SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vo1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2vo1 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 12 SER A 156
LEU A 204
GLY A 149
SER A 181
VAL A 214
 None
None
SO4  A1275 (-3.2A)
None
None
 1.21A 1fduC-2vo1A:
2.1		 1fduC-2vo1A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2vo1 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 11 LEU A 267
VAL A 262
LEU A  32
CYH A 176
ILE A  26
 None
 1.19A 2uxoB-2vo1A:
undetectable		 2uxoB-2vo1A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 2vo1 CTP SYNTHASE 1
(Homo
sapiens) 		3 / 3 PRO A 140
LEU A 130
ARG A 127
 None
 0.91A 3aqiA-2vo1A:
3.4		 3aqiA-2vo1A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2vo1 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 12 LEU A 130
ALA A 129
VAL A 125
PHE A 163
LEU A 209
 None
 1.28A 3b0wB-2vo1A:
undetectable		 3b0wB-2vo1A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 2vo1 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 11 PRO A 158
TYR A  96
ILE A  93
ILE A  39
PRO A  41
 None
 1.48A 3ganA-2vo1A:
undetectable		 3ganA-2vo1A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 2vo1 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 9 GLY A 208
GLN A 167
LEU A 204
ARG A 164
ILE A 160
 None
 1.37A 3nbqD-2vo1A:
3.2		 3nbqD-2vo1A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 2vo1 CTP SYNTHASE 1
(Homo
sapiens) 		6 / 12 GLY A  15
ILE A  18
ILE A  19
SER A 181
VAL A 180
ILE A 178
 SO4  A1273 (-3.1A)
None
None
None
None
None
 0.85A 4ax8A-2vo1A:
undetectable		 4ax8A-2vo1A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 2vo1 CTP SYNTHASE 1
(Homo
sapiens) 		6 / 12 ILE A  18
ILE A  19
SER A 181
VAL A 180
HIS A 179
ILE A 178
 None
 1.25A 4ax8A-2vo1A:
undetectable		 4ax8A-2vo1A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 2vo1 CTP SYNTHASE 1
(Homo
sapiens) 		7 / 12 GLY A  15
ILE A  18
ILE A  19
LEU A 182
SER A 181
VAL A 180
ILE A 178
 SO4  A1273 (-3.1A)
None
None
None
None
None
None
 1.22A 4azvA-2vo1A:
undetectable		 4azvA-2vo1A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2vo1 CTP SYNTHASE 1
(Homo
sapiens) 		4 / 4 GLU A 139
PRO A 132
ILE A 131
LEU A 130
 None
 1.38A 5m45D-2vo1A:
undetectable		 5m45D-2vo1A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2vo1 CTP SYNTHASE 1
(Homo
sapiens) 		4 / 4 GLU A 139
PRO A 132
ILE A 131
LEU A 130
 None
 1.32A 5m45G-2vo1A:
0.0		 5m45G-2vo1A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2vo1 CTP SYNTHASE 1
(Homo
sapiens) 		6 / 12 VAL A 236
ILE A   4
ILE A 242
LEU A 257
VAL A  23
ILE A  19
 None
 1.43A 5mueA-2vo1A:
undetectable		 5mueA-2vo1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 2vo1 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 9 ILE A  18
ALA A  20
ILE A  19
ILE A  26
LEU A 257
 None
 1.13A 5mvmA-2vo1A:
undetectable
5mvmE-2vo1A:
undetectable		 5mvmA-2vo1A:
14.61
5mvmE-2vo1A:
14.61