SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vob'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
3 / 3 ALA A  32
VAL A  30
TRP A  66
None
0.97A 1av2A-2vobA:
undetectable
1av2B-2vobA:
undetectable
1av2A-2vobA:
3.50
1av2B-2vobA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
3 / 3 ALA A 347
VAL A 508
TRP A 460
None
0.93A 1c4dC-2vobA:
undetectable
1c4dD-2vobA:
undetectable
1c4dC-2vobA:
3.50
1c4dD-2vobA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 HIS A 211
LEU A 206
ALA A  93
LEU A  74
None
1.01A 1hwiB-2vobA:
undetectable
1hwiB-2vobA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 HIS A 211
LEU A 206
ALA A  93
LEU A  74
None
1.01A 1hwiC-2vobA:
undetectable
1hwiC-2vobA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
3 / 3 TRP A 506
HIS A 284
MET A 288
None
1.09A 1l5qB-2vobA:
undetectable
1l5qB-2vobA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
5 / 9 ILE A 598
PHE A 272
ILE A 612
ALA A 596
GLU A 614
None
1.33A 1mrgA-2vobA:
undetectable
1mrgA-2vobA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 7 THR A 411
TYR A 410
LEU A 244
GLN A 409
None
1.07A 1qzrA-2vobA:
undetectable
1qzrA-2vobA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 7 THR A 411
TYR A 410
LEU A 244
GLN A 409
None
1.07A 1qzrB-2vobA:
undetectable
1qzrB-2vobA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
5 / 12 ILE A 515
SER A 317
ILE A 314
ARG A 315
LEU A 301
None
1.32A 1rh3A-2vobA:
undetectable
1rh3A-2vobA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 6 PRO A 527
HIS A 526
PHE A  19
SER A  42
None
1.23A 1sbrA-2vobA:
undetectable
1sbrB-2vobA:
undetectable
1sbrA-2vobA:
14.57
1sbrB-2vobA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 7 LEU A 493
ASP A 466
THR A 465
TYR A 468
None
0.84A 1v55C-2vobA:
undetectable
1v55N-2vobA:
undetectable
1v55P-2vobA:
undetectable
1v55C-2vobA:
15.17
1v55N-2vobA:
21.23
1v55P-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
3 / 3 ALA A  32
VAL A  30
TRP A  66
None
0.93A 1w5uA-2vobA:
undetectable
1w5uB-2vobA:
undetectable
1w5uA-2vobA:
3.50
1w5uB-2vobA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
5 / 11 THR A 610
ALA A 606
SER A 377
GLY A 378
ALA A 380
None
1.18A 2f162-2vobA:
undetectable
2f162-2vobA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
5 / 11 THR A 610
ALA A 606
SER A 377
GLY A 378
ALA A 380
None
1.18A 2f16N-2vobA:
undetectable
2f16N-2vobA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
3 / 3 TRP A  66
ALA A  32
VAL A  30
None
0.94A 2izqC-2vobA:
undetectable
2izqD-2vobA:
undetectable
2izqC-2vobA:
3.50
2izqD-2vobA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 LEU A 493
ASP A 466
THR A 465
TYR A 468
None
0.93A 2y69C-2vobA:
undetectable
2y69N-2vobA:
undetectable
2y69P-2vobA:
undetectable
2y69C-2vobA:
15.17
2y69N-2vobA:
21.23
2y69P-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.85A 3ablA-2vobA:
undetectable
3ablC-2vobA:
undetectable
3ablP-2vobA:
undetectable
3ablA-2vobA:
21.23
3ablC-2vobA:
15.17
3ablP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 LEU A 493
ASP A 466
THR A 465
TYR A 468
None
0.88A 3ablC-2vobA:
undetectable
3ablN-2vobA:
undetectable
3ablP-2vobA:
undetectable
3ablC-2vobA:
15.17
3ablN-2vobA:
