SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vpq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		4 / 6 PRO A 128
ASP A 278
ASN A 280
ASP A 281
 None
 1.31A 1hpkA-2vpqA:
undetectable		 1hpkA-2vpqA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		4 / 7 GLU A 239
MET A 302
PHE A 410
ALA A 399
 None
 1.30A 1linA-2vpqA:
undetectable		 1linA-2vpqA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		5 / 12 ILE A 400
GLU A 240
VAL A 238
LEU A 425
ARG A 396
 None
 1.46A 1p5zB-2vpqA:
undetectable		 1p5zB-2vpqA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		3 / 3 THR A 304
GLU A 225
HIS A 333
 None
 0.80A 1xwfA-2vpqA:
undetectable		 1xwfA-2vpqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		3 / 3 THR A 304
GLU A 225
HIS A 333
 None
 0.80A 1xwfB-2vpqA:
undetectable		 1xwfB-2vpqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		3 / 3 THR A 304
GLU A 225
HIS A 333
 None
 0.81A 1xwfC-2vpqA:
2.9		 1xwfC-2vpqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		3 / 3 THR A 304
GLU A 225
HIS A 333
 None
 0.81A 1xwfD-2vpqA:
undetectable		 1xwfD-2vpqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		5 / 12 PHE A 410
ALA A 402
ILE A 419
ILE A 339
LEU A 426
 None
 1.25A 2bjfA-2vpqA:
undetectable		 2bjfA-2vpqA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		3 / 3 HIS A 333
ILE A 391
LEU A 426
 None
 0.66A 2kceA-2vpqA:
undetectable		 2kceA-2vpqA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		5 / 12 ILE A 400
GLU A 240
VAL A 238
LEU A 425
ARG A 396
 None
 1.46A 2no0B-2vpqA:
undetectable		 2no0B-2vpqA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		6 / 12 ARG A 405
LEU A 426
PHE A 337
ILE A 391
ALA A 406
SER A 408
 None
 1.37A 3n8xB-2vpqA:
undetectable		 3n8xB-2vpqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		5 / 12 ALA A 241
TYR A 323
ILE A 328
THR A 272
CYH A 228
 None
 1.01A 3rukA-2vpqA:
undetectable		 3rukA-2vpqA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		5 / 9 LEU A 441
LEU A 237
ILE A 335
ILE A 400
GLU A 239
 None
 1.19A 3tmzA-2vpqA:
undetectable		 3tmzA-2vpqA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		4 / 7 TYR A 358
VAL A 412
PHE A 410
ILE A 378
 None
 0.82A 3zjqA-2vpqA:
undetectable		 3zjqA-2vpqA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		4 / 7 TYR A 358
VAL A 412
PHE A 410
ILE A 378
 None
 0.82A 3zjqB-2vpqA:
undetectable		 3zjqB-2vpqA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		5 / 8 VAL A 213
LEU A 308
LEU A 311
ASP A 327
ILE A 328
 None
 1.39A 4lzrA-2vpqA:
undetectable		 4lzrA-2vpqA:
13.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		7 / 7 LYS A 236
ASN A 290
ARG A 292
GLN A 294
VAL A 295
GLU A 296
ARG A 338
 None
MG  A1450 ( 4.0A)
CL  A1452 (-3.0A)
None
CL  A1452 (-4.1A)
CL  A1452 ( 4.7A)
None
 0.61A 4mv7A-2vpqA:
57.6		 4mv7A-2vpqA:
52.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		5 / 12 ILE A 306
ILE A 208
LEU A 246
GLY A 255
ILE A 210
 None
 1.07A 4o1eA-2vpqA:
undetectable		 4o1eA-2vpqA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		5 / 12 ILE A 306
ILE A 208
LEU A 246
GLY A 255
ILE A 210
 None
 1.10A 4o1eB-2vpqA:
undetectable		 4o1eB-2vpqA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		6 / 12 ILE A 419
ILE A 423
GLY A 403
ILE A 391
PRO A 361
ILE A 339
 None
 1.28A 4q1xB-2vpqA:
undetectable		 4q1xB-2vpqA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		5 / 9 ALA A  29
THR A  41
ALA A  47
ILE A  16
ASP A  45
 None
 1.20A 4qvqK-2vpqA:
undetectable
4qvqL-2vpqA:
undetectable		 4qvqK-2vpqA:
16.63
4qvqL-2vpqA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		5 / 9 ALA A  29
THR A  41
ALA A  47
ILE A  16
ASP A  45
 None
 1.20A 4qvqY-2vpqA:
undetectable
4qvqZ-2vpqA:
undetectable		 4qvqY-2vpqA:
16.63
4qvqZ-2vpqA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		4 / 6 ILE A 400
PHE A 431
ILE A 335
GLU A 240
 None
 1.12A 4zzcB-2vpqA:
undetectable
4zzcC-2vpqA:
undetectable		 4zzcB-2vpqA:
22.42
4zzcC-2vpqA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		3 / 3 ASP A  35
SER A  58
TYR A  59
 None
 0.88A 5glmA-2vpqA:
undetectable		 5glmA-2vpqA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_D_RIOD600_0
(BIFUNCTIONAL AAC/APH)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		5 / 11 ASP A  22
GLU A 369
GLU A 301
VAL A  14
GLU A  11
 None
 1.42A 5iqdD-2vpqA:
0.8		 5iqdD-2vpqA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		4 / 5 GLU A 288
GLY A 163
ARG A 292
GLY A  82
 MG  A1451 (-1.9A)
ANP  A1449 (-3.9A)
CL  A1452 (-3.0A)
None
 1.12A 5kprA-2vpqA:
3.3		 5kprA-2vpqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		5 / 12 GLN A 211
GLY A 214
GLU A 268
LEU A 311
TYR A 217
 None
 1.49A 5vlmF-2vpqA:
undetectable		 5vlmF-2vpqA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 2vpq ACETYL-COA
CARBOXYLASE
(Staphylococcus
aureus) 		5 / 11 VAL A 366
GLY A 365
GLU A 393
ALA A 406
LEU A 389
 None
 1.24A 5x6yC-2vpqA:
2.3		 5x6yC-2vpqA:
19.19