SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vr5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		6 / 12 TYR A 244
ARG A 361
ASP A 363
GLU A 399
HIS A 470
ASP A 471
 A16  A1722 (-3.6A)
A16  A1722 ( 3.6A)
A16  A1722 (-1.8A)
A16  A1722 (-4.0A)
A16  A1722 (-4.0A)
A16  A1722 (-3.4A)
 0.87A 1dedB-2vr5A:
19.5		 1dedB-2vr5A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		7 / 12 TYR A 244
HIS A 291
ARG A 361
ASP A 363
GLU A 399
HIS A 470
ASP A 471
 A16  A1722 (-3.6A)
A16  A1722 (-3.7A)
A16  A1722 ( 3.6A)
A16  A1722 (-1.8A)
A16  A1722 (-4.0A)
A16  A1722 (-4.0A)
A16  A1722 (-3.4A)
 0.62A 1mxdA-2vr5A:
17.3		 1mxdA-2vr5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6A_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 10 ILE A 563
ALA A 556
ASN A 500
LYS A 484
ASN A 553
 None
 1.28A 1n6aA-2vr5A:
0.0		 1n6aA-2vr5A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 11 ILE A 563
ALA A 556
ASN A 500
LYS A 484
ASN A 553
 None
 1.30A 1n6cA-2vr5A:
undetectable		 1n6cA-2vr5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 9 PHE A 637
GLU A 441
ASN A 444
VAL A 613
PHE A 600
 None
 1.36A 2drdA-2vr5A:
undetectable		 2drdA-2vr5A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 11 VAL A 410
PHE A 413
ILE A 397
ALA A 462
ASP A 471
 None
None
None
None
A16  A1722 (-3.4A)
 1.19A 2iyfA-2vr5A:
undetectable		 2iyfA-2vr5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 VAL A 219
LEU A 211
MET A 207
TYR A 210
PHE A 566
 None
 1.49A 2no0A-2vr5A:
undetectable		 2no0A-2vr5A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 VAL A 219
LEU A 211
MET A 207
TYR A 210
PHE A 566
 None
 1.49A 2no0B-2vr5A:
undetectable		 2no0B-2vr5A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 LEU A 211
GLY A 280
ALA A 279
VAL A 273
ILE A 208
 None
 0.80A 2o4lB-2vr5A:
undetectable		 2o4lB-2vr5A:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		3 / 3 GLY A 542
ARG A 548
TYR A 177
 None
 0.87A 2opxA-2vr5A:
undetectable		 2opxA-2vr5A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		3 / 3 GLU A 354
ASP A 346
TYR A  18
 GOL  A1724 (-4.1A)
None
None
 0.88A 2yvlB-2vr5A:
undetectable		 2yvlB-2vr5A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 VAL A 219
LEU A 211
MET A 207
TYR A 210
PHE A 566
 None
 1.46A 2ziaB-2vr5A:
undetectable		 2ziaB-2vr5A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 ARG A 361
ASP A 363
GLU A 399
ARG A 425
HIS A 470
 A16  A1722 ( 3.6A)
A16  A1722 (-1.8A)
A16  A1722 (-4.0A)
None
A16  A1722 (-4.0A)
 0.83A 3aicA-2vr5A:
undetectable		 3aicA-2vr5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 ARG A 361
ASP A 363
GLU A 399
HIS A 470
ASP A 471
 A16  A1722 ( 3.6A)
A16  A1722 (-1.8A)
A16  A1722 (-4.0A)
A16  A1722 (-4.0A)
A16  A1722 (-3.4A)
 0.79A 3aicA-2vr5A:
undetectable		 3aicA-2vr5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 ARG A 361
ASP A 363
GLU A 399
ARG A 425
HIS A 470
 A16  A1722 ( 3.6A)
A16  A1722 (-1.8A)
A16  A1722 (-4.0A)
None
A16  A1722 (-4.0A)
 0.88A 3aicB-2vr5A:
7.3		 3aicB-2vr5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 ARG A 361
ASP A 363
GLU A 399
HIS A 470
ASP A 471
 A16  A1722 ( 3.6A)
A16  A1722 (-1.8A)
A16  A1722 (-4.0A)