21.23
3ablP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.88A 3abmA-2vobA:
undetectable
3abmC-2vobA:
undetectable
3abmP-2vobA:
undetectable
3abmA-2vobA:
21.23
3abmC-2vobA:
15.17
3abmP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 LEU A 493
ASP A 466
THR A 465
TYR A 468
None
0.86A 3asnC-2vobA:
undetectable
3asnN-2vobA:
undetectable
3asnP-2vobA:
undetectable
3asnC-2vobA:
15.17
3asnN-2vobA:
21.23
3asnP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.89A 3asoA-2vobA:
undetectable
3asoC-2vobA:
undetectable
3asoP-2vobA:
undetectable
3asoA-2vobA:
21.23
3asoC-2vobA:
15.17
3asoP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 LEU A 493
ASP A 466
THR A 465
TYR A 468
None
0.90A 3asoC-2vobA:
undetectable
3asoN-2vobA:
undetectable
3asoP-2vobA:
undetectable
3asoC-2vobA:
15.17
3asoN-2vobA:
21.23
3asoP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 LEU A 220
SER A 268
ALA A 627
ALA A 628
None
1.02A 3ax9B-2vobA:
undetectable
3ax9B-2vobA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
5 / 12 LEU A 220
GLY A 599
GLY A 611
SER A 351
ALA A 596
None
1.12A 3i5uB-2vobA:
2.7
3i5uB-2vobA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
5 / 12 TYR A  25
GLY A  24
SER A  34
ASP A 146
ALA A 145
None
1.20A 3id6C-2vobA:
undetectable
3id6C-2vobA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
5 / 12 THR A 610
ALA A 606
SER A 377
GLY A 378
ALA A 380
None
1.12A 3mg02-2vobA:
undetectable
3mg0V-2vobA:
undetectable
3mg02-2vobA:
16.07
3mg0V-2vobA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
5 / 11 THR A 610
ALA A 606
SER A 377
GLY A 378
ALA A 380
None
1.14A 3mg0N-2vobA:
undetectable
3mg0N-2vobA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
5 / 7 GLY A 129
ASN A 126
TYR A 149
GLY A 132
THR A 133
None
1.47A 3tajA-2vobA:
undetectable
3tajA-2vobA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 7 PHE A 331
PHE A 329
GLY A 280
THR A 610
None
0.91A 3vnsA-2vobA:
3.4
3vnsA-2vobA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.92A 3wg7A-2vobA:
undetectable
3wg7C-2vobA:
undetectable
3wg7P-2vobA:
undetectable
3wg7A-2vobA:
21.23
3wg7C-2vobA:
15.17
3wg7P-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 LEU A 493
ASP A 466
THR A 465
TYR A 468
None
0.92A 3wg7C-2vobA:
undetectable
3wg7N-2vobA:
undetectable
3wg7P-2vobA:
undetectable
3wg7C-2vobA:
15.17
3wg7N-2vobA:
21.23
3wg7P-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.88A 3x2qA-2vobA:
undetectable
3x2qC-2vobA:
undetectable
3x2qP-2vobA:
undetectable
3x2qA-2vobA:
21.23
3x2qC-2vobA:
15.17
3x2qP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 LEU A 493
ASP A 466
THR A 465
TYR A 468
None
0.91A 3x2qC-2vobA:
undetectable
3x2qN-2vobA:
undetectable
3x2qP-2vobA:
undetectable
3x2qC-2vobA:
15.17
3x2qN-2vobA:
21.23
3x2qP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 6 PHE A 586
ALA A 332
ALA A 528
PRO A 527
None
0.99A 4dtzA-2vobA:
undetectable
4dtzA-2vobA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 6 TYR A 120
LEU A 162
VAL A 142
ASP A 146
None
1.09A 4ek1A-2vobA:
undetectable
4ek1A-2vobA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
5 / 12 LEU A 274
VAL A 277
ALA A 606
PHE A 379
VAL A 128
None
1.22A 4ib4A-2vobA:
undetectable
