SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vri'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 2vri NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
NL63) 		4 / 7 ASP A  47
GLY A  39
GLY A  40
GLN A  55
 None
 0.97A 1ekjE-2vriA:
undetectable
1ekjF-2vriA:
undetectable		 1ekjE-2vriA:
21.59
1ekjF-2vriA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2vri NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
NL63) 		5 / 10 GLY A  71
GLU A  34
VAL A  87
GLY A  88
HIS A  94
 None
 1.20A 1pwyE-2vriA:
undetectable		 1pwyE-2vriA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2vri NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
NL63) 		5 / 10 GLY A  71
GLU A  34
VAL A  87
GLY A  88
HIS A  94
 None
 1.21A 1v3qE-2vriA:
undetectable		 1v3qE-2vriA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2vri NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
NL63) 		3 / 3 LEU A  49
LEU A  76
MET A  75
 None
 0.56A 2itzA-2vriA:
undetectable		 2itzA-2vriA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2vri NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
NL63) 		3 / 3 ALA A  31
GLY A 121
SER A 130
 None
 0.38A 2ivuA-2vriA:
undetectable		 2ivuA-2vriA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2vri NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
NL63) 		5 / 10 ALA A 155
LEU A 131
LEU A 117
VAL A 147
PHE A   3
 None
 1.16A 3fl9E-2vriA:
undetectable		 3fl9E-2vriA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 2vri NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
NL63) 		5 / 12 LEU A 134
SER A 136
PHE A 135
ILE A 139
LEU A 107
 None
 1.24A 3ko0A-2vriA:
undetectable
3ko0B-2vriA:
undetectable
3ko0C-2vriA:
undetectable
3ko0D-2vriA:
undetectable		 3ko0A-2vriA:
21.43
3ko0B-2vriA:
21.43
3ko0C-2vriA:
21.43
3ko0D-2vriA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 2vri NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
NL63) 		5 / 11 LEU A 107
LEU A 134
SER A 136
PHE A 135
ILE A 139
 None
 1.21A 3ko0A-2vriA:
undetectable
3ko0B-2vriA:
undetectable
3ko0I-2vriA:
undetectable
3ko0J-2vriA:
undetectable		 3ko0A-2vriA:
21.43
3ko0B-2vriA:
21.43
3ko0I-2vriA:
21.43
3ko0J-2vriA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 2vri NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
NL63) 		5 / 12 ASP A  47
ASN A  30
VAL A  86
ILE A 106
ILE A  16
 None
 1.03A 3ohtA-2vriA:
undetectable
3ohtB-2vriA:
undetectable		 3ohtA-2vriA:
20.38
3ohtB-2vriA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2vri NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
NL63) 		3 / 3 VAL A  74
ALA A  72
PHE A  84
 None
 0.93A 4olbA-2vriA:
2.6		 4olbA-2vriA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2vri NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
NL63) 		3 / 3 VAL A  74
ALA A  72
PHE A  84
 None
 0.92A 4w5nA-2vriA:
2.7		 4w5nA-2vriA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 2vri NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
NL63) 		5 / 12 VAL A  42
VAL A  83
LEU A  76
LEU A  36
LEU A  54
 None
 1.10A 6ajiA-2vriA:
undetectable		 6ajiA-2vriA:
11.44