SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vqd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 11 GLU A 311
ARG A 314
GLU A 301
ALA A 272
GLY A 104
 None
 1.38A 1cmaA-2vqdA:
undetectable
1cmaB-2vqdA:
undetectable		 1cmaA-2vqdA:
14.51
1cmaB-2vqdA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 THR A  28
ALA A  45
ASP A  46
MET A  40
LEU A  39
 None
 1.18A 1errA-2vqdA:
undetectable		 1errA-2vqdA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 7 GLU A 241
GLU A 336
ILE A 389
LEU A 384
 None
 1.34A 1q0yH-2vqdA:
undetectable
1q0yL-2vqdA:
0.7		 1q0yH-2vqdA:
17.82
1q0yL-2vqdA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  15
VAL A 303
MET A 302
ILE A 389
 None
 1.17A 2hyyC-2vqdA:
undetectable		 2hyyC-2vqdA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 7 PRO A 298
VAL A 299
SER A 300
GLU A 211
 None
 0.98A 2v2gA-2vqdA:
undetectable
2v2gB-2vqdA:
undetectable		 2v2gA-2vqdA:
20.60
2v2gB-2vqdA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 7 PRO A 298
VAL A 299
SER A 300
GLU A 211
 None
 0.99A 2v2gC-2vqdA:
undetectable
2v2gD-2vqdA:
undetectable		 2v2gC-2vqdA:
20.60
2v2gD-2vqdA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 8 PRO A 298
VAL A 299
SER A 300
GLU A 211
 None
 0.99A 2v32A-2vqdA:
undetectable
2v32B-2vqdA:
undetectable		 2v32A-2vqdA:
20.60
2v32B-2vqdA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 8 PRO A 298
VAL A 299
SER A 300
GLU A 211
 None
 1.01A 2v32A-2vqdA:
undetectable
2v32B-2vqdA:
undetectable		 2v32A-2vqdA:
20.60
2v32B-2vqdA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 8 VAL A 295
PRO A 298
VAL A 299
SER A 300
 None
 0.89A 2v32C-2vqdA:
undetectable
2v32D-2vqdA:
undetectable		 2v32C-2vqdA:
20.60
2v32D-2vqdA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 7 PRO A 298
VAL A 299
SER A 300
GLU A 211
 None
 0.98A 2v41E-2vqdA:
undetectable
2v41F-2vqdA:
undetectable		 2v41E-2vqdA:
20.60
2v41F-2vqdA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 7 PRO A 298
VAL A 299
SER A 300
GLU A 211
 None
 1.08A 2v41E-2vqdA:
undetectable
2v41F-2vqdA:
undetectable		 2v41E-2vqdA:
20.60
2v41F-2vqdA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		6 / 12 LEU A 225
GLY A 273
ALA A 272
VAL A 309
PRO A 298
ILE A 308
 None
 1.35A 3bvbB-2vqdA:
undetectable		 3bvbB-2vqdA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 427
HIS A 333
LEU A 440
LEU A 424
 None
 0.94A 3lm8B-2vqdA:
3.3
3lm8D-2vqdA:
3.9		 3lm8B-2vqdA:
20.73
3lm8D-2vqdA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 162
GLY A 163
VAL A 109
PRO A 105
VAL A 214
 None
 0.83A 3m6wA-2vqdA:
undetectable		 3m6wA-2vqdA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 163
ALA A 160
SER A 118
PHE A 286
GLU A 276
 None
None
None
None
MG  A1449 ( 2.7A)
 1.44A 3s8pA-2vqdA:
undetectable		 3s8pA-2vqdA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 163
ALA A 160
SER A 118
PHE A 286
GLU A 276
 None
None
None
None
MG  A1449 ( 2.7A)
 1.41A 3s8pB-2vqdA:
undetectable		 3s8pB-2vqdA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 335
GLY A 386
ILE A 339
THR A 390
 None
 0.80A 3spkB-2vqdA:
undetectable		 3spkB-2vqdA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 358
HIS A 356
ILE A 410
 None
 0.83A 3u52A-2vqdA:
undetectable
3u52C-2vqdA:
undetectable		 3u52A-2vqdA:
22.52
3u52C-2vqdA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 10 TYR A 375
