SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vos'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
4 / 6 LEU A 308
VAL A 328
VAL A 287
GLN A 280
None
1.09A 1e7aB-2vosA:
undetectable
1e7aB-2vosA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
4 / 8 LEU A 381
ASN A 408
LEU A 414
LEU A 419
None
0.96A 1e7cA-2vosA:
3.5
1e7cA-2vosA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 11 SER A 251
LEU A 248
LEU A 306
MET A 244
VAL A 258
None
1.40A 1ee2A-2vosA:
4.0
1ee2A-2vosA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 11 SER A 251
LEU A 248
LEU A 306
MET A 244
VAL A 258
None
1.39A 1ee2B-2vosA:
2.6
1ee2B-2vosA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
4 / 6 HIS A  70
ILE A  71
ALA A 309
VAL A  80
None
0.91A 1hk1A-2vosA:
3.5
1hk1A-2vosA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 9 GLY A  73
VAL A  80
GLY A 237
ILE A 236
ILE A  71
None
0.98A 1hpvA-2vosA:
undetectable
1hpvA-2vosA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 11 PHE A 154
SER A 152
ILE A 129
ALA A 159
ALA A 185
None
1.44A 1jb0B-2vosA:
undetectable
1jb0B-2vosA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
3 / 3 ALA A 301
HIS A 302
VAL A 305
None
0.34A 1lqtB-2vosA:
4.0
1lqtB-2vosA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
3 / 3 ALA A 301
HIS A 302
VAL A 305
None
0.30A 1lquB-2vosA:
3.6
1lquB-2vosA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
4 / 8 GLY A 180
GLU A 217
ASN A 187
ILE A 221
None
0.85A 2dtjA-2vosA:
undetectable
2dtjB-2vosA:
undetectable
2dtjA-2vosA:
17.73
2dtjB-2vosA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
3 / 3 ALA A 363
GLY A  76
SER A 200
ADP  A1490 (-3.5A)
ADP  A1490 (-3.1A)
None
0.55A 2ivuA-2vosA:
undetectable
2ivuA-2vosA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
4 / 5 SER A 473
VAL A 383
SER A 410
VAL A 475
None
1.15A 2j9cA-2vosA:
undetectable
2j9cB-2vosA:
undetectable
2j9cC-2vosA:
undetectable
2j9cA-2vosA:
13.50
2j9cB-2vosA:
13.50
2j9cC-2vosA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 LEU A 132
LEU A 135
GLN A 139
ALA A 159
MET A 151
None
1.17A 2oz7A-2vosA:
undetectable
2oz7A-2vosA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
3 / 3 ARG A  64
GLU A 155
SER A  65
None
0.79A 2xkkA-2vosA:
undetectable
2xkkC-2vosA:
undetectable
2xkkA-2vosA:
21.72
2xkkC-2vosA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 11 SER A 310
GLN A 277
LEU A 293
LEU A 279
ASN A 303
None
None
None
None
ADP  A1490 (-3.2A)
1.11A 2xn5A-2vosA:
undetectable
2xn5A-2vosA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 ILE A 470
GLY A 472
SER A 473
ALA A 477
VAL A 389
None
1.04A 2yvlA-2vosA:
3.3
2yvlA-2vosA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 ILE A 470
GLY A 472
SER A 473
ALA A 477
VAL A 389
None
1.03A 2yvlC-2vosA:
3.1
2yvlC-2vosA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 9 ALA A 259
VAL A 235
GLY A 237
LEU A 284
ALA A 309
None
0.95A 2z0yB-2vosA:
2.7
2z0yB-2vosA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
3 / 3 ARG A  82
VAL A  88
THR A  95
GOL  A1497 (-4.5A)
None
None
0.58A 3cyxA-2vosA:
undetectable
3cyxA-2vosA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 THR A  98
ALA A  72
ALA A  81
VAL A  84
THR A 232
None
1.15A 3czhA-2vosA:
undetectable
3czhA-2vosA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 VAL A 193
ALA A 191
ALA A 254
VAL A  84
ILE A  71
None
1.04A 3czhA-2vosA:
undetectable
3czhA-2vosA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 GLN A 322
GLY A 325
GLY A 286
PHE A 265
LEU A 284
None
1.09A 3kkzB-2vosA:
undetectable
3kkzB-2vosA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 9 GLY A 472
ALA A 355
GLY A 339
ILE A 352
LEU A 364
None
ADP  A1490 (-3.7A)
None
None
None
0.79A 3ogpA-2vosA:
undetectable
3ogpA-2vosA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 ASP A 210
GLY A 213
ALA A 215
ALA A 219
LEU A 247
None
1.15A 3p5nA-2vosA:
undetectable
3p5nA-2vosA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 ASP A 210
GLY A 213
ALA A 215
ALA A 219
LEU A 247
None
1.15A 3p5nB-2vosA:
undetectable
3p5nB-2vosA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 11 PHE A 154
SER A 152
ILE A 129
ALA A 159
ALA A 185
None
1.44A 3pcqB-2vosA:
undetectable
3pcqB-2vosA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
4 / 8 VAL A 389
ASP A 390
LEU A 393
LEU A 421
None
0.78A 3roxA-2vosA:
undetectable
3roxA-2vosA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
6 / 12 LEU A 247
ALA A  72
