SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vro'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 11 LEU A 209
ALA A 169
LEU A 109
LEU A  69
VAL A 199
 None
 1.16A 1ictA-2vroA:
undetectable
1ictC-2vroA:
undetectable		 1ictA-2vroA:
12.78
1ictC-2vroA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A 105
LEU A 204
LEU A  69
THR A 191
LEU A 209
 None
 1.18A 1jipA-2vroA:
undetectable		 1jipA-2vroA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		3 / 3 ASP A 101
GLU A 257
ARG A 300
 None
 0.82A 1wopA-2vroA:
undetectable		 1wopA-2vroA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 11 VAL A 387
ALA A 393
LEU A 396
ARG A 301
SER A 263
 None
 1.26A 2bxgA-2vroA:
undetectable		 2bxgA-2vroA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 PHE A 280
LEU A 313
LEU A 384
SER A 407
ALA A 409
 None
 1.12A 2bxpA-2vroA:
undetectable		 2bxpA-2vroA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		4 / 5 ASP A 269
SER A 442
LEU A 420
ARG A 450
 None
 1.16A 2j2pA-2vroA:
undetectable
2j2pB-2vroA:
undetectable		 2j2pA-2vroA:
17.20
2j2pB-2vroA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		4 / 7 GLU A 400
GLY A 403
GLN A 343
PHE A 158
 None
None
NDP  A1523 ( 4.6A)
NDP  A1523 ( 4.6A)
 0.93A 2qmzA-2vroA:
3.0
2qmzB-2vroA:
undetectable		 2qmzA-2vroA:
17.75
2qmzB-2vroA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		4 / 8 ILE A 299
PHE A 280
LEU A 384
LEU A 316
 None
 0.82A 2w98B-2vroA:
3.3		 2w98B-2vroA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 PHE A 277
PRO A 272
ALA A 264
ALA A 302
LEU A 313
 None
 1.23A 2x2nB-2vroA:
undetectable		 2x2nB-2vroA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 PHE A 277
PRO A 272
ALA A 264
ALA A 302
LEU A 313
 None
 1.24A 2x2nC-2vroA:
undetectable		 2x2nC-2vroA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		3 / 3 ASP A 389
THR A 415
GLU A 306
 None
 0.76A 2zifB-2vroA:
undetectable		 2zifB-2vroA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		3 / 3 PHE A 158
SER A 340
GLN A 343
 NDP  A1523 ( 4.6A)
None
NDP  A1523 ( 4.6A)
 0.92A 3smtA-2vroA:
undetectable		 3smtA-2vroA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		4 / 8 VAL A 479
TRP A 163
HIS A 485
PHE A 160
 ETE  A1524 (-4.2A)
ETE  A1524 (-3.9A)
None
ETE  A1524 (-4.0A)
 1.49A 3v35A-2vroA:
undetectable		 3v35A-2vroA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		4 / 7 ILE A 465
GLN A 473
GLY A 475
SER A 439
 None
 0.99A 4a3uB-2vroA:
undetectable		 4a3uB-2vroA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		3 / 3 LYS A  79
LEU A  75
ALA A  78
 None
 0.84A 4iizA-2vroA:
undetectable		 4iizA-2vroA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		3 / 3 PHE A 231
ILE A 155
ASP A 227
 None
NDP  A1523 (-4.5A)
None
 0.76A 5cswB-2vroA:
undetectable		 5cswB-2vroA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A 104
THR A 108
TRP A 163
CYH A 296
THR A 297
 ETE  A1524 (-3.5A)
None
ETE  A1524 (-3.9A)
None
ETE  A1524 ( 4.1A)
 1.11A 5fhzA-2vroA:
42.3		 5fhzA-2vroA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		6 / 12 GLY A 104
ASN A 159
TRP A 163
GLU A 257
CYH A 296
THR A 297
 ETE  A1524 (-3.5A)
None
ETE  A1524 (-3.9A)
None
None
ETE  A1524 ( 4.1A)
 1.21A 5fhzD-2vroA:
41.3		 5fhzD-2vroA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A 105
ASN A 159
GLU A 257
CYH A 296
THR A 297
 None
None
None
None
ETE  A1524 ( 4.1A)
 1.18A 5fhzD-2vroA:
41.3		 5fhzD-2vroA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 ALA A 152
PRO A 171
THR A 108
GLY A 164
SER A 230
 None
 1.40A 5hfjH-2vroA:
3.5		 5hfjH-2vroA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		3 / 3 VAL A 100
GLU A 283
GLU A 287
 None
 0.81A 5jsdB-2vroA:
undetectable
5jsdC-2vroA:
undetectable		 5jsdB-2vroA:
21.36
5jsdC-2vroA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 VAL A 228
ASP A 227
ALA A 172
GLY A  53
LEU A  57
 None
 1.27A 5m54E-2vroA:
2.2		 5m54E-2vroA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 VAL A 228
ASP A 227
ALA A 172
GLY A  54
LEU A  57
 None
 0.96A 5m54E-2vroA:
2.2		 5m54E-2vroA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		4 / 5 ARG A 431
THR A 394
HIS A 397
ALA A 393
 None
 1.43A 5mfxA-2vroA:
undetectable		 5mfxA-2vroA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		4 / 6 ARG A  68
ARG A  65
ALA A 208
PRO A 205
 None
 1.38A 5odqA-2vroA:
3.7		 5odqA-2vroA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		4 / 5 ASP A 103
PRO A 481
GLU A 167
THR A 108
 None
 1.30A 5uxcA-2vroA:
undetectable		 5uxcA-2vroA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 ALA A 381
LEU A 320
PHE A 280
VAL A 304
ALA A 361
 None
 0.99A 6djzC-2vroA:
undetectable		 6djzC-2vroA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 ALA A 381
LEU A 320
PHE A 280
VAL A 304
LEU A 360
 None
 1.15A 6djzC-2vroA:
undetectable		 6djzC-2vroA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2vro ALDEHYDE
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 7 TYR A 111
ILE A 106
GLY A 498
ARG A  68
ALA A 170
 None
 1.09A 6hd6B-2vroA:
undetectable		 6hd6B-2vroA:
10.83