SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vp1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 9 ASP A  87
ALA A  88
GLU A  95
VAL A 326
GLY A 330
 None
 0.97A 1bcuH-2vp1A:
undetectable		 1bcuH-2vp1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 265
SER A  40
LEU A  50
LEU A  38
TYR A  51
 None
 1.30A 1fm6D-2vp1A:
undetectable		 1fm6D-2vp1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A 264
TYR A  44
LEU A  59
HIS A  43
TYR A 169
 None
FE  A1347 (-4.1A)
None
FE  A1347 (-3.3A)
FE  A1347 (-4.3A)
 1.44A 1fm6D-2vp1A:
undetectable		 1fm6D-2vp1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 TYR A 293
PHE A 294
PHE A  84
LEU A  59
VAL A  57
 None
 1.13A 1q23A-2vp1A:
undetectable
1q23B-2vp1A:
undetectable		 1q23A-2vp1A:
18.08
1q23B-2vp1A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 TYR A 293
PHE A 294
PHE A  84
LEU A  59
VAL A  57
 None
 1.13A 1q23B-2vp1A:
undetectable		 1q23B-2vp1A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 TYR A 293
PHE A 294
PHE A  84
LEU A  59
VAL A  57
 None
 1.13A 1q23C-2vp1A:
undetectable		 1q23C-2vp1A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 TYR A 293
PHE A 294
PHE A  84
LEU A  59
VAL A  57
 None
 1.16A 1q23D-2vp1A:
undetectable
1q23E-2vp1A:
undetectable		 1q23D-2vp1A:
18.08
1q23E-2vp1A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 11 TYR A 293
PHE A 294
PHE A  84
LEU A  59
VAL A  57
 None
 1.16A 1q23F-2vp1A:
undetectable		 1q23F-2vp1A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 11 TYR A 293
PHE A 294
PHE A  84
LEU A  59
VAL A  57
 None
 1.20A 1q23G-2vp1A:
undetectable		 1q23G-2vp1A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 11 TYR A 293
PHE A 294
PHE A  84
LEU A  59
VAL A  57
 None
 1.16A 1q23I-2vp1A:
undetectable		 1q23I-2vp1A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A 264
TYR A  44
LEU A  59
HIS A  43
TYR A 169
 None
FE  A1347 (-4.1A)
None
FE  A1347 (-3.3A)
FE  A1347 (-4.3A)
 1.25A 1zgyA-2vp1A:
undetectable		 1zgyA-2vp1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 GLY A  80
ASP A  81
ASN A  37
ASP A 276
 None
 1.00A 2g72B-2vp1A:
undetectable		 2g72B-2vp1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 ALA A 175
SER A 176
SER A 172
ASN A 262
 None
 1.06A 2i91A-2vp1A:
undetectable		 2i91A-2vp1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 ALA A 175
SER A 176
SER A 172
ASN A 262
 None
 1.06A 2i91B-2vp1A:
undetectable		 2i91B-2vp1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		3 / 3 ASP A 218
ASP A 144
ASP A 138
 None
 0.67A 2igtA-2vp1A:
undetectable		 2igtA-2vp1A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		3 / 3 ASP A 218
ASP A 144
ASP A 138
 None
 0.67A 2igtB-2vp1A:
undetectable		 2igtB-2vp1A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_0
(UNCHARACTERIZED
PROTEIN MJ1557)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 PHE A 281
GLY A  55
ASP A  47
ARG A  42
PHE A  84
 None
 1.06A 3a27A-2vp1A:
undetectable		 3a27A-2vp1A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 TYR A 293
PHE A 294
PHE A  84
LEU A  59
VAL A  57
 None
 1.25A 3u9fJ-2vp1A:
undetectable
3u9fK-2vp1A:
undetectable		 3u9fJ-2vp1A:
18.08
3u9fK-2vp1A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A 264
TYR A  44
LEU A  59
HIS A  43
TYR A 169
 None
FE  A1347 (-4.1A)
None
FE  A1347 (-3.3A)
FE  A1347 (-4.3A)
 1.04A 3vn2A-2vp1A:
undetectable		 3vn2A-2vp1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 8 ASP A 335
SER A 336
ARG A 338
GLY A 182
 None
 1.00A 4af0A-2vp1A:
undetectable		 4af0A-2vp1A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 LEU A 285
VAL A  57
LEU A  50
TYR A 284
 None
 1.13A 4b3qA-2vp1A:
undetectable		 4b3qA-2vp1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 11 ALA A  76
GLY A  75
GLU A  74
GLY A  98
ASN A 271
 None
 1.14A 4e47A-2vp1A:
undetectable		 4e47A-2vp1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 11 ALA A  76
GLY A  75
GLU A  74
GLY A  98
ASN A 271
 None
 1.12A 4e47C-2vp1A:
undetectable		 4e47C-2vp1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		3 / 3 TYR A  44
HIS A  43
ARG A  42
 FE  A1347 (-4.1A)
FE  A1347 (-3.3A)
None
 0.63A 4e7bC-2vp1A:
undetectable		 4e7bC-2vp1A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 11 ALA A  76
GLY A  75
GLU A  74
GLY A  98
ASN A 271
 None
 1.13A 4jdsC-2vp1A:
undetectable		 4jdsC-2vp1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A  76
GLY A  75
GLU A  74
GLY A  98
ASN A 271
 None
 1.09A 4jlgA-2vp1A:
undetectable		 4jlgA-2vp1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 6 PHE A  84
TYR A  51
LEU A  50
THR A 127
 None
 1.23A 4paeA-2vp1A:
undetectable		 4paeA-2vp1A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 11 ALA A  76
GLY A  75
GLU A  74
GLY A  98
ASN A 271
 None
 1.09A 5ayfA-2vp1A:
undetectable		 5ayfA-2vp1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		3 / 3 GLY A  98
GLN A  72
LYS A 270
 None
 0.86A 5imsB-2vp1A:
undetectable		 5imsB-2vp1A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2vp1 PERIPLASMIC
IRON-BINDING PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 8 TYR A 124
ILE A 279
VAL A 103
ILE A  82
 None
 0.96A 5mzrE-2vp1A:
undetectable		 5mzrE-2vp1A:
14.45