SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vrs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2vrs SIGMA-C CAPSID
PROTEIN
(Avian
orthoreovirus) 		4 / 7 ILE A 303
PHE A 301
ARG A 321
MET A 231
 None
 1.04A 3ag4N-2vrsA:
undetectable
3ag4W-2vrsA:
undetectable		 3ag4N-2vrsA:
18.48
3ag4W-2vrsA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2vrs SIGMA-C CAPSID
PROTEIN
(Avian
orthoreovirus) 		5 / 10 LEU A 237
ILE A 214
GLY A 235
THR A 281
PHE A 280
 None
 0.91A 4fakA-2vrsA:
undetectable		 4fakA-2vrsA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2vrs SIGMA-C CAPSID
PROTEIN
(Avian
orthoreovirus) 		5 / 12 ASP A 325
LEU A 250
PHE A 301
ALA A 272
PHE A 274
 None
 1.00A 4retA-2vrsA:
undetectable		 4retA-2vrsA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2vrs SIGMA-C CAPSID
PROTEIN
(Avian
orthoreovirus) 		3 / 3 ALA A 127
ASN A 130
LEU A 131
 None
 0.37A 5i1nB-2vrsA:
undetectable		 5i1nB-2vrsA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2vrs SIGMA-C CAPSID
PROTEIN
(Avian
orthoreovirus) 		3 / 3 ALA A 127
ASN A 130
LEU A 131
 None
 0.41A 5i1oA-2vrsA:
undetectable		 5i1oA-2vrsA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2vrs SIGMA-C CAPSID
PROTEIN
(Avian
orthoreovirus) 		3 / 3 ALA A 127
ASN A 130
LEU A 131
 None
 0.47A 5i1pD-2vrsA:
undetectable		 5i1pD-2vrsA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 2vrs SIGMA-C CAPSID
PROTEIN
(Avian
orthoreovirus) 		5 / 12 VAL A 218
ILE A 324
PRO A 265
LEU A 263
LEU A 250
 None
 1.17A 5im2A-2vrsA:
undetectable		 5im2A-2vrsA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2vrs SIGMA-C CAPSID
PROTEIN
(Avian
orthoreovirus) 		3 / 3 MET A 198
ASP A 259
ARG A 299
 None
None
GOL  A1327 (-3.9A)
 0.96A 5z6jA-2vrsA:
undetectable		 5z6jA-2vrsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2vrs SIGMA-C CAPSID
PROTEIN
(Avian
orthoreovirus) 		3 / 3 MET A 198
ASP A 259
ARG A 299
 None
None
GOL  A1327 (-3.9A)
 0.94A 5z6kA-2vrsA:
undetectable		 5z6kA-2vrsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2vrs SIGMA-C CAPSID
PROTEIN
(Avian
orthoreovirus) 		5 / 12 LEU A 237
VAL A 239
GLY A 209
PHE A 305
VAL A 278
 None
 1.27A 6a94A-2vrsA:
undetectable		 6a94A-2vrsA:
20.26