SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vt2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2vt2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX
(Bacillus
subtilis) 		4 / 7 LEU A  90
ALA A 116
VAL A 133
VAL A 128
 None
 0.74A 1epbA-2vt2A:
undetectable		 1epbA-2vt2A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 2vt2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX
(Bacillus
subtilis) 		5 / 10 GLU A 140
LEU A 168
ARG A 164
ILE A 187
HIS A 186
 None
 1.42A 1qkuA-2vt2A:
undetectable		 1qkuA-2vt2A:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 2vt2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX
(Bacillus
subtilis) 		5 / 10 GLU A 140
LEU A 168
ARG A 164
ILE A 187
HIS A 186
 None
 1.42A 1qkuB-2vt2A:
undetectable		 1qkuB-2vt2A:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 2vt2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX
(Bacillus
subtilis) 		5 / 10 GLU A 140
LEU A 168
ARG A 164
ILE A 187
HIS A 186
 None
 1.42A 1qkuC-2vt2A:
undetectable		 1qkuC-2vt2A:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 2vt2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX
(Bacillus
subtilis) 		4 / 4 SER A 114
ILE A 113
VAL A 148
THR A 162
 None
 1.24A 1u70A-2vt2A:
2.2		 1u70A-2vt2A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 2vt2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX
(Bacillus
subtilis) 		4 / 8 HIS A 142
ILE A 170
MET A 115
GLU A 140
 None
 0.93A 2x0pA-2vt2A:
undetectable		 2x0pA-2vt2A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 2vt2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX
(Bacillus
subtilis) 		3 / 3 GLU A 197
HIS A 191
HIS A 190
 None
 0.82A 3co4A-2vt2A:
undetectable		 3co4A-2vt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 2vt2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX
(Bacillus
subtilis) 		5 / 12 LEU A 165
ASP A 145
ILE A 113
ILE A 173
ILE A 170
 None
 0.82A 3s54B-2vt2A:
undetectable		 3s54B-2vt2A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2vt2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX
(Bacillus
subtilis) 		5 / 12 GLY A  94
ASP A 118
ILE A 119
ASN A 120
PRO A 154
 NAD  A1210 (-3.3A)
NAD  A1210 (-2.8A)
NAD  A1210 (-4.0A)
None
NAD  A1210 (-4.1A)
 0.94A 4rtsA-2vt2A:
undetectable		 4rtsA-2vt2A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 2vt2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX
(Bacillus
subtilis) 		5 / 12 ILE A 161
ILE A  91
ASP A 118
ILE A 119
ASN A 120
 None
None
NAD  A1210 (-2.8A)
NAD  A1210 (-4.0A)
None
 0.93A 5uvmB-2vt2A:
undetectable		 5uvmB-2vt2A:
22.27