SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vsq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 10 MET A 571
GLY A 530
GLU A 526
GLU A 570
ILE A 531
 None
 1.42A 1pw7A-2vsqA:
undetectable		 1pw7A-2vsqA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 9 MET A 571
GLY A 530
GLU A 526
GLU A 570
ILE A 531
 None
 1.44A 1pw7B-2vsqA:
undetectable		 1pw7B-2vsqA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 10 ALA A1033
ILE A 967
GLY A 968
GLY A 991
ILE A 990
 None
 0.96A 1sdvA-2vsqA:
undetectable		 1sdvA-2vsqA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 12 LEU A1026
THR A1008
LEU A 985
GLY A1000
HIS A1002
 None
 1.31A 1v8bD-2vsqA:
4.4		 1v8bD-2vsqA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 11 MET A 571
GLY A 530
GLU A 526
GLU A 570
ILE A 531
 None
 1.42A 1vhwA-2vsqA:
undetectable
1vhwD-2vsqA:
undetectable		 1vhwA-2vsqA:
11.48
1vhwD-2vsqA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 11 MET A 571
GLY A 530
GLU A 526
GLU A 570
ILE A 531
 None
 1.44A 1vhwC-2vsqA:
undetectable
1vhwE-2vsqA:
undetectable		 1vhwC-2vsqA:
11.48
1vhwE-2vsqA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 11 MET A 571
GLY A 530
GLU A 526
GLU A 570
ILE A 531
 None
 1.43A 1vhwA-2vsqA:
undetectable
1vhwD-2vsqA:
undetectable		 1vhwA-2vsqA:
11.48
1vhwD-2vsqA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 11 MET A 571
GLY A 530
GLU A 526
GLU A 570
ILE A 531
 None
 1.43A 1vhwC-2vsqA:
undetectable
1vhwE-2vsqA:
undetectable		 1vhwC-2vsqA:
11.48
1vhwE-2vsqA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		3 / 3 LEU A  83
PHE A   4
ARG A 128
 None
 0.89A 1xdkB-2vsqA:
undetectable		 1xdkB-2vsqA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 12 LEU A 692
LEU A 675
SER A 652
LEU A 651
ASP A 664
 None
 1.12A 2c12C-2vsqA:
undetectable		 2c12C-2vsqA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 11 LEU A 692
LEU A 675
SER A 652
LEU A 651
ASP A 664
 None
 1.17A 2c12F-2vsqA:
undetectable		 2c12F-2vsqA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 7 ARG A 987
GLU A 983
LYS A1005
ALA A1009
 None
 1.19A 2ejgA-2vsqA:
undetectable		 2ejgA-2vsqA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 12 ILE A 790
LEU A 806
GLY A 843
ALA A 857
ALA A 846
 None
 0.90A 2oc8A-2vsqA:
undetectable		 2oc8A-2vsqA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		3 / 3 LEU A 683
ASN A 655
ARG A 523
 None
 0.71A 2qhfA-2vsqA:
undetectable		 2qhfA-2vsqA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 12 ILE A 553
TYR A 666
PHE A 661
ALA A 482
LEU A 532
 None
 1.33A 2x2nD-2vsqA:
undetectable		 2x2nD-2vsqA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 12 ILE A 553
TYR A 666
PHE A 661
ALA A 673
LEU A 532
 None
 1.27A 2x2nD-2vsqA:
undetectable		 2x2nD-2vsqA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 8 VAL A1067
SER A1217
TYR A1196
VAL A1172
 None
 1.30A 2y05A-2vsqA:
2.7
2y05B-2vsqA:
3.8		 2y05A-2vsqA:
14.63
2y05B-2vsqA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 7 GLU A 872
GLU A 874
TYR A 856
ARG A 731
 None
 1.26A 2zt7A-2vsqA:
undetectable		 2zt7A-2vsqA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		3 / 3 MET A 973
GLU A1094
ASP A1090
 None
 1.06A 3a25A-2vsqA:
undetectable		 3a25A-2vsqA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		3 / 3 SER A 616
GLY A 620
GLY A 947
 None
 0.37A 3bogA-2vsqA:
undetectable
3bogC-2vsqA:
undetectable		 3bogA-2vsqA:
undetectable
3bogC-2vsqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 8 ALA A 821
ASP A 822
GLY A 816
ILE A 626
 None
 0.85A 3el9A-2vsqA:
undetectable		 3el9A-2vsqA:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 7 ARG A  77
TYR A  14
ILE A 187
GLN A  80
 None
 1.04A 3hgxA-2vsqA:
undetectable		 3hgxA-2vsqA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 12 GLU A 446
