SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vsu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE
(Pseudomonas
fluorescens) 		3 / 3 GLU C  84
ILE C  85
ARG C  92
 None
 0.71A 1cd2A-2vsuC:
undetectable		 1cd2A-2vsuC:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE
(Pseudomonas
fluorescens) 		5 / 12 THR C 201
LEU C 125
PHE C 139
VAL C 113
ALA C 183
 None
 1.14A 1q23H-2vsuC:
undetectable
1q23I-2vsuC:
undetectable		 1q23H-2vsuC:
19.13
1q23I-2vsuC:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE
(Pseudomonas
fluorescens) 		5 / 12 LEU C  45
LEU C  57
TYR C 105
ALA C 127
ALA C 123
 None
 1.13A 2br4C-2vsuC:
undetectable		 2br4C-2vsuC:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE
(Pseudomonas
fluorescens) 		5 / 12 LEU C  45
LEU C  57
TYR C 105
ALA C 127
ALA C 123
 None
 1.13A 2br4D-2vsuC:
undetectable		 2br4D-2vsuC:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE
(Pseudomonas
fluorescens) 		5 / 12 LEU C  45
LEU C  57
TYR C 105
ALA C 127
ALA C 123
 None
 1.17A 2br4E-2vsuC:
undetectable		 2br4E-2vsuC:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE
(Pseudomonas
fluorescens) 		5 / 12 ALA C 123
GLY C 121
ALA C 157
THR C 161
CYH C 117
 None
 1.12A 2c49A-2vsuC:
undetectable		 2c49A-2vsuC:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE
(Pseudomonas
fluorescens) 		5 / 10 LEU C  24
ASN C 114
VAL C 113
GLY C 115
LEU C  59
 None
 1.19A 3lp1A-2vsuC:
undetectable		 3lp1A-2vsuC:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE
(Pseudomonas
fluorescens) 		4 / 4 PRO C  83
LEU C  86
ILE C  90
ARG C  39
 None
 1.45A 4f4dA-2vsuC:
undetectable		 4f4dA-2vsuC:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE
(Pseudomonas
fluorescens) 		4 / 6 TRP C   8
ILE C  23
THR C  60
ASP C  51
 None
 1.15A 4iaqA-2vsuC:
undetectable		 4iaqA-2vsuC:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE
(Pseudomonas
fluorescens) 		5 / 12 ALA C  62
LEU C 197
GLY C  69
LEU C 125
PHE C 139
 None
 1.14A 4kykA-2vsuC:
undetectable
4kykB-2vsuC:
undetectable		 4kykA-2vsuC:
20.64
4kykB-2vsuC:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE
(Pseudomonas
fluorescens) 		5 / 12 MET C  41
VAL C  44
LEU C  45
ALA C  20
LEU C  57
 None
 0.70A 4o1zB-2vsuC:
undetectable		 4o1zB-2vsuC:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE
(Pseudomonas
fluorescens) 		4 / 8 LEU C 102
GLY C 121
THR C  67
LEU C  24
 None
 0.91A 5eseA-2vsuC:
undetectable		 5eseA-2vsuC:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE
(Pseudomonas
fluorescens) 		4 / 5 LEU C 101
THR C  47
ARG C  39
ARG C  26
 None
 1.22A 6ew0B-2vsuC:
undetectable		 6ew0B-2vsuC:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE
(Pseudomonas
fluorescens) 		4 / 5 LEU C 101
THR C  47
ARG C  39
ARG C  26
 None
 1.22A 6ew0D-2vsuC:
undetectable		 6ew0D-2vsuC:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE
(Pseudomonas
fluorescens) 		4 / 5 LEU C 101
THR C  47
ARG C  39
ARG C  26
 None
 1.23A 6ew0H-2vsuC:
undetectable		 6ew0H-2vsuC:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE
(Pseudomonas
fluorescens) 		4 / 5 LEU C 101
THR C  47
ARG C  39
ARG C  26
 None
 1.22A 6ew0I-2vsuC:
undetectable		 6ew0I-2vsuC:
15.56