SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vrt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 2vrt RIBONUCLEASE E
(Escherichia
coli) 		4 / 6 LEU A 166
LEU A 129
PRO A 131
MET A 130
 None
 1.23A 1hz4A-2vrtA:
undetectable		 1hz4A-2vrtA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vrt RIBONUCLEASE E
(Escherichia
coli) 		5 / 10 ILE A 304
PHE A 347
SER A 377
ILE A 376
ILE A 345
 None
 1.21A 1j3jA-2vrtA:
undetectable		 1j3jA-2vrtA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2vrt RIBONUCLEASE E
(Escherichia
coli) 		4 / 7 VAL A  16
VAL A 236
LEU A 239
LEU A  14
 None
 0.89A 1pthB-2vrtA:
undetectable		 1pthB-2vrtA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 2vrt RIBONUCLEASE E
(Escherichia
coli) 		4 / 4 ASP A 183
LEU A 129
LEU A 122
LEU A 127
 None
 1.12A 1u18A-2vrtA:
undetectable		 1u18A-2vrtA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 2vrt RIBONUCLEASE E
(Escherichia
coli) 		3 / 3 ARG A 169
ARG A 371
ARG A 219
 U  F   1 ( 3.4A)
None
None
 0.83A 2jb7A-2vrtA:
undetectable
2jb7B-2vrtA:
undetectable
2jb7C-2vrtA:
undetectable		 2jb7A-2vrtA:
16.57
2jb7B-2vrtA:
16.57
2jb7C-2vrtA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 2vrt RIBONUCLEASE E
(Escherichia
coli) 		3 / 3 ARG A 219
ARG A 169
ARG A 371
 None
U  F   1 ( 3.4A)
None
 0.82A 2jb7A-2vrtA:
undetectable
2jb7B-2vrtA:
undetectable
2jb7C-2vrtA:
undetectable		 2jb7A-2vrtA:
16.57
2jb7B-2vrtA:
16.57
2jb7C-2vrtA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 2vrt RIBONUCLEASE E
(Escherichia
coli) 		3 / 3 ARG A 371
ARG A 219
ARG A 169
 None
None
U  F   1 ( 3.4A)
 0.80A 2jb7A-2vrtA:
undetectable
2jb7B-2vrtA:
undetectable
2jb7C-2vrtA:
undetectable		 2jb7A-2vrtA:
16.57
2jb7B-2vrtA:
16.57
2jb7C-2vrtA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 2vrt RIBONUCLEASE E
(Escherichia
coli) 		4 / 6 LEU A 334
VAL A 367
ILE A 374
ILE A 343
 None
 0.84A 2piwA-2vrtA:
undetectable		 2piwA-2vrtA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2vrt RIBONUCLEASE E
(Escherichia
coli) 		4 / 5 ARG A 357
LEU A 324
ILE A 345
PHE A 347
 None
 1.09A 3ln1D-2vrtA:
undetectable		 3ln1D-2vrtA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 2vrt RIBONUCLEASE E
(Escherichia
coli) 		5 / 12 ILE A  73
ALA A  55
LEU A  68
VAL A  58
ALA A 203
 None
 1.28A 3ozuA-2vrtA:
2.3		 3ozuA-2vrtA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2vrt RIBONUCLEASE E
(Escherichia
coli) 		4 / 8 ALA A 307
GLY A 289
GLU A 325
THR A 322
 None
 0.91A 3rglA-2vrtA:
undetectable		 3rglA-2vrtA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2vrt RIBONUCLEASE E
(Escherichia
coli) 		4 / 8 SER A 267
GLU A 272
ILE A 231
VAL A 236
 None
 0.98A 4dx7B-2vrtA:
undetectable		 4dx7B-2vrtA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 2vrt RIBONUCLEASE E
(Escherichia
coli) 		6 / 12 ASP A 303
LEU A 384
ILE A 343
LEU A 299
ILE A 291
ILE A 293
 None
 1.38A 4odrA-2vrtA:
undetectable
4odrB-2vrtA:
undetectable		 4odrA-2vrtA:
14.23
4odrB-2vrtA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2vrt RIBONUCLEASE E
(Escherichia
coli) 		5 / 9 ILE A 291
LEU A 285
ILE A 304
ILE A 345
ALA A 366
 None
 1.01A 5nunA-2vrtA:
undetectable		 5nunA-2vrtA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2vrt RIBONUCLEASE E
(Escherichia
coli) 		4 / 8 ALA A  74
GLU A  76
ILE A 101
ILE A  41
 None
 0.96A 5t8sA-2vrtA:
undetectable		 5t8sA-2vrtA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2vrt RIBONUCLEASE E
(Escherichia
coli) 		4 / 7 ALA A  74
GLU A  76
ILE A 101
ILE A  41
 None
 0.94A 6fbnA-2vrtA:
undetectable		 6fbnA-2vrtA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vrt RIBONUCLEASE E
(Escherichia
coli) 		5 / 12 GLY A  21
GLN A  22
TYR A 259
LEU A 230
HIS A 268
 None
 1.26A 6md4A-2vrtA:
undetectable		 6md4A-2vrtA:
10.37