SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vsg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 2vsg VARIANT SURFACE
GLYCOPROTEIN ILTAT
1.24
(Trypanosoma
brucei) 		5 / 11 SER A  33
ASN A  32
MET A  29
GLY A 256
GLN A 255
 None
 1.34A 1jr1A-2vsgA:
undetectable		 1jr1A-2vsgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2vsg VARIANT SURFACE
GLYCOPROTEIN ILTAT
1.24
(Trypanosoma
brucei) 		3 / 3 VAL A 157
ASP A 156
GLU A  15
 None
 0.75A 2qeuA-2vsgA:
undetectable		 2qeuA-2vsgA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2vsg VARIANT SURFACE
GLYCOPROTEIN ILTAT
1.24
(Trypanosoma
brucei) 		5 / 12 PHE A 306
ALA A  66
THR A  73
ALA A 275
ASP A 278
 None
 1.19A 2qm9A-2vsgA:
undetectable		 2qm9A-2vsgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 2vsg VARIANT SURFACE
GLYCOPROTEIN ILTAT
1.24
(Trypanosoma
brucei) 		4 / 7 GLY A 208
LEU A 183
PHE A 184
THR A 109
 None
 0.91A 2vl2B-2vsgA:
undetectable		 2vl2B-2vsgA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2vsg VARIANT SURFACE
GLYCOPROTEIN ILTAT
1.24
(Trypanosoma
brucei) 		3 / 3 GLY A   4
GLY A 174
GLY A 176
 None
 0.39A 3bogC-2vsgA:
undetectable		 3bogC-2vsgA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 2vsg VARIANT SURFACE
GLYCOPROTEIN ILTAT
1.24
(Trypanosoma
brucei) 		5 / 10 ILE A 107
GLY A 106
GLY A 208
LEU A 209
PRO A 223
 None
 1.01A 3em4V-2vsgA:
undetectable		 3em4V-2vsgA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2vsg VARIANT SURFACE
GLYCOPROTEIN ILTAT
1.24
(Trypanosoma
brucei) 		5 / 12 PHE A 306
GLY A 307
ASN A 312
ILE A 313
ALA A  61
 None
 1.03A 3hs6B-2vsgA:
undetectable		 3hs6B-2vsgA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 2vsg VARIANT SURFACE
GLYCOPROTEIN ILTAT
1.24
(Trypanosoma
brucei) 		4 / 6 LEU A  35
SER A  37
PHE A  38
ILE A  82
 None
 0.96A 3ko0S-2vsgA:
undetectable		 3ko0S-2vsgA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2vsg VARIANT SURFACE
GLYCOPROTEIN ILTAT
1.24
(Trypanosoma
brucei) 		5 / 8 SER A  33
ASN A  32
MET A  29
GLY A 256
GLN A 255
 None
 1.34A 4af0A-2vsgA:
undetectable		 4af0A-2vsgA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2vsg VARIANT SURFACE
GLYCOPROTEIN ILTAT
1.24
(Trypanosoma
brucei) 		5 / 10 SER A  33
ASN A  32
MET A  29
GLY A 256
GLN A 255
 None
 1.32A 4af0B-2vsgA:
undetectable		 4af0B-2vsgA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2vsg VARIANT SURFACE
GLYCOPROTEIN ILTAT
1.24
(Trypanosoma
brucei) 		5 / 12 ILE A 107
GLY A 106
GLU A   8
ALA A  18
SER A 167
 None
 1.26A 5igvA-2vsgA:
undetectable		 5igvA-2vsgA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 2vsg VARIANT SURFACE
GLYCOPROTEIN ILTAT
1.24
(Trypanosoma
brucei) 		3 / 3 GLU A  60
LEU A  64
ARG A  65
 None
 0.68A 6d8fA-2vsgA:
undetectable		 6d8fA-2vsgA:
19.48