SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vtc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 2vtc CEL61B
(Trichoderma
reesei) 		3 / 3 ALA A 226
VAL A 116
TRP A 228
 None
 0.92A 1av2A-2vtcA:
undetectable
1av2B-2vtcA:
undetectable		 1av2A-2vtcA:
4.84
1av2B-2vtcA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 2vtc CEL61B
(Trichoderma
reesei) 		3 / 3 TRP A 228
ALA A 226
VAL A 116
 None
 0.80A 1av2C-2vtcA:
undetectable
1av2D-2vtcA:
undetectable		 1av2C-2vtcA:
4.84
1av2D-2vtcA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2vtc CEL61B
(Trichoderma
reesei) 		4 / 7 GLY A  92
PRO A  93
ILE A 222
GLY A 122
 None
 0.84A 1usqF-2vtcA:
undetectable		 1usqF-2vtcA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 2vtc CEL61B
(Trichoderma
reesei) 		3 / 3 ALA A 226
VAL A 116
TRP A 228
 None
 0.92A 1w5uA-2vtcA:
undetectable
1w5uB-2vtcA:
undetectable		 1w5uA-2vtcA:
4.84
1w5uB-2vtcA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 2vtc CEL61B
(Trichoderma
reesei) 		3 / 3 TRP A 228
ALA A 226
VAL A 116
 None
 0.91A 2izqC-2vtcA:
undetectable
2izqD-2vtcA:
undetectable		 2izqC-2vtcA:
4.84
2izqD-2vtcA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2vtc CEL61B
(Trichoderma
reesei) 		4 / 6 GLY A  92
PRO A  93
ILE A 222
GLY A 122
 None
 0.86A 2jklB-2vtcA:
undetectable		 2jklB-2vtcA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 2vtc CEL61B
(Trichoderma
reesei) 		3 / 3 ARG A 114
GLN A 200
PRO A 197
 None
 0.99A 2qhfA-2vtcA:
undetectable		 2qhfA-2vtcA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2vtc CEL61B
(Trichoderma
reesei) 		4 / 7 ILE A 217
SER A 168
TYR A  91
TYR A 214
 None
 1.33A 2xz5D-2vtcA:
undetectable
2xz5E-2vtcA:
undetectable		 2xz5D-2vtcA:
17.97
2xz5E-2vtcA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2vtc CEL61B
(Trichoderma
reesei) 		5 / 12 LEU A 192
LEU A 150
VAL A 184
ILE A 118
PHE A 157
 None
 1.04A 3fl9B-2vtcA:
undetectable		 3fl9B-2vtcA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2vtc CEL61B
(Trichoderma
reesei) 		5 / 12 LEU A 192
LEU A 150
VAL A 184
ILE A 118
PHE A 157
 None
 1.08A 3fl9G-2vtcA:
undetectable		 3fl9G-2vtcA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 2vtc CEL61B
(Trichoderma
reesei) 		4 / 7 GLN A 174
PRO A 177
GLN A 178
GLU A 160
 NI  A1231 ( 4.7A)
None
None
None
 1.09A 3l2vA-2vtcA:
undetectable		 3l2vA-2vtcA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 2vtc CEL61B
(Trichoderma
reesei) 		3 / 3 TRP A 228
ALA A 226
VAL A 116
 None
 0.85A 3l8lA-2vtcA:
undetectable
3l8lB-2vtcA:
undetectable		 3l8lA-2vtcA:
4.84
3l8lB-2vtcA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 2vtc CEL61B
(Trichoderma
reesei) 		3 / 3 TRP A 228
ALA A 226
VAL A 116
 None
 0.90A 3l8lC-2vtcA:
undetectable
3l8lD-2vtcA:
undetectable		 3l8lC-2vtcA:
4.84
3l8lD-2vtcA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 2vtc CEL61B
(Trichoderma
reesei) 		4 / 5 HIS A   1
HIS A  89
GLN A 174
TYR A 176
 NI  A1231 (-3.2A)
NI  A1231 (-3.2A)
NI  A1231 ( 4.7A)
NI  A1231 (-4.7A)
 0.81A 4gboA-2vtcA:
8.2		 4gboA-2vtcA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 2vtc CEL61B
(Trichoderma
reesei) 		4 / 5 HIS A   1
HIS A  89
GLN A 174
TYR A 176
 NI  A1231 (-3.2A)
NI  A1231 (-3.2A)
NI  A1231 ( 4.7A)
NI  A1231 (-4.7A)
 1.00A 4gboB-2vtcA:
8.5		 4gboB-2vtcA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 2vtc CEL61B
(Trichoderma
reesei) 		4 / 8 ILE A 146
ILE A   9
ALA A  70
VAL A  98
 None
 0.65A 4jltA-2vtcA:
undetectable		 4jltA-2vtcA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2vtc CEL61B
(Trichoderma
reesei) 		5 / 12 ALA A 167
GLY A 172
GLY A 208
ASN A 212
PHE A 211
 None
 1.20A 4obwA-2vtcA:
undetectable		 4obwA-2vtcA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 2vtc CEL61B
(Trichoderma
reesei) 		3 / 3 PRO A 152
ILE A  68
SER A 187
 None
 0.80A 5fsaA-2vtcA:
undetectable		 5fsaA-2vtcA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 2vtc CEL61B
(Trichoderma
reesei) 		5 / 12 PHE A 211
TYR A 214
ILE A 123
GLY A  92
HIS A   1
 None
None
None
None
NI  A1231 (-3.2A)
 1.16A 5fsaB-2vtcA:
undetectable		 5fsaB-2vtcA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 2vtc CEL61B
(Trichoderma
reesei) 		4 / 5 HIS A   1
HIS A  89
GLN A 174
TYR A 176
 NI  A1231 (-3.2A)
NI  A1231 (-3.2A)
NI  A1231 ( 4.7A)
NI  A1231 (-4.7A)
 0.78A 5uizA-2vtcA:
8.5		 5uizA-2vtcA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_B_CUB301_0
(AA10A)		 2vtc CEL61B
(Trichoderma
reesei) 		4 / 4 HIS A   1
HIS A  89
GLN A 174
TYR A 176
 NI  A1231 (-3.2A)
NI  A1231 (-3.2A)
NI  A1231 ( 4.7A)
NI  A1231 (-4.7A)
 0.99A 5uizB-2vtcA:
8.6		 5uizB-2vtcA:
20.44