SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vow'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		4 / 5 TYR A 243
TYR A 233
PRO A 234
ASP A 229
 None
 1.30A 1i7zB-2vowA:
0.5		 1i7zB-2vowA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		5 / 10 ALA A 163
VAL A 329
ILE A  98
GLY A  99
GLY A 326
 None
 1.07A 1k6cA-2vowA:
undetectable		 1k6cA-2vowA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_B_DVAB8_0
(GRAMICIDIN A)		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		4 / 5 VAL A 206
TRP A 130
TRP A 136
VAL A 204
 None
 1.24A 1micA-2vowA:
undetectable
1micB-2vowA:
undetectable		 1micA-2vowA:
3.65
1micB-2vowA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		4 / 7 TYR A  94
ILE A 331
ILE A 333
PHE A 139
 None
 0.82A 1upfB-2vowA:
undetectable		 1upfB-2vowA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		4 / 7 LEU A  96
PHE A  68
ILE A 331
PHE A  87
 None
 0.80A 2opxA-2vowA:
undetectable		 2opxA-2vowA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA6_0
(GRAMICIDIN A)		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		4 / 5 VAL A 204
TRP A 211
TRP A 130
TRP A 136
 None
 1.39A 2xdcA-2vowA:
undetectable
2xdcB-2vowA:
undetectable		 2xdcA-2vowA:
3.65
2xdcB-2vowA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB6_0
(GRAMICIDIN A)		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		4 / 5 TRP A 211
TRP A 130
TRP A 136
VAL A 204
 None
 1.38A 2xdcA-2vowA:
undetectable
2xdcB-2vowA:
undetectable		 2xdcA-2vowA:
3.65
2xdcB-2vowA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA6_0
(VAL-GRAMICIDIN A)		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		4 / 5 VAL A 204
TRP A 211
TRP A 130
TRP A 136
 None
 1.36A 2y5mA-2vowA:
undetectable
2y5mB-2vowA:
undetectable		 2y5mA-2vowA:
3.65
2y5mB-2vowA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_B_DVAB6_0
(VAL-GRAMICIDIN A)		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		4 / 5 TRP A 211
TRP A 130
TRP A 136
VAL A 204
 None
 1.37A 2y5mA-2vowA:
undetectable
2y5mB-2vowA:
undetectable		 2y5mA-2vowA:
3.65
2y5mB-2vowA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA6_0
(VAL-GRAMICIDIN A)		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		4 / 5 VAL A 204
TRP A 211
TRP A 130
TRP A 136
 None
 1.38A 2y6nA-2vowA:
undetectable
2y6nB-2vowA:
undetectable		 2y6nA-2vowA:
3.65
2y6nB-2vowA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB6_0
(VAL-GRAMICIDIN A)		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		4 / 5 TRP A 211
TRP A 130
TRP A 136
VAL A 204
 None
 1.38A 2y6nA-2vowA:
undetectable
2y6nB-2vowA:
undetectable		 2y6nA-2vowA:
3.65
2y6nB-2vowA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_B_ACTB600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		4 / 5 ARG A 153
ALA A 277
GLU A 301
HIS A 164
 None
 1.40A 3mbgB-2vowA:
undetectable
3mbgC-2vowA:
undetectable		 3mbgB-2vowA:
16.32
3mbgC-2vowA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		4 / 5 GLU A 301
HIS A 164
ARG A 153
ALA A 277
 None
 1.42A 3mbgB-2vowA:
undetectable
3mbgC-2vowA:
undetectable		 3mbgB-2vowA:
16.32
3mbgC-2vowA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_B_URFB521_1
(RNA DEPENDENT RNA
POLYMERASE)		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		4 / 4 ARG A 153
ASP A 274
ASP A 250
ASP A 252
 None
CA  A1338 (-2.7A)
CA  A1338 (-3.2A)
CA  A1338 (-3.3A)
 1.41A 3naiB-2vowA:
0.0		 3naiB-2vowA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		4 / 5 ARG A 153
ASP A 274
ASP A 250
ASP A 252
 None
CA  A1338 (-2.7A)
CA  A1338 (-3.2A)
CA  A1338 (-3.3A)
 1.44A 3naiC-2vowA:
undetectable		 3naiC-2vowA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		5 / 10 ASP A 274
PHE A 280
THR A 332
SER A 334
THR A 276
 CA  A1338 (-2.7A)
None
None
None
None
 1.38A 3um5A-2vowA:
undetectable		 3um5A-2vowA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		5 / 10 ASP A 274
PHE A 280
THR A 332
SER A 334
THR A 276
 CA  A1338 (-2.7A)
None
None
None
None
 1.37A 3um5B-2vowA:
undetectable		 3um5B-2vowA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		4 / 6 THR A 199
HIS A 132
HIS A 203
TYR A 240
 None
 1.44A 4df2A-2vowA:
undetectable		 4df2A-2vowA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		5 / 12 PHE A 280
LEU A 149
VAL A 329
ARG A  85
SER A 137
 None
 0.87A 4po0A-2vowA:
undetectable		 4po0A-2vowA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		3 / 3 TYR A 104
PRO A 106
LEU A 313
 None
 0.81A 6beoA-2vowA:
undetectable		 6beoA-2vowA:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2vow SURFACE-ASSOCIATED
PROTEIN
(Methylococcus
capsulatus) 		4 / 5 ALA A 209
TYR A 244
GLN A 207
ILE A 168
 None
 1.36A 6f6sA-2vowA:
undetectable
6f6sB-2vowA:
undetectable		 6f6sA-2vowA:
13.94
6f6sB-2vowA:
13.99