LEU A 388
THR A 214
PRO A 799
GLY A 801
 None
 1.22A 3j6pB-2vsqA:
undetectable		 3j6pB-2vsqA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 8 LEU A1081
SER A1078
LEU A1215
ILE A1061
 None
 0.84A 3ln1A-2vsqA:
undetectable		 3ln1A-2vsqA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 7 LEU A1081
SER A1078
LEU A1215
ILE A1061
 None
 0.83A 3ln1B-2vsqA:
undetectable		 3ln1B-2vsqA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 11 PRO A 600
ASP A 599
ASN A 500
VAL A 474
ALA A 473
 None
 1.28A 3n23A-2vsqA:
undetectable		 3n23A-2vsqA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 11 PRO A 600
ASP A 599
ASN A 500
VAL A 474
ALA A 473
 None
 1.28A 3n23C-2vsqA:
undetectable		 3n23C-2vsqA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 8 ARG A  77
TYR A  14
ILE A 187
GLN A  80
 None
 1.04A 3remB-2vsqA:
undetectable		 3remB-2vsqA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 6 SER A 325
GLN A 324
SER A 328
GLN A 332
 None
 1.39A 3si7C-2vsqA:
0.4
3si7D-2vsqA:
0.0		 3si7C-2vsqA:
13.17
3si7D-2vsqA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 6 SER A 328
GLN A 332
SER A 325
GLN A 324
 None
 1.39A 3si7C-2vsqA:
0.4
3si7D-2vsqA:
0.0		 3si7C-2vsqA:
13.17
3si7D-2vsqA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 11 PHE A 665
PHE A 661
ILE A 531
GLY A 530
LEU A 483
 None
 1.16A 3t3rA-2vsqA:
undetectable		 3t3rA-2vsqA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		6 / 12 GLY A 533
ILE A 531
ILE A 529
ARG A 504
ASP A 599
LEU A 495
 None
 1.34A 3uj6A-2vsqA:
undetectable		 3uj6A-2vsqA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		3 / 3 PRO A 394
ASP A 362
GLU A 356
 None
 0.79A 3v4tC-2vsqA:
undetectable		 3v4tC-2vsqA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		3 / 3 TYR A 485
MET A 701
LEU A 689
 None
 0.92A 3vw1D-2vsqA:
undetectable		 3vw1D-2vsqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 12 LEU A 926
ILE A 871
GLN A 863
ILE A 876
TYR A 856
 None
 1.33A 4a79A-2vsqA:
undetectable		 4a79A-2vsqA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 12 GLY A 538
GLY A 514
SER A 515
LEU A 532
GLY A 530
 None
 1.24A 4blvB-2vsqA:
undetectable		 4blvB-2vsqA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		3 / 3 TYR A 929
HIS A 869
ARG A 867
 None
 0.90A 4e7bC-2vsqA:
undetectable		 4e7bC-2vsqA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 11 ALA A 247
PHE A 355
LEU A 390
VAL A 261
THR A 252
 None
 1.38A 4eilA-2vsqA:
undetectable		 4eilA-2vsqA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 11 ALA A 247
PHE A 355
LEU A 390
VAL A 261
THR A 252
 None
 1.38A 4eilC-2vsqA:
undetectable		 4eilC-2vsqA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 11 ALA A 247
PHE A 355
LEU A 390
VAL A 261
THR A 252
 None
 1.35A 4eilE-2vsqA:
2.0		 4eilE-2vsqA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 12 LEU A 585
LEU A 566
LEU A 519
ALA A 518
ALA A 539
 None
 0.95A 4fn9A-2vsqA:
undetectable		 4fn9A-2vsqA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 7 TYR A 929
HIS A 869
ILE A 871
PRO A 927
 None
 0.98A 4g5jA-2vsqA:
0.7		 4g5jA-2vsqA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 12 LEU A 806
ALA A 786
ILE A 779
ASP A 659
GLY A 754
 None
None
None
LEU  A2291 (-4.3A)
LEU  A2291 ( 4.7A)
 1.09A 4hfpB-2vsqA:
undetectable		 4hfpB-2vsqA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		6 / 12 ALA A 247
PHE A 355
ILE A 400
LEU A 390
VAL A 261
THR A 252
 None
 1.31A 4kfjB-2vsqA:
undetectable		 4kfjB-2vsqA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 12 PHE A 215
ALA A 216
PHE A 413
LEU A 417
GLY A 804
 None
 1.21A 4kykA-2vsqA:
undetectable
4kykB-2vsqA:
undetectable		 4kykA-2vsqA:
8.93
4kykB-2vsqA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 5 PHE A 935
