	3 / 3	GLU A 121 GLU A 127 ASN A 129	None	0.65A	3lp9B-2vnsA: undetectable 3lp9D-2vnsA: undetectable	3lp9B-2vnsA: 22.48 3lp9D-2vnsA: 22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FWD_A_BO2A801_1 (TTC1975 PEPTIDASE)	2vns	METALLOREDUCTASE STEAP3 (Homo sapiens)	5 / 9	VAL A 112 VAL A 165 ILE A 167 GLY A 169 ALA A 174	None	1.03A	4fwdA-2vnsA: undetectable	4fwdA-2vnsA: 15.41

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ONI_D_BEZD508_0","14.5 KDA TRANSLATIONAL INHIBITOR PROTEIN","2vns","METALLOREDUCTASE STEAP3","Homo sapiens",4,"PHE A 187;ASN A 162;ARG A  46;GLY A 157","None","1.11A","1oniD-2vnsA:undetectable;1oniF-2vnsA:undetectable","1oniD-2vnsA:20.55;1oniF-2vnsA:20.55"],["1T46_A_STIA3_2","HOMO SAPIENS V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG","2vns","METALLOREDUCTASE STEAP3","Homo sapiens",4,"VAL A 165;VAL A 143;TYR A 132;ARG A  46","None","1.25A","1t46A-2vnsA:undetectable","1t46A-2vnsA:20.52"],["3LP9_D_SPMD230_1","LS-24;LS-24","2vns","METALLOREDUCTASE STEAP3","Homo sapiens",3,"GLU A 121;GLU A 127;ASN A 129","None","0.65A","3lp9B-2vnsA:undetectable;3lp9D-2vnsA:undetectable","3lp9B-2vnsA:22.48;3lp9D-2vnsA:22.48"],["4FWD_A_BO2A801_1","TTC1975 PEPTIDASE","2vns","METALLOREDUCTASE STEAP3","Homo sapiens",5,"VAL A 112;VAL A 165;ILE A 167;GLY A 169;ALA A 174","None","1.03A","4fwdA-2vnsA:undetectable","4fwdA-2vnsA:15.41"]]