SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vqx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 2vqx METALLOPROTEINASE
(Serratia
proteamaculans) 		3 / 3 ALA A 278
VAL A 331
TRP A 335
 None
 0.98A 1c4dA-2vqxA:
undetectable
1c4dB-2vqxA:
undetectable		 1c4dA-2vqxA:
3.66
1c4dB-2vqxA:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2vqx METALLOPROTEINASE
(Serratia
proteamaculans) 		4 / 5 LEU A 188
VAL A 191
LEU A 195
GLN A 198
 None
 0.88A 1fbmE-2vqxA:
undetectable		 1fbmE-2vqxA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 2vqx METALLOPROTEINASE
(Serratia
proteamaculans) 		4 / 4 ASP A 190
HIS A 162
ARG A 227
GLU A 186
 None
ZN  A1342 (-3.4A)
None
ZN  A1342 (-2.4A)
 0.94A 1lqtA-2vqxA:
undetectable		 1lqtA-2vqxA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 2vqx METALLOPROTEINASE
(Serratia
proteamaculans) 		5 / 12 ILE A 212
ASP A 158
GLY A 161
HIS A 162
HIS A 166
 None
None
None
ZN  A1342 (-3.4A)
ZN  A1342 (-3.3A)
 1.38A 2pgfA-2vqxA:
undetectable		 2pgfA-2vqxA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2vqx METALLOPROTEINASE
(Serratia
proteamaculans) 		4 / 5 ARG A 152
ALA A  89
ASP A  91
GLU A  92
 None
 1.05A 2xrzA-2vqxA:
undetectable		 2xrzA-2vqxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 2vqx METALLOPROTEINASE
(Serratia
proteamaculans) 		4 / 8 PHE A 150
GLY A 145
GLY A 213
MET A  14
 None
 0.82A 2y6rB-2vqxA:
undetectable		 2y6rB-2vqxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 2vqx METALLOPROTEINASE
(Serratia
proteamaculans) 		3 / 3 HIS A 162
PHE A 103
PHE A 104
 ZN  A1342 (-3.4A)
None
None
 0.51A 3lk0D-2vqxA:
undetectable		 3lk0D-2vqxA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2vqx METALLOPROTEINASE
(Serratia
proteamaculans) 		3 / 3 ASP A 244
ARG A 227
ALA A 235
 None
 0.74A 3mbgC-2vqxA:
undetectable		 3mbgC-2vqxA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 2vqx METALLOPROTEINASE
(Serratia
proteamaculans) 		4 / 6 HIS A 166
GLU A 186
ASP A 190
SER A 267
 ZN  A1342 (-3.3A)
ZN  A1342 (-2.4A)
None
None
 0.98A 4apjA-2vqxA:
5.9
4apjP-2vqxA:
undetectable		 4apjA-2vqxA:
19.35
4apjP-2vqxA:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2vqx METALLOPROTEINASE
(Serratia
proteamaculans) 		5 / 12 LEU A 241
ILE A  18
ILE A 221
ALA A 218
GLY A 143
 None
 0.99A 4enhA-2vqxA:
undetectable		 4enhA-2vqxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 2vqx METALLOPROTEINASE
(Serratia
proteamaculans) 		5 / 12 LEU A 217
ASN A 151
GLY A 215
LEU A 226
GLN A 131
 None
 1.47A 4p6xA-2vqxA:
undetectable		 4p6xA-2vqxA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 2vqx METALLOPROTEINASE
(Serratia
proteamaculans) 		4 / 6 HIS A 162
HIS A 166
TYR A 177
GLU A 186
 ZN  A1342 (-3.4A)
ZN  A1342 (-3.3A)
None
ZN  A1342 (-2.4A)
 0.84A 4pahA-2vqxA:
undetectable		 4pahA-2vqxA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2vqx METALLOPROTEINASE
(Serratia
proteamaculans) 		5 / 12 TYR A 236
ILE A 149
GLY A 242
LEU A 216
GLY A  22
 None
 1.12A 5i71A-2vqxA:
undetectable		 5i71A-2vqxA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2vqx METALLOPROTEINASE
(Serratia
proteamaculans) 		4 / 4 HIS A 162
HIS A 166
TYR A 177
GLU A 186
 ZN  A1342 (-3.4A)
ZN  A1342 (-3.3A)
None
ZN  A1342 (-2.4A)
 0.83A 5pahA-2vqxA:
undetectable		 5pahA-2vqxA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 2vqx METALLOPROTEINASE
(Serratia
proteamaculans) 		5 / 12 PHE A 311
ALA A 312
THR A 315
ILE A 292
ALA A 289
 None
 0.85A 5vceA-2vqxA:
undetectable		 5vceA-2vqxA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 2vqx METALLOPROTEINASE
(Serratia
proteamaculans) 		4 / 6 GLY A 261
THR A 256
GLN A 255
TYR A 253
 None
 1.19A 6ag0A-2vqxA:
undetectable		 6ag0A-2vqxA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 2vqx METALLOPROTEINASE
(Serratia
proteamaculans) 		4 / 6 GLY A 261
THR A 256
GLN A 255
TYR A 253
 None
 1.18A 6ag0C-2vqxA:
undetectable		 6ag0C-2vqxA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_A_GM4A301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2vqx METALLOPROTEINASE
(Serratia
proteamaculans) 		5 / 11 VAL A 340
ALA A 312
TRP A 335
MET A 250
ALA A 309
 None
 1.47A 6dk1A-2vqxA:
0.0		 6dk1A-2vqxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2vqx METALLOPROTEINASE
(Serratia
proteamaculans) 		4 / 6 HIS A 162
HIS A 166
TYR A 177
GLU A 186
 ZN  A1342 (-3.4A)
ZN  A1342 (-3.3A)
None
ZN  A1342 (-2.4A)
 0.82A 6pahA-2vqxA:
undetectable		 6pahA-2vqxA:
23.34