4ib4A-2vobA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
5 / 9 ILE A 598
PHE A 272
ILE A 612
ALA A 596
GLU A 614
None
1.29A 4yp2B-2vobA:
undetectable
4yp2B-2vobA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.91A 5b1aA-2vobA:
undetectable
5b1aC-2vobA:
undetectable
5b1aP-2vobA:
undetectable
5b1aA-2vobA:
21.23
5b1aC-2vobA:
15.17
5b1aP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.87A 5b1bA-2vobA:
undetectable
5b1bC-2vobA:
undetectable
5b1bP-2vobA:
undetectable
5b1bA-2vobA:
21.23
5b1bC-2vobA:
15.17
5b1bP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.90A 5b3sA-2vobA:
undetectable
5b3sC-2vobA:
undetectable
5b3sP-2vobA:
undetectable
5b3sA-2vobA:
21.23
5b3sC-2vobA:
15.17
5b3sP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
5 / 9 ILE A 598
PHE A 272
ILE A 612
ALA A 596
GLU A 614
None
1.30A 5cf9B-2vobA:
undetectable
5cf9B-2vobA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 LEU A 493
ASP A 466
THR A 465
TYR A 468
None
0.85A 5iy5C-2vobA:
undetectable
5iy5N-2vobA:
undetectable
5iy5P-2vobA:
undetectable
5iy5C-2vobA:
15.22
5iy5N-2vobA:
21.23
5iy5P-2vobA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
5 / 12 LEU A 516
PHE A 287
ILE A 529
ALA A 332
GLY A 599
None
0.79A 5veuA-2vobA:
undetectable
5veuA-2vobA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 GLY A 426
GLN A 321
TRP A 389
ASP A 445
None
1.01A 5vlmB-2vobA:
undetectable
5vlmB-2vobA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.90A 5w97A-2vobA:
undetectable
5w97C-2vobA:
undetectable
5w97c-2vobA:
undetectable
5w97A-2vobA:
21.23
5w97C-2vobA:
15.17
5w97c-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 7 LEU A 493
ASP A 466
THR A 465
TYR A 468
None
0.93A 5w97C-2vobA:
undetectable
5w97a-2vobA:
undetectable
5w97c-2vobA:
undetectable
5w97C-2vobA:
15.17
5w97a-2vobA:
21.23
5w97c-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.88A 5wauA-2vobA:
undetectable
5wauC-2vobA:
undetectable
5wauc-2vobA:
undetectable
5wauA-2vobA:
21.23
5wauC-2vobA:
15.17
5wauc-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 7 LEU A 493
ASP A 466
THR A 465
TYR A 468
None
0.85A 5wauC-2vobA:
undetectable
5waua-2vobA:
undetectable
5wauc-2vobA:
undetectable
5wauC-2vobA:
15.17
5waua-2vobA:
21.23
5wauc-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 4 ASP A 447
SER A 446
ASP A 445
HIS A 399
None
0.90A 5wyqB-2vobA:
0.0
5wyqB-2vobA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.91A 5x19A-2vobA:
undetectable
5x19C-2vobA:
undetectable
5x19P-2vobA:
undetectable
5x19A-2vobA:
21.23
5x19C-2vobA:
15.17
5x19P-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 7 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.88A 5x1bA-2vobA:
undetectable
5x1bC-2vobA:
undetectable
5x1bP-2vobA:
undetectable
5x1bA-2vobA:
21.23
5x1bC-2vobA:
15.17
5x1bP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 7 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.87A 5x1fA-2vobA:
undetectable
5x1fC-2vobA:
undetectable
5x1fP-2vobA:
undetectable
5x1fA-2vobA:
21.23
5x1fC-2vobA:
15.17
5x1fP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.89A 5xdqA-2vobA:
undetectable
5xdqC-2vobA:
undetectable
5xdqP-2vobA:
undetectable
5xdqA-2vobA:
21.23
5xdqC-2vobA:
