SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vrn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 2vrn PROTEASE I
(Deinococcus
radiodurans) 		3 / 3 ASP A  77
ASP A 184
ASP A  75
 None
 0.75A 1eizA-2vrnA:
3.1		 1eizA-2vrnA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 2vrn PROTEASE I
(Deinococcus
radiodurans) 		3 / 3 ASP A  77
ASP A 184
ASP A  75
 None
 0.77A 1ej0A-2vrnA:
2.7		 1ej0A-2vrnA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2vrn PROTEASE I
(Deinococcus
radiodurans) 		3 / 3 LYS A 109
ILE A 126
THR A 156
 None
 0.80A 1rx3A-2vrnA:
undetectable		 1rx3A-2vrnA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2vrn PROTEASE I
(Deinococcus
radiodurans) 		3 / 3 GLU A 123
THR A 124
LEU A  81
 None
 0.69A 1v8bC-2vrnA:
4.2		 1v8bC-2vrnA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 2vrn PROTEASE I
(Deinococcus
radiodurans) 		5 / 11 GLY A  84
THR A  85
GLU A  21
HIS A 116
GLY A  54
 CSO  A 115 ( 4.2A)
None
None
CSO  A 115 ( 3.9A)
None
 1.09A 2fn1A-2vrnA:
undetectable		 2fn1A-2vrnA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 2vrn PROTEASE I
(Deinococcus
radiodurans) 		5 / 11 GLY A  84
THR A  85
GLU A  21
HIS A 116
GLY A  54
 CSO  A 115 ( 4.2A)
None
None
CSO  A 115 ( 3.9A)
None
 1.08A 2fn1B-2vrnA:
undetectable		 2fn1B-2vrnA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 2vrn PROTEASE I
(Deinococcus
radiodurans) 		4 / 5 PHE A 180
SER A  43
PHE A 172
ILE A  49
 None
 1.25A 2v0mD-2vrnA:
undetectable		 2v0mD-2vrnA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 2vrn PROTEASE I
(Deinococcus
radiodurans) 		5 / 9 LEU A 121
ILE A 126
GLY A 125
LEU A  81
GLU A 123
 None
 1.04A 3ai9X-2vrnA:
undetectable		 3ai9X-2vrnA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 2vrn PROTEASE I
(Deinococcus
radiodurans) 		4 / 6 ALA A 113
SER A 134
THR A 162
VAL A 160
 None
CSO  A 115 ( 4.5A)
None
None
 0.96A 3d2tB-2vrnA:
undetectable		 3d2tB-2vrnA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2vrn PROTEASE I
(Deinococcus
radiodurans) 		3 / 3 ASP A  77
ASP A 184
ASP A  75
 None
 0.69A 3douA-2vrnA:
undetectable		 3douA-2vrnA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 2vrn PROTEASE I
(Deinococcus
radiodurans) 		5 / 11 ALA A 107
GLY A 108
TYR A 105
ALA A  13
TYR A  76
 None
 1.49A 3qxyB-2vrnA:
undetectable
3qxyQ-2vrnA:
undetectable		 3qxyB-2vrnA:
18.71
3qxyQ-2vrnA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2vrn PROTEASE I
(Deinococcus
radiodurans) 		3 / 3 LYS A 109
ILE A 126
THR A 156
 None
 0.82A 4gh8A-2vrnA:
undetectable		 4gh8A-2vrnA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 2vrn PROTEASE I
(Deinococcus
radiodurans) 		5 / 12 ILE A  12
ALA A  34
VAL A 177
ILE A  32
PRO A  28
 None
 1.46A 5mlmA-2vrnA:
4.3		 5mlmA-2vrnA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 2vrn PROTEASE I
(Deinococcus
radiodurans) 		5 / 10 GLU A  24
GLY A  83
GLY A  84
ILE A 114
PRO A 118
 CSO  A 115 ( 3.2A)
CSO  A 115 ( 4.0A)
CSO  A 115 ( 4.2A)
CSO  A 115 ( 3.6A)
CSO  A 115 ( 4.3A)
 0.29A 6e5zA-2vrnA:
25.9		 6e5zA-2vrnA:
29.95