PHE A 937
LEU A 954
PRO A 942
 None
 1.33A 4o8zA-2vsqA:
undetectable		 4o8zA-2vsqA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 6 LEU A 297
LEU A  23
PHE A  70
THR A  68
VAL A  65
 None
 1.36A 4udaA-2vsqA:
undetectable		 4udaA-2vsqA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 7 LEU A 711
LEU A 707
GLU A 687
LEU A 689
 None
 0.78A 4wg0L-2vsqA:
undetectable
4wg0M-2vsqA:
undetectable		 4wg0L-2vsqA:
1.46
4wg0M-2vsqA:
1.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_1
(MEDI2452 HEAVY CHAIN
MEDI2452 LIGHT CHAIN)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 11 SER A 263
ILE A 266
SER A 272
PRO A 303
LEU A 317
 None
 1.15A 5albH-2vsqA:
1.4		 5albH-2vsqA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 4 LEU A  83
TYR A 183
PRO A 126
ILE A 125
 None
 1.39A 5esgA-2vsqA:
undetectable		 5esgA-2vsqA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 8 PHE A 155
ILE A  39
LEU A  52
MET A  56
 None
 0.83A 5esjA-2vsqA:
undetectable		 5esjA-2vsqA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 5 HIS A 509
VAL A 534
GLY A 512
ALA A 537
 None
 1.03A 5hwaA-2vsqA:
undetectable		 5hwaA-2vsqA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 6 GLY A 634
ASP A 664
ILE A 531
TYR A 611
 None
 1.12A 5iwuA-2vsqA:
undetectable		 5iwuA-2vsqA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 12 TYR A 666
THR A 627
THR A 628
ALA A 610
GLY A 758
 None
 0.86A 5lf7V-2vsqA:
undetectable
5lf7b-2vsqA:
undetectable		 5lf7V-2vsqA:
10.60
5lf7b-2vsqA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 12 TYR A 666
THR A 627
THR A 628
ALA A 610
GLY A 758
 None
 0.86A 5lf7H-2vsqA:
undetectable
5lf7N-2vsqA:
undetectable		 5lf7H-2vsqA:
10.60
5lf7N-2vsqA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 12 TYR A 666
THR A 627
THR A 628
ALA A 610
GLY A 812
 None
 1.05A 5lf7H-2vsqA:
undetectable
5lf7N-2vsqA:
undetectable		 5lf7H-2vsqA:
10.60
5lf7N-2vsqA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 10 TYR A 753
ILE A 808
VAL A 788
THR A 763
ILE A 783
 None
 1.41A 5mvnD-2vsqA:
undetectable		 5mvnD-2vsqA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 10 TYR A 753
ILE A 808
VAL A 788
THR A 763
ILE A 783
 None
 1.31A 5mzrA-2vsqA:
undetectable		 5mzrA-2vsqA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 10 TYR A 753
ILE A 808
VAL A 788
THR A 763
ILE A 783
 None
 1.35A 5mzrC-2vsqA:
undetectable		 5mzrC-2vsqA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 8 TYR A 753
ILE A 808
THR A 763
ILE A 783
 None
 0.95A 5mzrE-2vsqA:
undetectable		 5mzrE-2vsqA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 8 LEU A 441
ARG A 268
LEU A 421
ILE A 266
 None
 0.98A 5v0vA-2vsqA:
1.0		 5v0vA-2vsqA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 10 LEU A 726
TYR A 641
ILE A 783
PHE A 761
LEU A 670
 None
 1.17A 5y7pD-2vsqA:
undetectable		 5y7pD-2vsqA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		5 / 10 LEU A 726
TYR A 641
ILE A 783
PHE A 761
LEU A 670
 None
 1.17A 5y7pH-2vsqA:
undetectable		 5y7pH-2vsqA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		6 / 12 ALA A 764
GLY A 780
THR A 853
LEU A 635
ASN A 751
PHE A 761
 None
 1.35A 5ybbA-2vsqA:
undetectable		 5ybbA-2vsqA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		3 / 3 TYR A 906
ASN A 950
LEU A 954
 None
 0.76A 6b58A-2vsqA:
undetectable		 6b58A-2vsqA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 6 ALA A 392
SER A 234
ILE A 429
PHE A 314
 None
 0.91A 6f8cA-2vsqA:
undetectable		 6f8cA-2vsqA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 2vsq SURFACTIN SYNTHETASE
SUBUNIT 3
(Bacillus
subtilis) 		4 / 5 SER A 282
VAL A 281
ASN A 300
PRO A 330
 None
 1.10A 6fi4A-2vsqA:
undetectable
6fi4B-2vsqA:
undetectable		 6fi4A-2vsqA:
12.01
6fi4B-2vsqA:
1.61