SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vug'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 2vug PAB1020
(Pyrococcus
abyssi) 		5 / 12 PHE A  45
GLY A 117
GLY A  55
ILE A  65
THR A 114
 None
 1.05A 1nv8B-2vugA:
undetectable		 1nv8B-2vugA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 2vug PAB1020
(Pyrococcus
abyssi) 		5 / 5 LEU A  77
ILE A 218
LEU A 221
SER A 222
ARG A 226
 None
 1.44A 2byoA-2vugA:
undetectable		 2byoA-2vugA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 2vug PAB1020
(Pyrococcus
abyssi) 		4 / 5 TYR A 195
ILE A 191
LEU A 171
LEU A 144
 None
 1.16A 2zb7A-2vugA:
undetectable		 2zb7A-2vugA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 2vug PAB1020
(Pyrococcus
abyssi) 		4 / 8 VAL A 157
LEU A 262
GLY A 255
TYR A 266
 None
MPD  A 502 (-4.9A)
None
None
 0.91A 3af0A-2vugA:
undetectable		 3af0A-2vugA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2vug PAB1020
(Pyrococcus
abyssi) 		3 / 3 GLY A 117
GLY A  67
GLY A  55
 None
 0.41A 3bogD-2vugA:
undetectable		 3bogD-2vugA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 2vug PAB1020
(Pyrococcus
abyssi) 		5 / 9 ILE A 191
TYR A 195
ILE A 197
LEU A 144
LEU A 142
 None
 1.36A 3f78A-2vugA:
undetectable		 3f78A-2vugA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 2vug PAB1020
(Pyrococcus
abyssi) 		5 / 9 ILE A 191
TYR A 195
ILE A 197
LEU A 144
LEU A 142
 None
 1.29A 3f78B-2vugA:
undetectable		 3f78B-2vugA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 2vug PAB1020
(Pyrococcus
abyssi) 		3 / 3 LYS A 232
ILE A 197
PHE A 130
 ANP  A 401 (-2.9A)
None
None
 0.93A 3j7zS-2vugA:
undetectable
3j7za-2vugA:
undetectable		 3j7zS-2vugA:
15.92
3j7za-2vugA:
6.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QWU_A_ADNA501_1
(DNA LIGASE)		 2vug PAB1020
(Pyrococcus
abyssi) 		10 / 12 ILE A  71
GLU A  93
LYS A  95
ASN A 100
ARG A 115
GLU A 147
PHE A 172
VAL A 200
LYS A 232
LYS A 241
 ANP  A 401 (-4.3A)
ANP  A 401 (-4.0A)
ANP  A 401 (-3.0A)
ANP  A 401 (-3.8A)
ANP  A 401 (-3.0A)
ANP  A 401 (-2.8A)
ANP  A 401 (-3.5A)
ANP  A 401 (-4.5A)
ANP  A 401 (-2.9A)
ANP  A 401 (-2.8A)
 0.55A 3qwuA-2vugA:
43.4		 3qwuA-2vugA:
36.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QWU_B_ADNB501_1
(DNA LIGASE)		 2vug PAB1020
(Pyrococcus
abyssi) 		9 / 11 ILE A  71
GLU A  93
LYS A  95
ASN A 100
ARG A 115
GLU A 147
PHE A 172
VAL A 200
LYS A 232
 ANP  A 401 (-4.3A)
ANP  A 401 (-4.0A)
ANP  A 401 (-3.0A)
ANP  A 401 (-3.8A)
ANP  A 401 (-3.0A)
ANP  A 401 (-2.8A)
ANP  A 401 (-3.5A)
ANP  A 401 (-4.5A)
ANP  A 401 (-2.9A)
 0.48A 3qwuB-2vugA:
43.6		 3qwuB-2vugA:
36.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2vug PAB1020
(Pyrococcus
abyssi) 		5 / 12 ASN A 248
ILE A 252
ILE A 249
ALA A 275
VAL A 291
 None
 0.92A 3rukB-2vugA:
undetectable		 3rukB-2vugA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2vug PAB1020
(Pyrococcus
abyssi) 		5 / 12 GLY A  55
GLY A 116
LEU A  52
GLY A  31
LEU A  26
 None
 1.01A 4n48A-2vugA:
undetectable		 4n48A-2vugA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2vug PAB1020
(Pyrococcus
abyssi) 		5 / 12 GLY A  55
GLY A 116
LEU A  52
GLY A  31
LEU A  26
 None
 1.02A 4n48B-2vugA:
undetectable		 4n48B-2vugA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2vug PAB1020
(Pyrococcus
abyssi) 		4 / 4 GLY A  80
VAL A 240
PHE A 203
ILE A 229
 None
 0.89A 4xv2B-2vugA:
undetectable		 4xv2B-2vugA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2vug PAB1020
(Pyrococcus
abyssi) 		4 / 5 ALA A 367
TYR A 364
GLY A 228
LEU A 156
 None
 0.98A 5eslA-2vugA:
undetectable		 5eslA-2vugA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2vug PAB1020
(Pyrococcus
abyssi) 		5 / 12 ILE A 218
GLY A 228
TYR A 242
GLU A 287
ILE A 249
 None
 1.29A 5igwA-2vugA:
undetectable		 5igwA-2vugA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2vug PAB1020
(Pyrococcus
abyssi) 		3 / 3 TYR A 155
HIS A 336
MET A 333
 None
 1.14A 6af6A-2vugA:
undetectable		 6af6A-2vugA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2vug PAB1020
(Pyrococcus
abyssi) 		4 / 8 HIS A 317
GLU A 314
ASP A 309
GLU A 305
 None
 1.26A 6mn4B-2vugA:
undetectable		 6mn4B-2vugA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2vug PAB1020
(Pyrococcus
abyssi) 		4 / 7 HIS A 317
GLU A 314
ASP A 309
GLU A 305
 None
 1.40A 6mn4F-2vugA:
undetectable		 6mn4F-2vugA:
20.31