A16  A1722 (-4.0A)
A16  A1722 (-3.4A)
 0.80A 3aicB-2vr5A:
7.3		 3aicB-2vr5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		6 / 12 ARG A 361
ASP A 363
GLU A 399
ARG A 425
HIS A 470
TYR A 244
 A16  A1722 ( 3.6A)
A16  A1722 (-1.8A)
A16  A1722 (-4.0A)
None
A16  A1722 (-4.0A)
A16  A1722 (-3.6A)
 0.87A 3aicC-2vr5A:
7.4		 3aicC-2vr5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		6 / 12 ARG A 361
ASP A 363
GLU A 399
HIS A 470
ASP A 471
TYR A 244
 A16  A1722 ( 3.6A)
A16  A1722 (-1.8A)
A16  A1722 (-4.0A)
A16  A1722 (-4.0A)
A16  A1722 (-3.4A)
A16  A1722 (-3.6A)
 0.74A 3aicC-2vr5A:
7.4		 3aicC-2vr5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 ARG A 361
ASP A 363
GLU A 399
ARG A 425
HIS A 470
 A16  A1722 ( 3.6A)
A16  A1722 (-1.8A)
A16  A1722 (-4.0A)
None
A16  A1722 (-4.0A)
 0.89A 3aicD-2vr5A:
4.6		 3aicD-2vr5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 ARG A 361
ASP A 363
GLU A 399
HIS A 470
ASP A 471
 A16  A1722 ( 3.6A)
A16  A1722 (-1.8A)
A16  A1722 (-4.0A)
A16  A1722 (-4.0A)
A16  A1722 (-3.4A)
 0.84A 3aicD-2vr5A:
4.6		 3aicD-2vr5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 ARG A 361
ASP A 363
GLU A 399
ARG A 425
HIS A 470
 A16  A1722 ( 3.6A)
A16  A1722 (-1.8A)
A16  A1722 (-4.0A)
None
A16  A1722 (-4.0A)
 0.86A 3aicE-2vr5A:
7.6		 3aicE-2vr5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 ARG A 361
ASP A 363
GLU A 399
HIS A 470
ASP A 471
 A16  A1722 ( 3.6A)
A16  A1722 (-1.8A)
A16  A1722 (-4.0A)
A16  A1722 (-4.0A)
A16  A1722 (-3.4A)
 0.79A 3aicE-2vr5A:
7.6		 3aicE-2vr5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 ARG A 361
ASP A 363
GLU A 399
ARG A 425
HIS A 470
 A16  A1722 ( 3.6A)
A16  A1722 (-1.8A)
A16  A1722 (-4.0A)
None
A16  A1722 (-4.0A)
 0.87A 3aicF-2vr5A:
4.0		 3aicF-2vr5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 ARG A 361
ASP A 363
GLU A 399
HIS A 470
ASP A 471
 A16  A1722 ( 3.6A)
A16  A1722 (-1.8A)
A16  A1722 (-4.0A)
A16  A1722 (-4.0A)
A16  A1722 (-3.4A)
 0.81A 3aicF-2vr5A:
4.0		 3aicF-2vr5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 ARG A 361
ASP A 363
GLU A 399
HIS A 470
ASP A 471
 A16  A1722 ( 3.6A)
A16  A1722 (-1.8A)
A16  A1722 (-4.0A)
A16  A1722 (-4.0A)
A16  A1722 (-3.4A)
 0.79A 3aicG-2vr5A:
7.5		 3aicG-2vr5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 ARG A 361
ASP A 363
GLU A 399
ARG A 425
HIS A 470
 A16  A1722 ( 3.6A)
A16  A1722 (-1.8A)
A16  A1722 (-4.0A)
None
A16  A1722 (-4.0A)
 0.84A 3aicH-2vr5A:
6.8		 3aicH-2vr5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 ARG A 361
ASP A 363
GLU A 399
HIS A 470
ASP A 471
 A16  A1722 ( 3.6A)
A16  A1722 (-1.8A)
A16  A1722 (-4.0A)
A16  A1722 (-4.0A)
A16  A1722 (-3.4A)
 0.82A 3aicH-2vr5A:
6.8		 3aicH-2vr5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		3 / 3 PRO A 317
LEU A 324
ARG A 370
 None
 0.79A 3aqiB-2vr5A:
undetectable		 3aqiB-2vr5A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		4 / 7 THR A 174
THR A 537
ILE A 464
ILE A 397
 None
 0.81A 3deuA-2vr5A:
undetectable		 3deuA-2vr5A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		4 / 7 TYR A 313
THR A 292
LEU A 333
VAL A 340
 None
 1.04A 3fwfA-2vr5A:
