SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vpn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN
(Halomonas
elongata) 		5 / 12 ILE A 100
PHE A  94
LEU A 107
LEU A 299
PHE A 288
 None
 1.19A 1dtlA-2vpnA:
undetectable		 1dtlA-2vpnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNN_H_ESTH350_1
(MONOCLONAL
ANTI-ESTRADIOL
17E12E5
IMMUNOGLOBULIN
GAMMA-1 CHAIN
MONOCLONAL
ANTI-ESTRADIOL
17E12E5
IMMUNOGLOBULIN KAPPA
CHAIN)		 2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN
(Halomonas
elongata) 		5 / 10 PHE A  59
ASP A 233
LEU A 230
TYR A  25
TYR A   5
 None
 1.27A 1jnnH-2vpnA:
0.0
1jnnL-2vpnA:
0.0		 1jnnH-2vpnA:
20.77
1jnnL-2vpnA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN
(Halomonas
elongata) 		4 / 7 PHE A 187
GLU A 121
GLN A  15
TRP A 188
 None
4CS  A1311 ( 4.4A)
4CS  A1311 ( 4.6A)
4CS  A1311 (-3.6A)
 1.47A 1jqdA-2vpnA:
undetectable		 1jqdA-2vpnA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN
(Halomonas
elongata) 		4 / 8 GLY A 177
GLY A 173
GLY A 172
LEU A 174
 None
 0.59A 1qzzA-2vpnA:
undetectable		 1qzzA-2vpnA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN
(Halomonas
elongata) 		4 / 8 PHE A 187
GLU A 121
GLN A  15
TRP A 188
 None
4CS  A1311 ( 4.4A)
4CS  A1311 ( 4.6A)
4CS  A1311 (-3.6A)
 1.46A 2aoxA-2vpnA:
undetectable		 2aoxA-2vpnA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN
(Halomonas
elongata) 		4 / 8 PHE A 209
GLU A 121
GLN A  15
TYR A  10
 4CS  A1311 (-3.6A)
4CS  A1311 ( 4.4A)
4CS  A1311 ( 4.6A)
None
 1.50A 2aoxA-2vpnA:
undetectable		 2aoxA-2vpnA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_B_THAB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN
(Halomonas
elongata) 		4 / 7 PHE A 187
GLU A 121
GLN A  15
TRP A 188
 None
4CS  A1311 ( 4.4A)
4CS  A1311 ( 4.6A)
4CS  A1311 (-3.6A)
 1.46A 2aoxB-2vpnA:
0.4		 2aoxB-2vpnA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN
(Halomonas
elongata) 		4 / 5 ILE A 186
SER A 250
GLY A 248
HIS A 245
 None
 1.01A 2otfA-2vpnA:
undetectable		 2otfA-2vpnA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN
(Halomonas
elongata) 		4 / 7 PHE A 104
SER A  97
ILE A 100
GLY A 296
 None
 0.81A 2v0mB-2vpnA:
undetectable		 2v0mB-2vpnA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN
(Halomonas
elongata) 		4 / 7 PHE A 104
SER A  97
PHE A  77
GLY A 296
 None
 0.92A 2v0mC-2vpnA:
undetectable		 2v0mC-2vpnA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN
(Halomonas
elongata) 		5 / 7 MET A 213
PHE A  18
TYR A   5
ALA A 238
ALA A 234
 None
 1.43A 2wx2A-2vpnA:
undetectable		 2wx2A-2vpnA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN
(Halomonas
elongata) 		4 / 6 ILE A  79
ILE A 274
LEU A 300
PHE A 303
 None
 1.06A 3adsA-2vpnA:
undetectable		 3adsA-2vpnA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN
(Halomonas
elongata) 		4 / 7 ASN A  61
TYR A   5
HIS A 241
ALA A  21
 None
 1.39A 3frqB-2vpnA:
undetectable		 3frqB-2vpnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN
(Halomonas
elongata) 		5 / 12 ASP A  88
GLY A 207
LEU A 307
ILE A 274
THR A  85
 None
 1.11A 3pwwA-2vpnA:
undetectable		 3pwwA-2vpnA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN
(Halomonas
elongata) 		5 / 12 GLY A  68
GLY A  65
GLN A  62
LEU A 150
ALA A  74
 None
 1.20A 3sxjA-2vpnA:
undetectable		 3sxjA-2vpnA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN
(Halomonas
elongata) 		5 / 12 GLY A  68
GLY A  65
GLN A  62
LEU A 150
ALA A  74
 None
 1.19A 3sxjB-2vpnA:
undetectable		 3sxjB-2vpnA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN
(Halomonas
elongata) 		5 / 12 ASP A  95
VAL A  90
ILE A 100
ASN A  61
SER A  63
 None
 1.31A 4a84A-2vpnA:
undetectable		 4a84A-2vpnA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN
(Halomonas
elongata) 		3 / 3 LEU A 194
GLU A 196
SER A 198
 None
 0.52A 4ccqA-2vpnA:
undetectable		 4ccqA-2vpnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN
(Halomonas
elongata) 		5 / 12 PHE A  94
LEU A  91
ASP A  95
LYS A 117
ASP A 240
 None
 1.18A 5cg6A-2vpnA:
undetectable		 5cg6A-2vpnA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN
(Halomonas
elongata) 		4 / 5 PHE A  77
VAL A 310
PRO A 120
MET A 118
 None
 1.30A 6ekzA-2vpnA:
undetectable		 6ekzA-2vpnA:
13.27