SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vo8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		 2vo8 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 11 SER A 994
ASN A 996
VAL A1015
ILE A1022
SER A1026
 None
 1.48A 2trtA-2vo8A:
undetectable		 2trtA-2vo8A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 2vo8 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 10 VAL A 973
ILE A1022
LEU A1046
LEU A1028
GLY A 963
 None
 1.14A 2xf3A-2vo8A:
undetectable		 2xf3A-2vo8A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2vo8 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 7 ILE A1013
TYR A 978
THR A1048
GLY A 963
 None
 1.01A 3gssB-2vo8A:
undetectable		 3gssB-2vo8A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 2vo8 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 6 ASN A 943
ASP A1025
GLY A 969
THR A 940
 None
 1.01A 4l1aB-2vo8A:
undetectable		 4l1aB-2vo8A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 2vo8 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 7 GLY A1054
ALA A1053
GLU A 972
THR A 971
 None
 0.83A 4r1zB-2vo8A:
undetectable		 4r1zB-2vo8A:
14.55