VAL A  80
GLY A  76
ILE A 236
ILE A 196
None
None
None
ADP  A1490 (-3.1A)
None
None
1.47A 3s54B-2vosA:
undetectable
3s54B-2vosA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 GLY A 181
ILE A 236
GLY A  73
ALA A  72
ALA A 194
None
1.07A 3sudB-2vosA:
undetectable
3sudB-2vosA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 LEU A 103
VAL A 475
GLY A 478
ALA A 479
LEU A 483
None
0.98A 4coxA-2vosA:
undetectable
4coxA-2vosA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 LEU A 103
VAL A 475
GLY A 478
ALA A 479
LEU A 483
None
0.99A 4coxB-2vosA:
undetectable
4coxB-2vosA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 LEU A 103
VAL A 475
GLY A 478
ALA A 479
LEU A 483
None
0.99A 4coxD-2vosA:
undetectable
4coxD-2vosA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
4 / 7 LEU A  49
PRO A 149
SER A 140
MET A 151
None
1.15A 4klrA-2vosA:
2.5
4klrA-2vosA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 11 GLY A 478
GLY A 339
LEU A 103
GLU A 108
GLN A 489
None
1.03A 4l8fB-2vosA:
3.5
4l8fB-2vosA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
3 / 3 HIS A 302
VAL A 335
LEU A 293
None
GOL  A1497 (-3.8A)
None
0.70A 4m2vA-2vosA:
undetectable
4m2vA-2vosA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 LEU A 103
VAL A 475
GLY A 478
ALA A 479
LEU A 483
None
0.91A 4otyA-2vosA:
undetectable
4otyA-2vosA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 LEU A 103
VAL A 475
GLY A 478
ALA A 479
LEU A 483
None
0.92A 4otyB-2vosA:
undetectable
4otyB-2vosA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 LEU A 103
VAL A 475
GLY A 478
ALA A 479
LEU A 483
None
0.95A 4rrwC-2vosA:
undetectable
4rrwC-2vosA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 LEU A 103
VAL A 475
GLY A 478
ALA A 479
LEU A 483
None
0.97A 4rrwD-2vosA:
undetectable
4rrwD-2vosA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 LEU A 103
VAL A 475
GLY A 478
ALA A 479
LEU A 483
None
0.95A 4rrzC-2vosA:
undetectable
4rrzC-2vosA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 LEU A 103
VAL A 475
GLY A 478
ALA A 479
LEU A 483
None
0.97A 4rrzD-2vosA:
undetectable
4rrzD-2vosA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
4 / 5 GLY A 424
ALA A 423
GLY A 428
PRO A 429
None
0.86A 4u9uA-2vosA:
undetectable
4u9uA-2vosA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
4 / 5 GLY A 424
ALA A 423
GLY A 428
PRO A 429
None
0.88A 4u9uB-2vosA:
undetectable
4u9uB-2vosA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 10 VAL A 133
GLU A 130
THR A 125
VAL A 156
LEU A  36
None
1.32A 4yb6C-2vosA:
undetectable
4yb6F-2vosA:
undetectable
4yb6C-2vosA:
20.65
4yb6F-2vosA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 10 LEU A  36
VAL A 133
GLU A 130
THR A 125
VAL A 156
None
1.32A 4yb6A-2vosA:
undetectable
4yb6D-2vosA:
undetectable
4yb6A-2vosA:
20.65
4yb6D-2vosA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 10 LEU A  36
VAL A 133
GLU A 130
THR A 125
VAL A 156
None
1.32A 4yb6D-2vosA:
undetectable
4yb6E-2vosA:
undetectable
4yb6D-2vosA:
20.65
4yb6E-2vosA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 10 SER A 310
GLN A 277
LEU A 293
LEU A 279
ASN A 303
None
None
None
None
ADP  A1490 (-3.2A)
1.13A 4yiaA-2vosA:
undetectable
4yiaA-2vosA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 VAL A 195
ALA A 307
SER A 310
THR A 336
ARG A 340
None
None
None
GOL  A1497 (-3.3A)
ADP  A1490 (-3.6A)
1.18A 5m54B-2vosA:
4.1
5m54B-2vosA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 VAL A 195
ALA A 307
SER A 310
THR A 336
ARG A 340
None
None
None
GOL  A1497 (-3.3A)
ADP  A1490 (-3.6A)
1.17A 5m54E-2vosA:
4.1
5m54E-2vosA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 ALA A  81
ALA A 395
ALA A 365
THR A 367
LEU A 341
None
1.26A 5tl8A-2vosA:
undetectable
5tl8A-2vosA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
4 / 8 VAL A 188
PRO A  62
GLY A  60
LEU A  59
None
0.81A 5w3jB-2vosA:
undetectable
5w3jB-2vosA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
5 / 12 ALA A 334
ALA A 359
ALA A 363
THR A 367
LEU A 341
GOL  A1497 (-4.6A)
ADP  A1490 ( 4.6A)
ADP  A1490 (-3.5A)
None
None
1.37A 6aycA-2vosA:
undetectable
6aycA-2vosA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
4 / 7 VAL A 174
ILE A 189
GLY A 216
ALA A  72
None
0.86A 6hd6B-2vosA:
undetectable
6hd6B-2vosA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis)
4 / 7 GLY A 360
HIS A 296
GLU A 342
GLY A 339
ADP  A1490 (-3.6A)
None
None
None
0.95A 6n7fA-2vosA:
2.6
6n7fA-2vosA:
10.86