SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vp3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 2vp3 VP39
(Vaccinia
virus) 		5 / 12 GLU A  23
GLU A  29
LEU A  20
TYR A 237
TYR A 204
 None
 1.32A 1httB-2vp3A:
undetectable		 1httB-2vp3A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 2vp3 VP39
(Vaccinia
virus) 		3 / 3 PRO A  71
ASP A  95
ASP A 138
 SAH  A 400 (-3.7A)
SAH  A 400 (-2.6A)
SAH  A 400 (-3.7A)
 0.54A 1sqfA-2vp3A:
7.7		 1sqfA-2vp3A:
20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VPT_A_SAMA400_0
(VP39)		 2vp3 VP39
(Vaccinia
virus) 		5 / 12 GLN A  39
ILE A  94
PRO A  71
GLY A  72
HIS A  74
 SAH  A 400 (-3.1A)
None
SAH  A 400 (-3.7A)
SAH  A 400 (-3.5A)
SAH  A 400 (-3.9A)
 0.77A 1vptA-2vp3A:
48.5		 1vptA-2vp3A:
99.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VPT_A_SAMA400_0
(VP39)		 2vp3 VP39
(Vaccinia
virus) 		11 / 12 GLN A  39
LEU A  42
TYR A  66
ILE A  67
GLY A  68
PRO A  71
GLY A  72
HIS A  74
VAL A 116
VAL A 139
LEU A 159
 SAH  A 400 (-3.1A)
SAH  A 400 (-4.7A)
SAH  A 400 (-4.6A)
None
SAH  A 400 (-3.4A)
SAH  A 400 (-3.7A)
SAH  A 400 (-3.5A)
SAH  A 400 (-3.9A)
SAH  A 400 (-3.5A)
SAH  A 400 (-4.0A)
None
 0.19A 1vptA-2vp3A:
48.5		 1vptA-2vp3A:
99.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VPT_A_SAMA400_1
(VP39)		 2vp3 VP39
(Vaccinia
virus) 		3 / 3 ASP A  95
ARG A  97
ASP A 138
 SAH  A 400 (-2.6A)
SAH  A 400 (-3.9A)
SAH  A 400 (-3.7A)
 0.39A 1vptA-2vp3A:
48.5		 1vptA-2vp3A:
99.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2vp3 VP39
(Vaccinia
virus) 		5 / 12 GLY A  68
ALA A  70
GLY A  72
VAL A 116
LYS A 175
 SAH  A 400 (-3.4A)
SAH  A 400 (-4.2A)
SAH  A 400 (-3.5A)
SAH  A 400 (-3.5A)
None
 0.78A 2nyuA-2vp3A:
9.7		 2nyuA-2vp3A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2vp3 VP39
(Vaccinia
virus) 		5 / 12 GLY A  68
ALA A  70
GLY A  72
VAL A 116
LYS A 175
 SAH  A 400 (-3.4A)
SAH  A 400 (-4.2A)
SAH  A 400 (-3.5A)
SAH  A 400 (-3.5A)
None
 0.73A 2nyuB-2vp3A:
10.0		 2nyuB-2vp3A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2vp3 VP39
(Vaccinia
virus) 		4 / 5 HIS A 262
PRO A 199
TYR A 258
TYR A 260
 None
 1.25A 2ombA-2vp3A:
undetectable
2ombB-2vp3A:
undetectable		 2ombA-2vp3A:
19.76
2ombB-2vp3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2vp3 VP39
(Vaccinia
virus) 		4 / 7 TYR A 260
HIS A 262
PRO A 199
TYR A 258
 None
 1.21A 2ombC-2vp3A:
undetectable
2ombD-2vp3A:
undetectable		 2ombC-2vp3A:
19.76
2ombD-2vp3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 2vp3 VP39
(Vaccinia
virus) 		5 / 12 ILE A  67
LEU A 167
ASN A 168
VAL A 116
VAL A 162
 None
None
None
SAH  A 400 (-3.5A)
None
 1.19A 2vn0A-2vp3A:
undetectable		 2vn0A-2vp3A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2vp3 VP39
(Vaccinia
virus) 		4 / 7 GLY A  96
HIS A  99
ILE A  67
VAL A 116
 SAH  A 400 ( 4.8A)
None
