SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vre'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		4 / 8 LEU A 152
PHE A  88
VAL A  44
LEU A  32
 None
 0.88A 1fiqC-2vreA:
undetectable		 1fiqC-2vreA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		4 / 8 ILE A 130
PHE A  67
VAL A  34
SER A  31
 None
 1.14A 1kb9A-2vreA:
undetectable
1kb9C-2vreA:
undetectable
1kb9D-2vreA:
undetectable
1kb9E-2vreA:
undetectable		 1kb9A-2vreA:
20.14
1kb9C-2vreA:
21.86
1kb9D-2vreA:
19.81
1kb9E-2vreA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		4 / 6 GLY A 147
ILE A 146
GLN A 168
VAL A 174
 None
 0.83A 1rs7B-2vreA:
undetectable		 1rs7B-2vreA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		4 / 5 ILE A 158
ILE A  70
ILE A 238
LEU A 152
 None
 0.86A 1zgyA-2vreA:
undetectable		 1zgyA-2vreA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		5 / 10 ALA A 165
ALA A 162
GLN A 163
ALA A 208
ILE A 138
 None
 1.07A 2aclC-2vreA:
undetectable		 2aclC-2vreA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		5 / 12 VAL A 189
LEU A 186
VAL A 150
GLY A 215
LEU A 234
 None
None
None
CL  A1290 ( 3.7A)
None
 1.15A 2cbrA-2vreA:
undetectable		 2cbrA-2vreA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		5 / 10 LEU A 186
ALA A 178
ASP A 179
ILE A 146
THR A 154
 None
 0.97A 3el5A-2vreA:
undetectable		 3el5A-2vreA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		5 / 9 LEU A 186
ALA A 178
ASP A 179
ILE A 146
THR A 154
 None
 0.98A 3gguB-2vreA:
undetectable		 3gguB-2vreA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		3 / 3 CYH A 161
PRO A 222
ASP A 209
 None
 0.84A 3hlwB-2vreA:
undetectable		 3hlwB-2vreA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		3 / 3 VAL A 251
VAL A 246
TRP A 271
 None
 0.90A 3l8lC-2vreA:
undetectable
3l8lD-2vreA:
undetectable		 3l8lC-2vreA:
9.76
3l8lD-2vreA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		5 / 12 LEU A 186
ALA A 178
ASP A 179
ILE A 146
THR A 154
 None
 1.06A 3spkB-2vreA:
undetectable		 3spkB-2vreA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		4 / 8 LEU A 152
PHE A  88
VAL A  44
LEU A  32
 None
 0.84A 3uniB-2vreA:
undetectable		 3uniB-2vreA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		5 / 8 VAL A  80
VAL A  79
CYH A  76
ILE A 138
ASP A 157
 None
 1.44A 3wzeA-2vreA:
undetectable		 3wzeA-2vreA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		4 / 6 GLY A 147
ILE A 146
GLN A 168
VAL A 174
 None
 0.86A 4d39B-2vreA:
undetectable		 4d39B-2vreA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		3 / 3 PHE A 127
VAL A 180
GLU A 171
 None
 0.81A 4fvqA-2vreA:
undetectable		 4fvqA-2vreA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		4 / 6 GLY A 147
ILE A 146
GLN A 168
VAL A 174
 None
 0.83A 4kcnA-2vreA:
undetectable		 4kcnA-2vreA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		3 / 3 LEU A 253
LYS A 250
THR A 249
 None
 0.61A 4lj0A-2vreA:
undetectable		 4lj0A-2vreA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		5 / 10 LEU A 186
ALA A 178
ASP A 179
ILE A 146
THR A 154
 None
 0.99A 4njtB-2vreA:
undetectable		 4njtB-2vreA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		5 / 9 LEU A 186
ALA A 178
ASP A 179
ILE A 146
THR A 154
 None
 0.97A 4njtD-2vreA:
undetectable		 4njtD-2vreA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		5 / 12 LEU A 186
ALA A 178
ASP A 179
ILE A 146
THR A 154
 None
 0.92A 4njuA-2vreA:
undetectable		 4njuA-2vreA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		5 / 12 LEU A 186
ALA A 178
ASP A 179
ILE A 146
THR A 154
 None
 0.94A 4njuC-2vreA:
undetectable		 4njuC-2vreA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		4 / 8 TYR A 160
ILE A 158
ILE A 138
ALA A 235
 None
 0.97A 4ou1A-2vreA:
undetectable		 4ou1A-2vreA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		3 / 3 CYH A 161
PRO A 222
ASP A 209
 None
 0.85A 4pm5A-2vreA:
undetectable		 4pm5A-2vreA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		4 / 8 GLU A 198
MET A 207
GLU A 210
ALA A 211
 None
 0.78A 4rjdA-2vreA:
undetectable
4rjdB-2vreA:
undetectable		 4rjdA-2vreA:
13.09
4rjdB-2vreA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		5 / 11 PHE A 166
GLY A 147
GLY A 149
GLU A 171
ILE A  92
 None
 1.43A 4zvmA-2vreA:
undetectable
4zvmB-2vreA:
undetectable		 4zvmA-2vreA:
21.24
4zvmB-2vreA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		5 / 6 SER A  31
GLU A  30
GLY A 149
ASP A 151
GLY A  91
 None
 1.13A 5cdnA-2vreA:
undetectable
5cdnB-2vreA:
undetectable		 5cdnA-2vreA:
21.95
5cdnB-2vreA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		5 / 12 PHE A  67
GLU A 131
VAL A 129
PHE A  88
GLY A 147
 None
 1.27A 5f9zB-2vreA:
undetectable		 5f9zB-2vreA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		5 / 11 THR A 154
ALA A 155
VAL A 141
GLY A 147
GLY A 148
 None
 0.90A 5lf7K-2vreA:
undetectable
5lf7L-2vreA:
undetectable		 5lf7K-2vreA:
20.31
5lf7L-2vreA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens) 		5 / 11 THR A 154
ALA A 155
VAL A 141
GLY A 147
GLY A 148
 None
 0.90A 5lf7Y-2vreA:
undetectable
5lf7Z-2vreA:
undetectable		 5lf7Y-2vreA:
20.31
5lf7Z-2vreA:
19.33