ILE A 414
VAL A 354
TYR A 372
ILE A 410
 None
 1.39A 3uprC-2vqdA:
undetectable		 3uprC-2vqdA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 352
LEU A 371
TYR A 375
GLU A  38
 None
 1.17A 3w9tE-2vqdA:
undetectable		 3w9tE-2vqdA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 352
LEU A 371
TYR A 375
GLU A  38
 None
 1.17A 3w9tF-2vqdA:
undetectable		 3w9tF-2vqdA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 163
ALA A 160
SER A 118
PHE A 286
GLU A 276
 None
None
None
None
MG  A1449 ( 2.7A)
 1.38A 4bupA-2vqdA:
undetectable		 4bupA-2vqdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 163
ALA A 160
SER A 118
PHE A 286
GLU A 276
 None
None
None
None
MG  A1449 ( 2.7A)
 1.37A 4bupB-2vqdA:
undetectable		 4bupB-2vqdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN0_A_MTXA301_1
(FOLATE RECEPTOR BETA)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 284
GLN A 294
ARG A 228
GLY A 226
SER A 231
 None
 1.20A 4kn0A-2vqdA:
0.0		 4kn0A-2vqdA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 6 GLU A 296
ARG A 338
GLU A 211
GLU A 276
 None
None
None
MG  A1449 ( 2.7A)
 1.47A 4kr3A-2vqdA:
3.5		 4kr3A-2vqdA:
22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		7 / 7 LYS A 238
ASN A 290
ARG A 292
GLN A 294
VAL A 295
GLU A 296
ARG A 338
 None
MG  A1449 ( 4.3A)
None
None
None
None
None
 0.59A 4mv7A-2vqdA:
62.1		 4mv7A-2vqdA:
68.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 6 GLY A  81
ILE A  95
ILE A   7
LEU A 313
 None
 0.72A 4o8fB-2vqdA:
undetectable		 4o8fB-2vqdA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 5 HIS A 209
VAL A 210
GLU A 211
LYS A 238
 AP2  A1448 (-3.7A)
None
None
None
 1.22A 4p6vB-2vqdA:
undetectable
4p6vE-2vqdA:
undetectable		 4p6vB-2vqdA:
21.44
4p6vE-2vqdA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 413
VAL A 377
LEU A 371
ASN A 340
ASN A 417
 None
 1.20A 4pd5A-2vqdA:
undetectable		 4pd5A-2vqdA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 386
GLU A  12
GLU A 241
GLU A 336
 None
 0.80A 4rjdA-2vqdA:
undetectable
4rjdB-2vqdA:
undetectable		 4rjdA-2vqdA:
10.56
4rjdB-2vqdA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 THR A  28
ALA A  45
ASP A  46
MET A  40
LEU A  39
 None
 1.15A 4xi3A-2vqdA:
undetectable		 4xi3A-2vqdA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A  36
SER A  59
TYR A  60
 None
 0.88A 5glmA-2vqdA:
undetectable		 5glmA-2vqdA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 214
GLN A 262
CYH A 264
 None
 0.82A 5icxA-2vqdA:
undetectable
5icxE-2vqdA:
undetectable		 5icxA-2vqdA:
19.48
5icxE-2vqdA:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  95
ILE A   7
VAL A   5
LEU A   6
ILE A  66
 None
 0.96A 5mueA-2vqdA:
undetectable		 5mueA-2vqdA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 163
ALA A 160
SER A 118
PHE A 286
GLU A 276
 None
None
None
None
MG  A1449 ( 2.7A)
 1.47A 5wbvA-2vqdA:
undetectable		 5wbvA-2vqdA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 163
ALA A 160
SER A 118
PHE A 286
GLU A 276
 None
None
None
None
MG  A1449 ( 2.7A)
 1.46A 5wbvB-2vqdA:
undetectable		 5wbvB-2vqdA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 395
VAL A 435
LEU A 399
ALA A 429
LEU A 232
 None
 1.07A 5x23A-2vqdA:
undetectable		 5x23A-2vqdA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa) 		3 / 3 TYR A  60
ALA A  14
LEU A  39
 None
 0.74A 6d9kF-2vqdA:
4.3		 6d9kF-2vqdA:
21.12