undetectable		 3fwfA-2vr5A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		3 / 3 ILE A 307
PHE A  99
HIS A 337
 None
 0.73A 3h0aA-2vr5A:
undetectable		 3h0aA-2vr5A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 SER A  22
VAL A 146
ASP A 107
ILE A 106
ASN A 248
 None
 1.05A 3jb3A-2vr5A:
0.9		 3jb3A-2vr5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		4 / 7 TYR A  48
GLU A 144
LEU A  82
ASN A 114
 None
 1.42A 3k8mA-2vr5A:
20.2		 3k8mA-2vr5A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		4 / 7 TYR A 313
THR A 292
LEU A 333
VAL A 340
 None
 0.99A 3l63A-2vr5A:
undetectable		 3l63A-2vr5A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		4 / 7 ILE A 216
LEU A 211
LEU A 202
VAL A 224
 None
 0.88A 3r9vA-2vr5A:
undetectable
3r9vB-2vr5A:
undetectable		 3r9vA-2vr5A:
18.75
3r9vB-2vr5A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 TYR A 109
ILE A 106
ASN A 248
TYR A 312
PHE A 304
 None
 1.08A 3rzeA-2vr5A:
undetectable		 3rzeA-2vr5A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		4 / 7 TYR A 313
THR A 292
LEU A 333
VAL A 340
 None
 1.03A 3wrlE-2vr5A:
undetectable		 3wrlE-2vr5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 11 ILE A 563
ALA A 556
ASN A 500
LYS A 484
ASN A 553
 None
 1.30A 4e47A-2vr5A:
undetectable		 4e47A-2vr5A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 11 ILE A 563
ALA A 556
ASN A 500
LYS A 484
ASN A 553
 None
 1.26A 4e47B-2vr5A:
undetectable		 4e47B-2vr5A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_D_SAMD800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 10 ILE A 563
ALA A 556
ASN A 500
LYS A 484
ASN A 553
 None
 1.33A 4e47D-2vr5A:
0.0		 4e47D-2vr5A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		3 / 3 TYR A 322
HIS A 297
ARG A 321
 None
 1.20A 4e7bC-2vr5A:
undetectable		 4e7bC-2vr5A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 11 ILE A 563
ALA A 556
ASN A 500
LYS A 484
ASN A 553
 None
 1.29A 4j83A-2vr5A:
undetectable		 4j83A-2vr5A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 11 ILE A 563
ALA A 556
ASN A 500
LYS A 484
ASN A 553
 None
 1.30A 4jdsA-2vr5A:
undetectable		 4jdsA-2vr5A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 11 ILE A 563
ALA A 556
ASN A 500
LYS A 484
ASN A 553
 None
 1.30A 4jdsB-2vr5A:
undetectable		 4jdsB-2vr5A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 11 ILE A 563
ALA A 556
ASN A 500
LYS A 484
ASN A 553
 None
 1.31A 4jdsC-2vr5A:
undetectable		 4jdsC-2vr5A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_D_SAMD401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 11 ILE A 563
ALA A 556
ASN A 500
LYS A 484
ASN A 553
 None
 1.28A 4jdsD-2vr5A:
undetectable		 4jdsD-2vr5A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 ILE A 563
ALA A 556
ASN A 500
LYS A 484
ASN A 553
 None
 1.28A 4jlgA-2vr5A:
undetectable		 4jlgA-2vr5A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 11 ILE A 563
ALA A 556
ASN A 500
LYS A 484
ASN A 553
 None
 1.25A 4jlgB-2vr5A:
undetectable		 4jlgB-2vr5A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_C_ADNC403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 11 HIS A 337
SER A  34
ASP A 308
ASP A  68
ILE A  69
 None
 1.21A 4ktvC-2vr5A:
undetectable