15.17
5xdqP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 LEU A 493
ASP A 466
THR A 465
TYR A 468
None
0.87A 5xdqC-2vobA:
undetectable
5xdqN-2vobA:
undetectable
5xdqP-2vobA:
undetectable
5xdqC-2vobA:
15.17
5xdqN-2vobA:
21.23
5xdqP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 LEU A 493
ASP A 466
THR A 465
TYR A 468
None
0.87A 5xdxC-2vobA:
undetectable
5xdxN-2vobA:
undetectable
5xdxP-2vobA:
undetectable
5xdxC-2vobA:
14.87
5xdxN-2vobA:
21.23
5xdxP-2vobA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.92A 5z84A-2vobA:
undetectable
5z84C-2vobA:
undetectable
5z84P-2vobA:
undetectable
5z84A-2vobA:
21.23
5z84C-2vobA:
15.17
5z84P-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 7 LEU A 493
ASP A 466
THR A 465
TYR A 468
None
0.90A 5z84C-2vobA:
undetectable
5z84N-2vobA:
undetectable
5z84P-2vobA:
undetectable
5z84C-2vobA:
15.17
5z84N-2vobA:
21.23
5z84P-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.93A 5z85A-2vobA:
undetectable
5z85C-2vobA:
undetectable
5z85P-2vobA:
undetectable
5z85A-2vobA:
21.23
5z85C-2vobA:
15.17
5z85P-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 7 LEU A 493
ASP A 466
THR A 465
TYR A 468
None
0.89A 5z85C-2vobA:
undetectable
5z85N-2vobA:
undetectable
5z85P-2vobA:
undetectable
5z85C-2vobA:
15.17
5z85N-2vobA:
21.23
5z85P-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.90A 5z86A-2vobA:
undetectable
5z86C-2vobA:
undetectable
5z86P-2vobA:
undetectable
5z86A-2vobA:
21.23
5z86C-2vobA:
15.17
5z86P-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 LEU A 493
ASP A 466
THR A 465
TYR A 468
None
0.91A 5z86C-2vobA:
undetectable
5z86N-2vobA:
undetectable
5z86P-2vobA:
undetectable
5z86C-2vobA:
15.17
5z86N-2vobA:
21.23
5z86P-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.92A 5zcoA-2vobA:
undetectable
5zcoC-2vobA:
undetectable
5zcoP-2vobA:
undetectable
5zcoA-2vobA:
21.23
5zcoC-2vobA:
15.17
5zcoP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 LEU A 493
ASP A 466
THR A 465
TYR A 468
None
0.90A 5zcoC-2vobA:
undetectable
5zcoN-2vobA:
undetectable
5zcoP-2vobA:
undetectable
5zcoC-2vobA:
15.17
5zcoN-2vobA:
21.23
5zcoP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.96A 5zcpA-2vobA:
undetectable
5zcpC-2vobA:
undetectable
5zcpP-2vobA:
undetectable
5zcpA-2vobA:
21.23
5zcpC-2vobA:
15.17
5zcpP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 LEU A 493
ASP A 466
THR A 465
TYR A 468
None
0.94A 5zcpC-2vobA:
undetectable
5zcpN-2vobA:
undetectable
5zcpP-2vobA:
undetectable
5zcpC-2vobA:
15.17
5zcpN-2vobA:
21.23
5zcpP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.91A 5zcqA-2vobA:
undetectable
5zcqC-2vobA:
undetectable
5zcqP-2vobA:
undetectable
5zcqA-2vobA:
21.23
5zcqC-2vobA:
15.17
5zcqP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 8 LEU A 493
ASP A 466
THR A 465
TYR A 468
None
0.91A 6nknC-2vobA:
undetectable
6nknN-2vobA:
undetectable
6nknP-2vobA:
undetectable
6nknC-2vobA:
15.17
6nknN-2vobA:
21.23
6nknP-2vobA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major)
4 / 7 ASP A 466
THR A 465
TYR A 468
LEU A 493
None
0.92A 6nmfA-2vobA:
undetectable
6nmfC-2vobA:
undetectable
6nmfP-2vobA:
undetectable
6nmfA-2vobA:
21.23
6nmfC-2vobA:
15.17
6nmfP-2vobA:
15.17