SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vrc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		5 / 12 HIS A  87
TYR A 104
LEU A 178
HIS A 121
LEU A 117
 None
 1.29A 1fm6D-2vrcA:
undetectable		 1fm6D-2vrcA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		4 / 7 LEU A  71
THR A   6
GLY A  14
LEU A  12
 None
 0.95A 1gtiA-2vrcA:
undetectable		 1gtiA-2vrcA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		4 / 7 THR A 163
SER A 155
VAL A 221
LEU A 277
 None
 0.98A 2hdnE-2vrcA:
undetectable
2hdnF-2vrcA:
6.5
2hdnH-2vrcA:
6.5		 2hdnE-2vrcA:
9.96
2hdnF-2vrcA:
22.73
2hdnH-2vrcA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		4 / 7 SER A 155
VAL A 221
LEU A 277
THR A 163
 None
 1.01A 2hdnF-2vrcA:
6.5
2hdnG-2vrcA:
undetectable
2hdnH-2vrcA:
6.5		 2hdnF-2vrcA:
22.73
2hdnG-2vrcA:
9.96
2hdnH-2vrcA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		4 / 7 THR A 248
ALA A 154
PHE A 234
LEU A 152
 None
 1.11A 2hzqA-2vrcA:
undetectable		 2hzqA-2vrcA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		5 / 12 HIS A  87
TYR A 104
VAL A  16
HIS A 121
LEU A 117
 None
 1.29A 2prgB-2vrcA:
undetectable		 2prgB-2vrcA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		5 / 12 TYR A 104
VAL A  16
HIS A 121
LEU A 117
LEU A  83
 None
 1.26A 2prgB-2vrcA:
undetectable		 2prgB-2vrcA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		4 / 7 HIS A  19
LEU A 267
TYR A 143
ASN A 140
 None
 1.02A 3avpA-2vrcA:
undetectable		 3avpA-2vrcA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		4 / 6 THR A 174
THR A 144
LEU A 277
THR A 280
 None
 0.80A 3deuB-2vrcA:
undetectable		 3deuB-2vrcA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		5 / 12 LEU A 198
ASN A 201
GLN A 268
LEU A 270
THR A 184
 None
 1.34A 3fsuA-2vrcA:
undetectable		 3fsuA-2vrcA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		5 / 12 THR A   6
LEU A 138
THR A 136
LEU A  12
ARG A 175
 None
 1.41A 3fsuA-2vrcA:
undetectable		 3fsuA-2vrcA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_E_C2FE995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		5 / 11 THR A   6
LEU A 138
THR A 136
LEU A  12
ARG A 175
 None
 1.39A 3fsuE-2vrcA:
0.2		 3fsuE-2vrcA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		5 / 12 GLY A  75
ARG A  50
ILE A  17
GLY A  10
ALA A  31
 None
 0.97A 3sudC-2vrcA:
undetectable		 3sudC-2vrcA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		5 / 12 HIS A 121
GLY A  75
LEU A  83
ALA A   8
PHE A  72
 None
 1.25A 3vywB-2vrcA:
4.4		 3vywB-2vrcA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		4 / 6 ALA A 183
GLY A  13
LEU A  71
VAL A   5
 None
 0.92A 4dubA-2vrcA:
undetectable		 4dubA-2vrcA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		5 / 10 PHE A  64
VAL A  99
ILE A  32
ALA A   4
ALA A 103
 None
 1.10A 4j14A-2vrcA:
undetectable		 4j14A-2vrcA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		5 / 11 ALA A 179
ALA A 182
ALA A 183
THR A 187
VAL A  24
 None
 1.09A 4j6cA-2vrcA:
undetectable		 4j6cA-2vrcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		5 / 10 ALA A 179
ALA A 182
ALA A 183
THR A 187
VAL A  24
 None
 1.09A 4j6cB-2vrcA:
undetectable		 4j6cB-2vrcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		5 / 12 ALA A 179
ALA A 182
ALA A 183
THR A 187
VAL A  24
 None
 1.11A 4j6dA-2vrcA:
undetectable		 4j6dA-2vrcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		5 / 12 ALA A 179
ALA A 182
ALA A 183
THR A 187
VAL A  24
 None
 1.09A 4j6dB-2vrcA:
undetectable		 4j6dB-2vrcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		5 / 12 ALA A 179
ALA A 182
ALA A 183
THR A 187
VAL A  24
 None
 1.12A 4jbtA-2vrcA:
undetectable		 4jbtA-2vrcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		5 / 11 ALA A 179
ALA A 182
ALA A 183
THR A 187
VAL A  24
 None
 1.11A 4jbtB-2vrcA:
undetectable		 4jbtB-2vrcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		5 / 11 ILE A  73
THR A   9
GLY A  10
ARG A 175
THR A 105
 None
 1.47A 4xt7A-2vrcA:
undetectable		 4xt7A-2vrcA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		5 / 12 ILE A  84
VAL A  16
LEU A 186
ALA A 123
LEU A  12
 None
 1.14A 6a7pB-2vrcA:
undetectable		 6a7pB-2vrcA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		5 / 12 ILE A  84
VAL A  16
LEU A 186
ALA A 123
LEU A 138
 None
 1.13A 6a7pB-2vrcA:
undetectable		 6a7pB-2vrcA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		5 / 12 GLY A  75
ARG A  50
ILE A  17
GLY A  10
ALA A  31
 None
 0.85A 6c2mD-2vrcA:
undetectable		 6c2mD-2vrcA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 2vrc TRIPHENYLMETHANE
REDUCTASE
(Citrobacter
sp.
MY-5) 		5 / 12 VAL A  91
ARG A  50
ILE A  17
GLY A  10
ALA A  31
 None
 0.95A 6c2mD-2vrcA:
undetectable		 6c2mD-2vrcA:
15.24