SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vpj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		4 / 6 GLY A 386
GLY A 433
TYR A 434
SER A 384
 None
 0.96A 1eswA-2vpjA:
undetectable		 1eswA-2vpjA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		4 / 7 HIS A 474
TYR A 476
TYR A 540
LEU A 522
 None
 1.14A 1qzrA-2vpjA:
undetectable		 1qzrA-2vpjA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		4 / 7 HIS A 474
TYR A 476
TYR A 540
LEU A 522
 None
 1.11A 1qzrB-2vpjA:
undetectable		 1qzrB-2vpjA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		3 / 3 ALA A 492
VAL A 478
TRP A 547
 None
 0.87A 1w5uC-2vpjA:
undetectable
1w5uD-2vpjA:
undetectable		 1w5uC-2vpjA:
4.61
1w5uD-2vpjA:
4.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		3 / 3 ARG A 320
VAL A 285
GLY A 554
 None
 0.61A 2avvE-2vpjA:
undetectable		 2avvE-2vpjA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		5 / 12 LEU A 522
ILE A 525
ALA A 515
THR A 375
VAL A 562
 None
 1.10A 2fr3A-2vpjA:
undetectable		 2fr3A-2vpjA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		5 / 12 LEU A 522
ILE A 525
ALA A 515
THR A 375
VAL A 562
 None
 1.14A 2g78A-2vpjA:
undetectable		 2g78A-2vpjA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		4 / 7 TYR A 332
TYR A 399
ASP A 400
HIS A 328
 None
 1.42A 2pncA-2vpjA:
undetectable		 2pncA-2vpjA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		5 / 12 GLY A 420
GLY A 467
SER A 324
ILE A 334
GLY A 373
 None
 1.03A 3axzA-2vpjA:
undetectable		 3axzA-2vpjA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		5 / 12 LEU A 283
ALA A 323
VAL A 333
ILE A 537
THR A 555
 None
 1.06A 3czhB-2vpjA:
undetectable		 3czhB-2vpjA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		3 / 3 ALA A 492
VAL A 478
TRP A 547
 None
 0.86A 3l8lC-2vpjA:
undetectable
3l8lD-2vpjA:
undetectable		 3l8lC-2vpjA:
4.61
3l8lD-2vpjA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		3 / 3 PHE A 481
CYH A 511
HIS A 486
 None
 0.94A 3u9fF-2vpjA:
undetectable		 3u9fF-2vpjA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		3 / 3 PHE A 481
CYH A 511
HIS A 486
 None
 0.84A 3u9fG-2vpjA:
undetectable		 3u9fG-2vpjA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		3 / 3 PHE A 481
CYH A 511
HIS A 486
 None
 0.96A 3u9fL-2vpjA:
undetectable		 3u9fL-2vpjA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		3 / 3 PHE A 481
CYH A 511
HIS A 486
 None
 0.77A 3u9fS-2vpjA:
undetectable		 3u9fS-2vpjA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		5 / 10 VAL A 513
TYR A 512
GLY A 420
SER A 464
GLY A 480
 None
 1.33A 4mmcA-2vpjA:
undetectable		 4mmcA-2vpjA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		5 / 12 GLY A 433
GLY A 432
GLY A 465
ALA A 466
TYR A 337
 None
None
None
None
ACT  A1569 ( 4.9A)
 0.99A 4rtmA-2vpjA:
undetectable		 4rtmA-2vpjA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		5 / 12 GLY A 420
GLY A 467
SER A 324
ILE A 334
GLY A 373
 None
 0.99A 4yvgA-2vpjA:
undetectable		 4yvgA-2vpjA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		5 / 8 ALA A 372
VAL A 383
GLY A 370
GLY A 335
MET A 365
 None
None
ACT  A1569 ( 3.8A)
None
None
 1.27A 4zjzB-2vpjA:
undetectable		 4zjzB-2vpjA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		4 / 8 GLY A 480
TYR A 476
ALA A 469
GLY A 467
 None
 0.86A 5albL-2vpjA:
undetectable		 5albL-2vpjA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		3 / 3 TYR A 540
ALA A 492
TYR A 476
 None
 0.71A 5uunB-2vpjA:
undetectable		 5uunB-2vpjA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		4 / 6 SER A 464
ARG A 392
GLU A 417
TYR A 434
 None
None
ACT  A1569 (-3.8A)
None
 1.14A 5x7pA-2vpjA:
undetectable		 5x7pA-2vpjA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		4 / 6 SER A 464
ARG A 392
GLU A 417
TYR A 434
 None
None
ACT  A1569 (-3.8A)
None
 1.15A 5x7pB-2vpjA:
undetectable		 5x7pB-2vpjA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		4 / 6 SER A 464
ARG A 392
GLU A 417
TYR A 434
 None
None
ACT  A1569 (-3.8A)
None
 1.09A 5x7qA-2vpjA:
4.0		 5x7qA-2vpjA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		4 / 6 SER A 464
ARG A 392
GLU A 417
TYR A 434
 None
None
ACT  A1569 (-3.8A)
None
 1.13A 5x7qB-2vpjA:
3.2		 5x7qB-2vpjA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		4 / 6 SER A 464
ARG A 392
GLU A 417
TYR A 434
 None
None
ACT  A1569 (-3.8A)
None
 1.08A 5x7rA-2vpjA:
2.6		 5x7rA-2vpjA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		4 / 6 SER A 464
ARG A 392
GLU A 417
TYR A 434
 None
None
ACT  A1569 (-3.8A)
None
 1.14A 5x7rB-2vpjA:
3.8		 5x7rB-2vpjA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		3 / 3 PRO A 364
SER A 345
SER A 344
 None
ACT  A1568 (-3.6A)
None
 0.62A 6bpyA-2vpjA:
undetectable		 6bpyA-2vpjA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens) 		3 / 3 ASP A 350
ASP A 404
ASN A 366
 None
 0.85A 6gngB-2vpjA:
undetectable		 6gngB-2vpjA:
17.55