SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vt1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2vt1 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
(Shigella
flexneri;
Shigella
flexneri) 		5 / 12 ILE B 277
LEU B 306
ILE B 332
LEU A 253
THR B 313
 None
 1.12A 1dyiA-2vt1B:
undetectable		 1dyiA-2vt1B:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 2vt1 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
(Shigella
flexneri;
Shigella
flexneri) 		5 / 12 ILE B 277
LEU B 306
ILE B 332
LEU A 253
THR B 313
 None
 1.08A 1dyiB-2vt1B:
undetectable		 1dyiB-2vt1B:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 2vt1 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
(Shigella
flexneri;
Shigella
flexneri) 		5 / 12 ILE B 277
LEU B 306
ILE B 332
LEU A 253
THR B 313
 None
 1.00A 1rd7B-2vt1B:
undetectable		 1rd7B-2vt1B:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2vt1 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
(Shigella
flexneri;
Shigella
flexneri) 		5 / 12 ILE B 277
LEU B 306
ILE B 332
LEU A 253
THR B 313
 None
 0.97A 1rx2A-2vt1B:
undetectable		 1rx2A-2vt1B:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2vt1 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
(Shigella
flexneri;
Shigella
flexneri) 		5 / 12 ILE B 277
LEU B 306
ILE B 332
LEU A 253
THR B 313
 None
 1.00A 1rx8A-2vt1B:
undetectable		 1rx8A-2vt1B:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2vt1 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
(Shigella
flexneri) 		3 / 3 ARG B 290
SER B 318
TYR B 317
 None
 0.75A 1x70A-2vt1B:
undetectable		 1x70A-2vt1B:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 2vt1 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
(Shigella
flexneri;
Shigella
flexneri) 		5 / 12 ILE B 277
LEU B 306
ILE B 332
LEU A 253
THR B 313
 None
 0.94A 2d0kA-2vt1B:
undetectable		 2d0kA-2vt1B:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2vt1 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
(Shigella
flexneri) 		4 / 7 VAL B 320
ILE B 277
ILE B 263
THR B 313
 None
 0.84A 3deuA-2vt1B:
undetectable		 3deuA-2vt1B:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 2vt1 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
(Shigella
flexneri) 		5 / 9 LEU B 310
GLY B 264
VAL B 320
VAL B 328
LEU B 329
 None
 1.16A 4qd3A-2vt1B:
undetectable		 4qd3A-2vt1B:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2vt1 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
(Shigella
flexneri;
Shigella
flexneri) 		5 / 12 ILE B 277
LEU B 306
ILE B 332
LEU A 253
THR B 313
 None
 1.13A 4qlgA-2vt1B:
undetectable		 4qlgA-2vt1B:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2vt1 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
(Shigella
flexneri;
Shigella
flexneri) 		5 / 12 ILE B 277
LEU B 306
ILE B 332
LEU A 253
THR B 313
 None
 1.07A 4x5fA-2vt1B:
undetectable		 4x5fA-2vt1B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2vt1 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
(Shigella
flexneri;
Shigella
flexneri) 		5 / 12 ILE B 277
LEU B 306
ILE B 332
LEU A 253
THR B 313
 None
 1.05A 4x5fB-2vt1B:
undetectable		 4x5fB-2vt1B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2vt1 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
(Shigella
flexneri;
Shigella
flexneri) 		5 / 12 ILE B 277
LEU B 306
ILE B 332
LEU A 253
THR B 313
 None
 1.10A 4x5gA-2vt1B:
undetectable		 4x5gA-2vt1B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 2vt1 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
(Shigella
flexneri) 		5 / 12 ASP B 321
GLU B 327
VAL B 328
LEU B 331
ILE B 332
 None
 0.99A 6ectA-2vt1B:
undetectable		 6ectA-2vt1B:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 2vt1 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
(Shigella
flexneri) 		5 / 12 ASP B 321
GLU B 327
VAL B 328
LEU B 331
ILE B 332
 None
 1.00A 6ecxA-2vt1B:
undetectable		 6ecxA-2vt1B:
16.14