SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vpi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 2vpi GMP SYNTHASE
(Homo
sapiens) 		5 / 11 LEU A 203
GLY A 199
VAL A 133
LEU A 143
LEU A 101
 None
 1.04A 1mx1B-2vpiA:
undetectable		 1mx1B-2vpiA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 2vpi GMP SYNTHASE
(Homo
sapiens) 		5 / 12 ASN A 111
VAL A 160
GLY A 186
ALA A 187
LEU A 151
 None
 1.08A 1r9oA-2vpiA:
undetectable		 1r9oA-2vpiA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2vpi GMP SYNTHASE
(Homo
sapiens) 		3 / 3 ASP A 155
TYR A 105
LYS A  86
 None
 1.22A 2othA-2vpiA:
undetectable		 2othA-2vpiA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2vpi GMP SYNTHASE
(Homo
sapiens) 		5 / 8 SER A 138
PHE A 114
GLY A 163
ILE A 177
ALA A 161
 None
 1.44A 3aodA-2vpiA:
undetectable		 3aodA-2vpiA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2vpi GMP SYNTHASE
(Homo
sapiens) 		3 / 3 GLY A 102
GLY A  76
GLY A 106
 None
 0.37A 3bogC-2vpiA:
undetectable		 3bogC-2vpiA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA612_0
(SERUM ALBUMIN)		 2vpi GMP SYNTHASE
(Homo
sapiens) 		4 / 4 SER A  75
HIS A 190
GLU A 192
PRO A 191
 None
 1.42A 5dbyA-2vpiA:
0.0		 5dbyA-2vpiA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2vpi GMP SYNTHASE
(Homo
sapiens) 		4 / 7 GLU A 192
GLY A 102
SER A  75
ALA A 187
 None
 0.98A 5e26A-2vpiA:
undetectable
5e26B-2vpiA:
undetectable		 5e26A-2vpiA:
24.72
5e26B-2vpiA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2vpi GMP SYNTHASE
(Homo
sapiens) 		4 / 7 ALA A 187
GLU A 192
SER A  75
GLY A 106
 None
 0.87A 5e26A-2vpiA:
undetectable
5e26B-2vpiA:
undetectable		 5e26A-2vpiA:
24.72
5e26B-2vpiA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2vpi GMP SYNTHASE
(Homo
sapiens) 		4 / 7 PHE A 140
ILE A 202
GLY A 176
LEU A 151
 None
 1.03A 5esmA-2vpiA:
undetectable		 5esmA-2vpiA:
16.76