SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vsx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 652
ALA E 656
LEU E 614
VAL E 673
LEU E 753
 None
 0.84A 1fm6A-2vsxE:
undetectable		 1fm6A-2vsxE:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 652
ALA E 656
LEU E 614
VAL E 673
LEU E 753
 None
 0.86A 1fm9A-2vsxE:
undetectable		 1fm9A-2vsxE:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 652
ALA E 656
LEU E 614
VAL E 673
LEU E 753
 None
 0.83A 1k74A-2vsxE:
undetectable		 1k74A-2vsxE:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 652
ALA E 656
LEU E 614
VAL E 673
LEU E 753
 None
 1.03A 1xdkE-2vsxE:
undetectable		 1xdkE-2vsxE:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 652
ALA E 656
LEU E 614
VAL E 673
LEU E 753
 None
 0.93A 1xiuA-2vsxE:
undetectable		 1xiuA-2vsxE:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 652
ALA E 656
LEU E 614
VAL E 673
LEU E 753
 None
 0.92A 1xlsA-2vsxE:
undetectable		 1xlsA-2vsxE:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 652
ALA E 656
LEU E 614
VAL E 673
LEU E 753
 None
 0.92A 1xlsB-2vsxE:
undetectable		 1xlsB-2vsxE:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 652
ALA E 656
LEU E 614
VAL E 673
LEU E 753
 None
 0.91A 1xlsC-2vsxE:
undetectable		 1xlsC-2vsxE:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 652
ALA E 656
LEU E 614
VAL E 673
LEU E 753
 None
 0.92A 1xlsD-2vsxE:
undetectable		 1xlsD-2vsxE:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		4 / 5 LEU E 617
ILE E 629
LEU E 630
SER E 627
 None
 0.99A 2byoA-2vsxE:
undetectable		 2byoA-2vsxE:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		4 / 4 ARG E 847
GLY E 795
GLU E 799
SER E 786
 None
 1.33A 2xctS-2vsxE:
undetectable
2xctU-2vsxE:
undetectable		 2xctS-2vsxE:
17.81
2xctU-2vsxE:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		4 / 8 VAL E 700
GLY E 761
THR E 760
PHE E 798
 None
 0.68A 3aruA-2vsxE:
undetectable		 3aruA-2vsxE:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		3 / 3 CYH E 703
HIS E 704
PHE E 707
 None
 1.04A 3cr4X-2vsxE:
undetectable		 3cr4X-2vsxE:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 652
ALA E 656
LEU E 614
VAL E 673
LEU E 753
 None
 0.97A 3oapA-2vsxE:
undetectable		 3oapA-2vsxE:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		5 / 11 ILE E 652
ALA E 656
LEU E 614
VAL E 673
LEU E 753
 None
 0.99A 4nqaA-2vsxE:
undetectable		 4nqaA-2vsxE:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		4 / 7 SER E 786
ARG E 847
GLY E 795
GLU E 799
 None
 0.85A 5btaA-2vsxE:
undetectable
5btaC-2vsxE:
undetectable
5btaD-2vsxE:
undetectable		 5btaA-2vsxE:
20.43
5btaC-2vsxE:
20.43
5btaD-2vsxE:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		4 / 6 SER E 786
ARG E 847
GLY E 795
GLU E 799
 None
 0.86A 5btaA-2vsxE:
undetectable
5btaB-2vsxE:
undetectable
5btaC-2vsxE:
undetectable		 5btaA-2vsxE:
20.43
5btaB-2vsxE:
24.10
5btaC-2vsxE:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		4 / 6 SER E 786
ARG E 847
GLY E 795
GLU E 799
 None
 0.89A 5btcA-2vsxE:
undetectable
5btcC-2vsxE:
undetectable
5btcD-2vsxE:
undetectable		 5btcA-2vsxE:
20.43
5btcC-2vsxE:
20.43
5btcD-2vsxE:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		4 / 6 SER E 786
ARG E 847
GLY E 795
GLU E 799
 None
 0.89A 5btcA-2vsxE:
undetectable
5btcB-2vsxE:
1.8
5btcC-2vsxE:
undetectable		 5btcA-2vsxE:
20.43
5btcB-2vsxE:
24.10
5btcC-2vsxE:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		4 / 7 SER E 786
ARG E 847
GLY E 795
GLU E 799
 None
 0.93A 5btfA-2vsxE:
undetectable
5btfB-2vsxE:
undetectable
5btfC-2vsxE:
undetectable		 5btfA-2vsxE:
20.43
5btfB-2vsxE:
24.10
5btfC-2vsxE:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		4 / 6 SER E 780
GLU E 781
GLY E 710
GLY E 743
 None
 0.91A 5cdnR-2vsxE:
undetectable
5cdnS-2vsxE:
undetectable		 5cdnR-2vsxE:
21.35
5cdnS-2vsxE:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		4 / 5 SER E 786
ARG E 847
GLY E 795
GLU E 799
 None
 1.04A 5cdqA-2vsxE:
undetectable
5cdqB-2vsxE:
undetectable
5cdqC-2vsxE:
undetectable		 5cdqA-2vsxE:
21.35
5cdqB-2vsxE:
19.18
5cdqC-2vsxE:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		4 / 5 SER E 786
ARG E 847
GLY E 795
GLU E 799
 None
 1.04A 5cdqR-2vsxE:
undetectable
5cdqS-2vsxE:
undetectable
5cdqT-2vsxE:
undetectable		 5cdqR-2vsxE:
21.35
5cdqS-2vsxE:
19.18
5cdqT-2vsxE:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 652
ALA E 656
LEU E 614
VAL E 673
LEU E 753
 None
 0.96A 5uanA-2vsxE:
undetectable		 5uanA-2vsxE:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 652
ALA E 656
LEU E 614
VAL E 673
LEU E 753
 None
 0.96A 5z12C-2vsxE:
undetectable		 5z12C-2vsxE:
15.85