SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vpt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 2vpt LIPOLYTIC ENZYME
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY A  81
GLY A  55
TYR A 214
SER A  80
HIS A  90
 None
 1.31A 1w76B-2vptA:
3.6		 1w76B-2vptA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vpt LIPOLYTIC ENZYME
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ILE A 217
ILE A  38
LEU A 209
LEU A  85
 None
 0.78A 3adxA-2vptA:
undetectable		 3adxA-2vptA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 2vpt LIPOLYTIC ENZYME
(Ruminiclostridiu
m
thermocellum) 		6 / 10 GLY A 122
VAL A 171
GLY A 136
LEU A 140
VAL A 176
ILE A 172
 None
 1.44A 3em3A-2vptA:
undetectable		 3em3A-2vptA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2vpt LIPOLYTIC ENZYME
(Ruminiclostridiu
m
thermocellum) 		4 / 8 LEU A 191
ASP A 157
ALA A 156
TYR A 224
 None
 1.10A 3rodA-2vptA:
3.1		 3rodA-2vptA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2vpt LIPOLYTIC ENZYME
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LYS A 166
GLU A 163
TRP A 161
 None
 1.28A 3v4tH-2vptA:
0.8		 3v4tH-2vptA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_A_ACHA301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2vpt LIPOLYTIC ENZYME
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 159
THR A  46
TYR A 214
ARG A  58
 None
 1.49A 3wipA-2vptA:
undetectable
3wipB-2vptA:
undetectable		 3wipA-2vptA:
21.40
3wipB-2vptA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2vpt LIPOLYTIC ENZYME
(Ruminiclostridiu
m
thermocellum) 		4 / 8 TYR A 159
THR A  46
TYR A 214
ARG A  58
 None
 1.46A 3wipB-2vptA:
undetectable
3wipC-2vptA:
undetectable		 3wipB-2vptA:
21.40
3wipC-2vptA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2vpt LIPOLYTIC ENZYME
(Ruminiclostridiu
m
thermocellum) 		4 / 8 TYR A 159
THR A  46
TYR A 214
ARG A  58
 None
 1.46A 3wipC-2vptA:
undetectable
3wipD-2vptA:
undetectable		 3wipC-2vptA:
21.40
3wipD-2vptA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2vpt LIPOLYTIC ENZYME
(Ruminiclostridiu
m
thermocellum) 		4 / 8 TYR A 159
THR A  46
TYR A 214
ARG A  58
 None
 1.44A 3wipD-2vptA:
undetectable
3wipE-2vptA:
undetectable		 3wipD-2vptA:
21.40
3wipE-2vptA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2vpt LIPOLYTIC ENZYME
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ARG A  58
TYR A 159
THR A  46
TYR A 214
 None
 1.48A 3wipA-2vptA:
undetectable
3wipE-2vptA:
undetectable		 3wipA-2vptA:
21.40
3wipE-2vptA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_F_ACHF301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2vpt LIPOLYTIC ENZYME
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 159
THR A  46
TYR A 214
ARG A  58
 None
 1.48A 3wipF-2vptA:
undetectable
3wipG-2vptA:
undetectable		 3wipF-2vptA:
21.40
3wipG-2vptA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_A_LYAA304_1
(FOLATE RECEPTOR BETA)		 2vpt LIPOLYTIC ENZYME
(Ruminiclostridiu
m
thermocellum) 		5 / 12 SER A  56
HIS A  93
GLY A  95
TRP A 108
SER A  77
 None
 1.33A 4kn2A-2vptA:
undetectable		 4kn2A-2vptA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_1
(FOLATE RECEPTOR BETA)		 2vpt LIPOLYTIC ENZYME
(Ruminiclostridiu
m
thermocellum) 		5 / 12 SER A  56
HIS A  93
GLY A  95
TRP A 108
SER A  77
 None
 1.39A 4kn2C-2vptA:
undetectable		 4kn2C-2vptA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 2vpt LIPOLYTIC ENZYME
(Ruminiclostridiu
m
thermocellum) 		4 / 7 VAL A  41
PRO A  40
GLU A  47
TYR A 214
 None
 1.03A 4lb2A-2vptA:
undetectable		 4lb2A-2vptA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2vpt LIPOLYTIC ENZYME
(Ruminiclostridiu
m
thermocellum) 		4 / 5 TYR A 158
GLY A  42
TYR A 168
GLY A 136
 None
 0.99A 5ayfA-2vptA:
undetectable		 5ayfA-2vptA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2vpt LIPOLYTIC ENZYME
(Ruminiclostridiu
m
thermocellum) 		5 / 11 GLY A  42
VAL A  41
GLU A  91
ASP A  43
ILE A 121
 None
 1.23A 5i3cC-2vptA:
undetectable		 5i3cC-2vptA:
22.62