4ktvD-2vr5A:
undetectable		 4ktvC-2vr5A:
18.68
4ktvD-2vr5A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		4 / 5 THR A 329
THR A 327
HIS A 470
ASN A 240
 A16  A1722 ( 4.4A)
None
A16  A1722 (-4.0A)
None
 1.34A 4pgfB-2vr5A:
undetectable		 4pgfB-2vr5A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 GLY A 295
ASN A 296
HIS A 297
ILE A 228
GLN A 230
 None
None
None
None
A16  A1722 (-4.4A)
 1.31A 4pooB-2vr5A:
undetectable		 4pooB-2vr5A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 9 LEU A 333
ASN A 379
VAL A 340
VAL A 344
LEU A 345
 None
 1.18A 4qd3A-2vr5A:
undetectable		 4qd3A-2vr5A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		4 / 8 ILE A 442
LEU A 532
VAL A 712
PHE A 431
 None
 0.81A 4r38A-2vr5A:
undetectable		 4r38A-2vr5A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		4 / 6 THR A 353
SER A 392
LEU A 391
ASP A 388
 None
 1.04A 4wozA-2vr5A:
3.6
4wozB-2vr5A:
3.6		 4wozA-2vr5A:
18.45
4wozB-2vr5A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		3 / 3 SER A 463
GLU A 441
GLU A 435
 None
 0.82A 4ymgB-2vr5A:
undetectable		 4ymgB-2vr5A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 11 ILE A 563
ALA A 556
ASN A 500
LYS A 484
ASN A 553
 None
 1.26A 5ayfA-2vr5A:
undetectable		 5ayfA-2vr5A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 ARG A 361
ASP A 363
GLU A 399
HIS A 470
ASP A 471
 A16  A1722 ( 3.6A)
A16  A1722 (-1.8A)
A16  A1722 (-4.0A)
A16  A1722 (-4.0A)
A16  A1722 (-3.4A)
 0.50A 5csyB-2vr5A:
6.7		 5csyB-2vr5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		4 / 7 ILE A 284
GLY A 359
PHE A 227
PHE A 249
 None
 1.13A 5hieA-2vr5A:
undetectable		 5hieA-2vr5A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 9 LEU A 446
ILE A 428
ILE A 636
PHE A 637
VAL A 613
 None
 1.45A 5igzA-2vr5A:
undetectable		 5igzA-2vr5A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		3 / 3 VAL A 179
ARG A 595
PRO A 538
 None
 0.80A 5koxA-2vr5A:
undetectable		 5koxA-2vr5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		3 / 3 ARG A 231
PHE A 227
LEU A 302
 None
 0.79A 5veuA-2vr5A:
undetectable		 5veuA-2vr5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		4 / 6 ILE A 152
ILE A 285
HIS A 226
PHE A 362
 None
 1.02A 5vkqB-2vr5A:
undetectable
5vkqC-2vr5A:
undetectable		 5vkqB-2vr5A:
17.67
5vkqC-2vr5A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		4 / 6 ILE A 152
ILE A 285
HIS A 226
PHE A 362
 None
 1.01A 5vkqC-2vr5A:
undetectable
5vkqD-2vr5A:
undetectable		 5vkqC-2vr5A:
17.67
5vkqD-2vr5A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 TYR A 244
HIS A 291
ASP A 363
HIS A 470
ASP A 471
 A16  A1722 (-3.6A)
A16  A1722 (-3.7A)
A16  A1722 (-1.8A)
A16  A1722 (-4.0A)
A16  A1722 (-3.4A)
 0.56A 6ag0A-2vr5A:
15.2		 6ag0A-2vr5A:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		4 / 7 ASP A 308
ASN A  39
ALA A  40
LEU A  97
 None
 1.10A 6ci6A-2vr5A:
undetectable		 6ci6A-2vr5A:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2vr5 GLYCOGEN OPERON
PROTEIN GLGX
(Sulfolobus
solfataricus) 		5 / 12 ASP A  68
ILE A  69
HIS A 337
SER A  34
ASP A 308
 None
 1.26A 6fbpA-2vr5A:
undetectable
6fbpB-2vr5A:
undetectable		 6fbpA-2vr5A:
7.98
6fbpB-2vr5A:
7.98