None
SAH  A 400 (-3.5A)
 0.79A 3fi0E-2vp3A:
undetectable		 3fi0E-2vp3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 2vp3 VP39
(Vaccinia
virus) 		5 / 12 GLY A  68
PRO A  71
GLY A  72
ASP A  95
ASP A 138
 SAH  A 400 (-3.4A)
SAH  A 400 (-3.7A)
SAH  A 400 (-3.5A)
SAH  A 400 (-2.6A)
SAH  A 400 (-3.7A)
 0.65A 4b17A-2vp3A:
9.4		 4b17A-2vp3A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 2vp3 VP39
(Vaccinia
virus) 		4 / 8 GLU A  14
HIS A 192
ASN A 194
SER A 212
 None
 0.84A 4f93B-2vp3A:
3.5		 4f93B-2vp3A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 2vp3 VP39
(Vaccinia
virus) 		3 / 3 ASP A  95
ARG A  97
ASP A 138
 SAH  A 400 (-2.6A)
SAH  A 400 (-3.9A)
SAH  A 400 (-3.7A)
 0.70A 4fp9D-2vp3A:
7.1		 4fp9D-2vp3A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2vp3 VP39
(Vaccinia
virus) 		3 / 3 ASP A  95
ARG A  97
ASP A 138
 SAH  A 400 (-2.6A)
SAH  A 400 (-3.9A)
SAH  A 400 (-3.7A)
 0.55A 4fzvA-2vp3A:
7.0		 4fzvA-2vp3A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2vp3 VP39
(Vaccinia
virus) 		3 / 3 SER A 173
ALA A 171
VAL A 170
 None
 0.62A 4o2bC-2vp3A:
2.0		 4o2bC-2vp3A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2vp3 VP39
(Vaccinia
virus) 		3 / 3 SER A 173
ALA A 171
VAL A 170
 None
 0.59A 4x1iA-2vp3A:
undetectable		 4x1iA-2vp3A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 2vp3 VP39
(Vaccinia
virus) 		5 / 12 LEU A  42
GLU A  46
LEU A  78
ILE A 102
LEU A 103
 SAH  A 400 (-4.7A)
None
None
None
None
 0.95A 5toaB-2vp3A:
undetectable		 5toaB-2vp3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 2vp3 VP39
(Vaccinia
virus) 		3 / 3 TYR A  66
ASP A  95
ASP A 138
 SAH  A 400 (-4.6A)
SAH  A 400 (-2.6A)
SAH  A 400 (-3.7A)
 0.14A 5x6yA-2vp3A:
3.1		 5x6yA-2vp3A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 2vp3 VP39
(Vaccinia
virus) 		6 / 12 LEU A  42
TYR A  66
GLY A  68
PRO A  71
HIS A  74
ASP A  95
 SAH  A 400 (-4.7A)
SAH  A 400 (-4.6A)
SAH  A 400 (-3.4A)
SAH  A 400 (-3.7A)
SAH  A 400 (-3.9A)
SAH  A 400 (-2.6A)
 0.58A 5x6yC-2vp3A:
12.5		 5x6yC-2vp3A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vp3 VP39
(Vaccinia
virus) 		4 / 8 GLU A  15
SER A  51
HIS A  81
LEU A 286
 None
 0.93A 5y2tB-2vp3A:
undetectable		 5y2tB-2vp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2vp3 VP39
(Vaccinia
virus) 		3 / 3 ASP A  95
ARG A  97
ASP A 138
 SAH  A 400 (-2.6A)
SAH  A 400 (-3.9A)
SAH  A 400 (-3.7A)
 0.79A 5zvgA-2vp3A:
8.4		 5zvgA-2vp3A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2vp3 VP39
(Vaccinia
virus) 		3 / 3 ASP A  95
ARG A  97
ASP A 138
 SAH  A 400 (-2.6A)
SAH  A 400 (-3.9A)
SAH  A 400 (-3.7A)
 0.78A 5zvgB-2vp3A:
8.3		 5zvgB-2vp3A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 2vp3 VP39
(Vaccinia
virus) 		3 / 3 LYS A 246
VAL A   4
ASP A   2
 None
 0.60A 6fgdA-2vp3A:
undetectable		 6fgdA-2vp3A:
23.36