SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vr2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		3 / 3 VAL A 358
TRP A 360
TRP A 406
 None
 1.44A 1c4dA-2vr2A:
undetectable
1c4dB-2vr2A:
undetectable		 1c4dA-2vr2A:
3.33
1c4dB-2vr2A:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		4 / 5 HIS A  67
HIS A 192
HIS A 248
ASP A 326
 ZN  A1494 (-3.3A)
ZN  A1495 (-3.7A)
ZN  A1495 (-3.4A)
ZN  A1494 (-2.7A)
 0.74A 1e9yB-2vr2A:
21.6		 1e9yB-2vr2A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 6 HIS A  67
HIS A  69
HIS A 192
HIS A 248
ASP A 326
 ZN  A1494 (-3.3A)
ZN  A1494 (-3.3A)
ZN  A1495 (-3.7A)
ZN  A1495 (-3.4A)
ZN  A1494 (-2.7A)
 0.83A 1fweC-2vr2A:
22.4		 1fweC-2vr2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		4 / 7 GLU A 271
MET A 250
PHE A  74
ALA A 193
 None
 1.35A 1linA-2vr2A:
undetectable		 1linA-2vr2A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 12 GLU A 271
HIS A 248
PHE A  74
HIS A 192
TYR A 164
 None
ZN  A1495 (-3.4A)
None
ZN  A1495 (-3.7A)
None
 1.42A 1o86A-2vr2A:
undetectable		 1o86A-2vr2A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		4 / 8 ILE A 405
LEU A  52
LYS A 392
GLY A 444
 None
 1.04A 1os6A-2vr2A:
undetectable		 1os6A-2vr2A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		4 / 4 ALA A 292
VAL A 296
ALA A 293
HIS A 290
 None
 1.23A 1q23K-2vr2A:
undetectable		 1q23K-2vr2A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 10 ALA A 224
HIS A 248
HIS A 192
ALA A 229
THR A 230
 None
ZN  A1495 (-3.4A)
ZN  A1495 (-3.7A)
None
None
 1.09A 1r55A-2vr2A:
undetectable		 1r55A-2vr2A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		3 / 3 HIS A 291
HIS A 295
HIS A 283
 None
 0.63A 1rkyA-2vr2A:
undetectable		 1rkyA-2vr2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		4 / 7 GLY A 278
MET A 250
ILE A 359
VAL A 358
 None
 0.95A 1rxcD-2vr2A:
undetectable		 1rxcD-2vr2A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		3 / 3 HIS A 291
HIS A 295
HIS A 283
 None
 0.71A 1w2zD-2vr2A:
undetectable		 1w2zD-2vr2A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		3 / 3 GLY A 298
GLU A 194
ASN A 347
 None
 0.73A 1zq9A-2vr2A:
undetectable		 1zq9A-2vr2A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		3 / 3 VAL A  25
VAL A 397
ASP A 128
 None
 0.71A 2fumD-2vr2A:
undetectable		 2fumD-2vr2A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		3 / 3 SER A  92
ASP A  65
ASP A 354
 None
 0.80A 2plwA-2vr2A:
undetectable		 2plwA-2vr2A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		4 / 8 ASP A 326
GLU A 271
HIS A 248
HIS A 132
 ZN  A1494 (-2.7A)
None
ZN  A1495 (-3.4A)
None
 1.09A 2q0iA-2vr2A:
undetectable		 2q0iA-2vr2A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		4 / 6 VAL A  27
VAL A  31
ARG A  33
ARG A 394
 None
 1.21A 3bjwF-2vr2A:
undetectable		 3bjwF-2vr2A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		3 / 3 HIS A 291
HIS A 295
HIS A 283
 None
 0.73A 3hiiA-2vr2A:
undetectable		 3hiiA-2vr2A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		3 / 3 HIS A 291
HIS A 295
HIS A 283
 None
 0.72A 3hiiB-2vr2A:
undetectable		 3hiiB-2vr2A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		3 / 3 CYH A 433
PRO A 437
ASP A 354
 None
 0.95A 3hlwB-2vr2A:
undetectable		 3hlwB-2vr2A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		4 / 6 GLU A 226
THR A 307
ALA A 254
ALA A 255
 None
 1.16A 3ns1C-2vr2A:
undetectable		 3ns1C-2vr2A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 12 ASP A 280
MET A 250
ARG A 262
ILE A 258
ILE A 273
 None
 1.07A 3ohtA-2vr2A:
undetectable
3ohtB-2vr2A:
undetectable		 3ohtA-2vr2A:
22.52
3ohtB-2vr2A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		4 / 8 ILE A 405
LEU A  52
LYS A 392
GLY A 444
 None
 0.89A 3selX-2vr2A:
undetectable		 3selX-2vr2A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		4 / 6 SER A 379
LEU A  60
THR A 378
ARG A 355
 None
 1.44A 3thrB-2vr2A:
undetectable		 3thrB-2vr2A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		4 / 6 CYH A 328
THR A 329
ASN A 327
ASP A 326
 None
None
None
ZN  A1494 (-2.7A)
 1.41A 3w9tB-2vr2A:
undetectable		 3w9tB-2vr2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		4 / 5 PHE A 374
GLY A  93
THR A 440
VAL A 404
 None
 0.99A 3wrkD-2vr2A:
undetectable		 3wrkD-2vr2A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 12 SER A  92
GLY A  94
GLY A  93
ASP A  65
