SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vq5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2vq5 S-NORCOCLAURINE
SYNTHASE
(Thalictrum
flavum) 		4 / 5 TYR A 108
MET A 183
PRO A 179
LEU A  72
 None
HBA  A1203 (-2.9A)
None
None
 1.19A 2wekA-2vq5A:
0.0		 2wekA-2vq5A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2vq5 S-NORCOCLAURINE
SYNTHASE
(Thalictrum
flavum) 		4 / 6 TYR A 108
MET A 183
PRO A 179
LEU A  72
 None
HBA  A1203 (-2.9A)
None
None
 1.17A 2wekB-2vq5A:
undetectable		 2wekB-2vq5A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2vq5 S-NORCOCLAURINE
SYNTHASE
(Thalictrum
flavum) 		4 / 6 LYS A 111
GLY A  90
GLY A  89
ASP A  88
 None
 0.69A 5a06D-2vq5A:
undetectable		 5a06D-2vq5A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2vq5 S-NORCOCLAURINE
SYNTHASE
(Thalictrum
flavum) 		4 / 8 ILE A 143
TYR A  63
PHE A 112
LEU A  72
 None
HBA  A1203 (-4.7A)
HBA  A1203 (-4.6A)
None
 0.89A 5esfA-2vq5A:
undetectable		 5esfA-2vq5A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2vq5 S-NORCOCLAURINE
SYNTHASE
(Thalictrum
flavum) 		4 / 5 TYR A 108
MET A  97
THR A  98
LEU A  83
 None
HBA  A1203 (-3.4A)
None
None
 1.29A 5wauJ-2vq5A:
undetectable		 5wauJ-2vq5A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2vq5 S-NORCOCLAURINE
SYNTHASE
(Thalictrum
flavum) 		4 / 5 TYR A 108
MET A  97
THR A  98
LEU A  83
 None
HBA  A1203 (-3.4A)
None
None
 1.31A 5x19J-2vq5A:
undetectable		 5x19J-2vq5A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2vq5 S-NORCOCLAURINE
SYNTHASE
(Thalictrum
flavum) 		4 / 5 TYR A 108
MET A  97
THR A  98
LEU A  83
 None
HBA  A1203 (-3.4A)
None
None
 1.27A 5x1bJ-2vq5A:
undetectable		 5x1bJ-2vq5A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2vq5 S-NORCOCLAURINE
SYNTHASE
(Thalictrum
flavum) 		4 / 5 TYR A 108
MET A  97
THR A  98
LEU A  83
 None
HBA  A1203 (-3.4A)
None
None
 1.28A 5x1bW-2vq5A:
undetectable		 5x1bW-2vq5A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2vq5 S-NORCOCLAURINE
SYNTHASE
(Thalictrum
flavum) 		4 / 5 TYR A 108
MET A  97
THR A  98
LEU A  83
 None
HBA  A1203 (-3.4A)
None
None
 1.29A 5x1fW-2vq5A:
undetectable		 5x1fW-2vq5A:
14.89