SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vof'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 2vof BCL-2-RELATED
PROTEIN A1
(Mus
musculus) 		5 / 12 ILE A  84
GLY A  87
ALA A  41
VAL A  40
PHE A  95
 None
 1.29A 2yvlC-2vofA:
undetectable		 2yvlC-2vofA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2vof BCL-2-RELATED
PROTEIN A1
(Mus
musculus) 		4 / 8 PHE A  93
GLU A  14
SER A 119
VAL A 122
 None
 1.35A 3jx1A-2vofA:
1.3
3jx1B-2vofA:
undetectable		 3jx1A-2vofA:
16.59
3jx1B-2vofA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2vof BCL-2-RELATED
PROTEIN A1
(Mus
musculus) 		4 / 8 PHE A  93
GLU A  14
SER A 119
VAL A 122
 None
 1.37A 3nlyA-2vofA:
undetectable
3nlyB-2vofA:
1.8		 3nlyA-2vofA:
16.59
3nlyB-2vofA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2vof BCL-2-RELATED
PROTEIN A1
(Mus
musculus) 		4 / 8 PHE A  93
GLU A  14
SER A 119
VAL A 122
 None
 1.35A 3rqlA-2vofA:
1.2
3rqlB-2vofA:
undetectable		 3rqlA-2vofA:
16.59
3rqlB-2vofA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2vof BCL-2-RELATED
PROTEIN A1
(Mus
musculus) 		4 / 8 PHE A  93
GLU A  14
SER A 119
VAL A 122
 None
 1.36A 4d32A-2vofA:
1.8
4d32B-2vofA:
1.7		 4d32A-2vofA:
16.59
4d32B-2vofA:
16.59