SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vp8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 2vp8 DIHYDROPTEROATE
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 282
LEU A 239
VAL A 246
ASP A 238
ALA A 276
 None
 1.50A 1fpqA-2vp8A:
undetectable		 1fpqA-2vp8A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 2vp8 DIHYDROPTEROATE
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 249
ASP A 217
ASN A 142
THR A 168
ASP A 123
 None
 1.16A 2c49A-2vp8A:
2.4		 2c49A-2vp8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 2vp8 DIHYDROPTEROATE
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 246
VAL A 190
ASP A 238
ILE A 194
VAL A 193
 None
 1.41A 2qboA-2vp8A:
undetectable		 2qboA-2vp8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_F_MZMF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 2vp8 DIHYDROPTEROATE
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 10 ASP A 191
HIS A 235
VAL A 190
LEU A 239
ALA A 237
 None
 1.35A 4yhaF-2vp8A:
undetectable		 4yhaF-2vp8A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2vp8 DIHYDROPTEROATE
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 108
GLY A 137
ALA A 133
LEU A 104
VAL A 129
 None
 1.34A 5hw4B-2vp8A:
undetectable		 5hw4B-2vp8A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2vp8 DIHYDROPTEROATE
SYNTHASE 2
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 123
ASN A 142
ASP A 217
 None
 0.49A 5vopA-2vp8A:
17.2		 5vopA-2vp8A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2vp8 DIHYDROPTEROATE
SYNTHASE 2
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 123
ASN A 142
ASP A 217
 None
 0.53A 5vopB-2vp8A:
16.9		 5vopB-2vp8A:
23.84