SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vra'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 2vra ROUNDABOUT 1
(Drosophila
melanogaster) 		4 / 8 VAL A 251
ARG A 209
ALA A 172
GLU A 228
 None
SO4  A1254 ( 4.8A)
None
None
 0.93A 1dmiA-2vraA:
undetectable
1dmiB-2vraA:
undetectable		 1dmiA-2vraA:
17.87
1dmiB-2vraA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2vra ROUNDABOUT 1
(Drosophila
melanogaster) 		4 / 8 TYR A 231
ASN A 230
GLU A 228
GLY A 229
 None
 0.93A 1ykiA-2vraA:
undetectable
1ykiB-2vraA:
undetectable		 1ykiA-2vraA:
22.98
1ykiB-2vraA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2vra ROUNDABOUT 1
(Drosophila
melanogaster) 		4 / 8 TYR A 231
ASN A 230
GLU A 228
GLY A 229
 None
 0.93A 1ykiA-2vraA:
undetectable
1ykiB-2vraA:
undetectable		 1ykiA-2vraA:
22.98
1ykiB-2vraA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2vra ROUNDABOUT 1
(Drosophila
melanogaster) 		4 / 8 TYR A 231
ASN A 230
GLU A 228
GLY A 229
 None
 0.90A 1ykiC-2vraA:
undetectable
1ykiD-2vraA:
undetectable		 1ykiC-2vraA:
22.98
1ykiD-2vraA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2vra ROUNDABOUT 1
(Drosophila
melanogaster) 		4 / 8 TYR A 231
ASN A 230
GLU A 228
GLY A 229
 None
 0.91A 1ykiC-2vraA:
undetectable
1ykiD-2vraA:
undetectable		 1ykiC-2vraA:
22.98
1ykiD-2vraA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2vra ROUNDABOUT 1
(Drosophila
melanogaster) 		4 / 8 ARG A 117
ASN A  70
GLN A 120
ASP A 126
 None
None
SO4  A1253 ( 3.8A)
None
 1.35A 1zzuA-2vraA:
undetectable		 1zzuA-2vraA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 2vra ROUNDABOUT 1
(Drosophila
melanogaster) 		5 / 10 ALA A 141
VAL A  79
ILE A  87
PRO A  62
ILE A  58
 None
 0.99A 3em3B-2vraA:
undetectable		 3em3B-2vraA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 2vra ROUNDABOUT 1
(Drosophila
melanogaster) 		5 / 11 ALA A 141
VAL A  79
ILE A  87
PRO A  62
ILE A  58
 None
 1.01A 3oxvD-2vraA:
undetectable		 3oxvD-2vraA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 2vra ROUNDABOUT 1
(Drosophila
melanogaster) 		5 / 10 ALA A 141
VAL A  79
ILE A  87
PRO A  62
ILE A  58
 None
 1.00A 3oxwB-2vraA:
undetectable		 3oxwB-2vraA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 2vra ROUNDABOUT 1
(Drosophila
melanogaster) 		3 / 3 ASP A 163
TRP A 189
SER A 245
 None
 0.99A 4lrhB-2vraA:
undetectable		 4lrhB-2vraA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 2vra ROUNDABOUT 1
(Drosophila
melanogaster) 		3 / 3 ASP A 163
TRP A 189
SER A 245
 None
 0.99A 4lrhF-2vraA:
undetectable		 4lrhF-2vraA:
20.76