SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vtx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2B9E_A_SAMA1201_0 (NOL1/NOP2/SUN DOMAIN FAMILY, MEMBER 5 ISOFORM 2)	2vtx	NPM-A PROTEIN (Xenopus laevis)	5 / 12	CYH A 51 PRO A 110 GLY A 109 ASN A 24 ASP A 54	None	1.17A	2b9eA-2vtxA: undetectable	2b9eA-2vtxA: 16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_C_KLNC1498_1 (CYTOCHROME P450 3A4)	2vtx	NPM-A PROTEIN (Xenopus laevis)	5 / 12	LEU A 111 LEU A 23 ILE A 62 ALA A 106 GLU A 73	None	1.23A	2v0mC-2vtxA: undetectable	2v0mC-2vtxA: 13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZIF_B_SAMB298_1 (PUTATIVE MODIFICATION METHYLASE)	2vtx	NPM-A PROTEIN (Xenopus laevis)	3 / 3	ASP A 67 THR A 80 GLU A 64	None	0.75A	2zifB-2vtxA: undetectable	2zifB-2vtxA: 17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BMV_C_VLBC507_2 (TUBULIN ALPHA-1B CHAIN)	2vtx	NPM-A PROTEIN (Xenopus laevis)	4 / 7	VAL A 50 ILE A 113 PHE A 102 VAL A 63	None	0.71A	5bmvC-2vtxA: undetectable	5bmvC-2vtxA: 14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UC3_B_486B801_1 (GLUCOCORTICOID RECEPTOR)	2vtx	NPM-A PROTEIN (Xenopus laevis)	5 / 12	MET A 91 LEU A 47 GLY A 115 LEU A 111 CYH A 51	None	1.25A	5uc3B-2vtxA: undetectable	5uc3B-2vtxA: 18.03

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2B9E_A_SAMA1201_0","NOL1\/NOP2\/SUN DOMAIN FAMILY, MEMBER 5 ISOFORM 2","2vtx","NPM-A PROTEIN","Xenopus laevis",5,"CYH A  51;PRO A 110;GLY A 109;ASN A  24;ASP A  54","None","1.17A","2b9eA-2vtxA:undetectable","2b9eA-2vtxA:16.50"],["2V0M_C_KLNC1498_1","CYTOCHROME P450 3A4","2vtx","NPM-A PROTEIN","Xenopus laevis",5,"LEU A 111;LEU A  23;ILE A  62;ALA A 106;GLU A  73","None","1.23A","2v0mC-2vtxA:undetectable","2v0mC-2vtxA:13.61"],["2ZIF_B_SAMB298_1","PUTATIVE MODIFICATION METHYLASE","2vtx","NPM-A PROTEIN","Xenopus laevis",3,"ASP A  67;THR A  80;GLU A  64","None","0.75A","2zifB-2vtxA:undetectable","2zifB-2vtxA:17.85"],["5BMV_C_VLBC507_2","TUBULIN ALPHA-1B CHAIN","2vtx","NPM-A PROTEIN","Xenopus laevis",4,"VAL A  50;ILE A 113;PHE A 102;VAL A  63","None","0.71A","5bmvC-2vtxA:undetectable","5bmvC-2vtxA:14.41"],["5UC3_B_486B801_1","GLUCOCORTICOID RECEPTOR","2vtx","NPM-A PROTEIN","Xenopus laevis",5,"MET A  91;LEU A  47;GLY A 115;LEU A 111;CYH A  51","None","1.25A","5uc3B-2vtxA:undetectable","5uc3B-2vtxA:18.03"]]