SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vsi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 10 TYR A   3
ILE A  49
ARG A  75
ILE A 127
ILE A 123
 None
 1.34A 2dm6A-2vsiA:
undetectable
2dm6B-2vsiA:
2.5		 2dm6A-2vsiA:
20.17
2dm6B-2vsiA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 ILE A  34
PRO A  31
PHE A  24
ILE A   6
 None
 1.14A 2hjhA-2vsiA:
undetectable		 2hjhA-2vsiA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 6 LEU A  33
ILE A   6
ILE A 127
LEU A 120
 None
 0.93A 2xkwB-2vsiA:
undetectable		 2xkwB-2vsiA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 9 ALA A  95
ASP A  97
ILE A  93
GLY A   5
ILE A   6
 None
 1.09A 3nuoA-2vsiA:
undetectable		 3nuoA-2vsiA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 ASP A 137
VAL A 139
GLY A 167
ASP A 195
 None
 1.20A 3w9tA-2vsiA:
undetectable		 3w9tA-2vsiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 ASP A 137
VAL A 139
GLY A 167
ASP A 195
 None
 1.19A 3w9tB-2vsiA:
undetectable		 3w9tB-2vsiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 ASP A 137
VAL A 139
GLY A 167
ASP A 195
 None
 1.20A 3w9tC-2vsiA:
undetectable		 3w9tC-2vsiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 ASP A 137
VAL A 139
GLY A 167
ASP A 195
 None
 1.20A 3w9tD-2vsiA:
undetectable		 3w9tD-2vsiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 ASP A 137
VAL A 139
GLY A 167
ASP A 195
 None
 1.20A 3w9tE-2vsiA:
undetectable		 3w9tE-2vsiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 ASP A 137
VAL A 139
GLY A 167
ASP A 195
 None
 1.20A 3w9tF-2vsiA:
undetectable		 3w9tF-2vsiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 ASP A 137
VAL A 139
GLY A 167
ASP A 195
 None
 1.19A 3w9tG-2vsiA:
undetectable		 3w9tG-2vsiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 LEU A  71
VAL A  65
ASP A  66
 None
 0.53A 4y8wC-2vsiA:
undetectable		 4y8wC-2vsiA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 10 LEU A   7
ARG A  85
ALA A 196
PHE A 173
VAL A 108
 CDF  A1234 (-3.8A)
CDF  A1234 (-3.5A)
None
None
None
 1.35A 5m0oA-2vsiA:
undetectable		 5m0oA-2vsiA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 LEU A   7
ARG A  85
ALA A 196
PHE A 173
 CDF  A1234 (-3.8A)
CDF  A1234 (-3.5A)
None
None
 0.83A 5m0oC-2vsiA:
undetectable		 5m0oC-2vsiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 10 ILE A  92
THR A  79
ILE A  78
ILE A  77
ILE A  76
 None
 0.99A 5murE-2vsiA:
undetectable		 5murE-2vsiA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 ALA A   4
ILE A  92
ALA A  95
ILE A  96
 None
 0.40A 5mvmA-2vsiA:
undetectable
5mvmB-2vsiA:
undetectable		 5mvmA-2vsiA:
16.50
5mvmB-2vsiA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 ILE A 107
GLU A 105
ASP A 134
ASN A 132
 None
 0.94A 5n5dA-2vsiA:
3.4		 5n5dA-2vsiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 ILE A 118
THR A 119
PRO A 170
 None
 0.60A 6ncsA-2vsiA:
3.0		 6ncsA-2vsiA:
24.51