SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vt8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 2vt8 PROTEASOME INHIBITOR
PI31 SUBUNIT
(Homo
sapiens) 		4 / 5 ALA A  14
ILE A  15
ASN A  59
ASP A  20
 None
None
None
CSO  A  17 ( 3.6A)
 0.96A 2h4jA-2vt8A:
undetectable		 2h4jA-2vt8A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2vt8 PROTEASOME INHIBITOR
PI31 SUBUNIT
(Homo
sapiens) 		3 / 3 HIS A  33
ILE A 142
LEU A  78
 None
 0.72A 2kceA-2vt8A:
undetectable		 2kceA-2vt8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 2vt8 PROTEASOME INHIBITOR
PI31 SUBUNIT
(Homo
sapiens) 		4 / 7 ILE A  15
LEU A   7
ASN A  59
ASP A  20
 None
None
None
CSO  A  17 ( 3.6A)
 0.87A 4rmjA-2vt8A:
undetectable		 4rmjA-2vt8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vt8 PROTEASOME INHIBITOR
PI31 SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 106
ARG A 133
ILE A 134
GLY A 137
LEU A  78
 None
 0.81A 5ycnA-2vt8A:
undetectable		 5ycnA-2vt8A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vt8 PROTEASOME INHIBITOR
PI31 SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 106
ARG A 133
ILE A 134
GLY A 137
VAL A  80
 None
 0.69A 5ycnA-2vt8A:
undetectable		 5ycnA-2vt8A:
19.23