ASP A 354
 None
 1.06A 4b17A-2vr2A:
undetectable		 4b17A-2vr2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 10 GLY A 444
ALA A 401
ILE A 405
LEU A  52
ILE A   9
 None
 1.09A 4dt8B-2vr2A:
undetectable		 4dt8B-2vr2A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 9 ALA A  90
SER A 130
PHE A 386
LEU A 388
THR A  87
 None
 1.36A 4eilF-2vr2A:
undetectable		 4eilF-2vr2A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		4 / 5 HIS A  67
HIS A 192
HIS A 248
ASP A 326
 ZN  A1494 (-3.3A)
ZN  A1495 (-3.7A)
ZN  A1495 (-3.4A)
ZN  A1494 (-2.7A)
 0.69A 4h9mA-2vr2A:
23.6		 4h9mA-2vr2A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 11 ALA A  90
SER A 130
PHE A 386
LEU A 388
THR A  87
 None
 1.29A 4kyaA-2vr2A:
undetectable		 4kyaA-2vr2A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 12 ALA A  90
SER A 130
PHE A 386
LEU A 388
THR A  87
 None
 1.27A 4kyaB-2vr2A:
undetectable		 4kyaB-2vr2A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 12 ALA A  90
SER A 130
PHE A 386
LEU A 388
THR A  87
 None
 1.30A 4kyaD-2vr2A:
undetectable		 4kyaD-2vr2A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 12 ALA A  90
SER A 130
PHE A 386
LEU A 388
THR A  87
 None
 1.30A 4kyaF-2vr2A:
undetectable		 4kyaF-2vr2A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 12 ALA A  90
SER A 130
PHE A 386
LEU A 388
THR A  87
 None
 1.32A 4kyaH-2vr2A:
undetectable		 4kyaH-2vr2A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		4 / 7 LEU A  58
VAL A  59
PRO A  61
GLU A 371
 None
 1.03A 4lb2A-2vr2A:
undetectable		 4lb2A-2vr2A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		3 / 3 CYH A 433
PRO A 437
ASP A 354
 None
 0.93A 4pm5A-2vr2A:
undetectable		 4pm5A-2vr2A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 11 ASP A 354
GLY A 351
ASP A  65
THR A  87
GLY A  86
 None
 0.99A 4qgiA-2vr2A:
undetectable		 4qgiA-2vr2A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 6 HIS A  67
HIS A  69
HIS A 192
HIS A 248
ASP A 326
 ZN  A1494 (-3.3A)
ZN  A1494 (-3.3A)
ZN  A1495 (-3.7A)
ZN  A1495 (-3.4A)
ZN  A1494 (-2.7A)
 0.67A 4ubpC-2vr2A:
22.6		 4ubpC-2vr2A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 7 THR A 230
ALA A 255
LEU A 311
LEU A 315
ILE A 258
 None
 1.31A 4ubsA-2vr2A:
undetectable		 4ubsA-2vr2A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		4 / 5 ILE A 385
ILE A  99
TYR A 245
GLU A 271
 None
 1.16A 4zzcE-2vr2A:
undetectable		 4zzcE-2vr2A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 9 SER A 276
SER A 253
GLU A 223
ILE A 258
ALA A 261
 None
 1.23A 5entC-2vr2A:
undetectable		 5entC-2vr2A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 12 ASP A  17
TYR A 389
ALA A 382
ALA A 383
GLY A  63
 None
 1.10A 5igjA-2vr2A:
undetectable		 5igjA-2vr2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 12 GLY A  94
TYR A 448
ALA A 450
SER A 415
ILE A 414
 None
 1.07A 5igvA-2vr2A:
undetectable		 5igvA-2vr2A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 12 ALA A 113
ILE A 234
GLY A 270
HIS A  69
PHE A 161
 None
None
None
ZN  A1494 (-3.3A)
None
 1.16A 5jlcA-2vr2A:
undetectable		 5jlcA-2vr2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		3 / 3 VAL A 296
GLU A 226
GLU A 194
 None
 0.63A 5jsdB-2vr2A:
undetectable
5jsdC-2vr2A:
undetectable		 5jsdB-2vr2A:
22.24
5jsdC-2vr2A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 12 ALA A 383
ARG A 391
GLY A  62
ILE A 403
LEU A  35
 None
 1.13A 5ul4A-2vr2A:
2.2		 5ul4A-2vr2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 12 LEU A 311
VAL A 249
PRO A 272
THR A  95
GLY A  63
 None
 1.36A 5xiqD-2vr2A:
undetectable		 5xiqD-2vr2A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 10 GLY A 270
ASP A 319
THR A 322
ASN A 381
ILE A 385
 None
 0.98A 6exiA-2vr2A:
undetectable		 6exiA-2vr2A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 10 GLY A 270
ASP A 319
THR A 322
ASN A 381
ILE A 385
 None
 0.96A 6exiB-2vr2A:
undetectable		 6exiB-2vr2A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 12 GLY A 270
ASP A 319
THR A 322
ASN A 381
ILE A 385
 None
 0.97A 6exiC-2vr2A:
undetectable
6exiD-2vr2A:
undetectable		 6exiC-2vr2A:
14.76
6exiD-2vr2A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens) 		5 / 12 GLY A 270
ASP A 319
THR A 322
ASN A 381
ILE A 385
 None
 0.95A 6exiC-2vr2A:
undetectable
6exiD-2vr2A:
undetectable		 6exiC-2vr2A:
14.76
6exiD-2vr2A:
14.76