SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vut'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
(Aspergillus
nidulans) 		5 / 12 PHE A 181
PHE A 165
TYR A 153
LEU A 218
GLN A  17
 None
None
NAD  A1353 (-3.5A)
None
NAD  A1353 (-4.4A)
 1.09A 1brpA-2vutA:
undetectable		 1brpA-2vutA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
(Aspergillus
nidulans) 		4 / 8 TYR A 258
GLN A  84
GLN A  17
SER A  83
 None
NAD  A1353 (-3.8A)
NAD  A1353 (-4.4A)
None
 1.14A 2xz5B-2vutA:
undetectable
2xz5E-2vutA:
undetectable		 2xz5B-2vutA:
19.66
2xz5E-2vutA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
(Aspergillus
nidulans) 		4 / 8 GLN A  84
GLN A  17
SER A  83
TYR A 258
 NAD  A1353 (-3.8A)
NAD  A1353 (-4.4A)
None
None
 1.12A 2xz5C-2vutA:
undetectable
2xz5D-2vutA:
undetectable		 2xz5C-2vutA:
19.66
2xz5D-2vutA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
(Aspergillus
nidulans) 		3 / 3 PRO A 163
GLU A 260
TYR A 258
 None
 0.81A 2zmbA-2vutA:
1.1		 2zmbA-2vutA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
(Aspergillus
nidulans) 		4 / 7 VAL A 268
VAL A 267
GLY A 270
PRO A 180
 None
 0.95A 3bjwC-2vutA:
undetectable		 3bjwC-2vutA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
(Aspergillus
nidulans) 		4 / 7 PHE A 181
SER A 224
VAL A 228
TRP A 189
 None
 1.26A 3dqtA-2vutA:
undetectable
3dqtB-2vutA:
undetectable		 3dqtA-2vutA:
22.59
3dqtB-2vutA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
(Aspergillus
nidulans) 		3 / 3 VAL A 248
LYS A 247
HIS A 116
 None
 0.89A 3elzA-2vutA:
undetectable		 3elzA-2vutA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
NITROGEN REGULATORY
PROTEIN AREA
(Aspergillus
nidulans) 		3 / 3 GLU A 333
GLU A 337
TRP I 684
 None
 1.08A 3hrdA-2vutA:
undetectable
3hrdE-2vutA:
undetectable
3hrdF-2vutA:
undetectable		 3hrdA-2vutA:
20.71
3hrdE-2vutA:
20.71
3hrdF-2vutA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
(Aspergillus
nidulans) 		3 / 3 PRO A  59
LEU A  60
GLN A  35
 None
 0.44A 3hznG-2vutA:
undetectable
3hznH-2vutA:
undetectable		 3hznG-2vutA:
22.12
3hznH-2vutA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
(Aspergillus
nidulans) 		4 / 8 PHE A 181
SER A 224
VAL A 228
TRP A 189
 None
 1.17A 3nlrA-2vutA:
undetectable
3nlrB-2vutA:
undetectable		 3nlrA-2vutA:
22.10
3nlrB-2vutA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
(Aspergillus
nidulans) 		4 / 7 ALA A 150
SER A 111
VAL A 148
LEU A 218
 NAD  A1353 (-3.7A)
None
None
None
 0.77A 3o14A-2vutA:
undetectable		 3o14A-2vutA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
(Aspergillus
nidulans) 		5 / 12 ARG A  23
GLY A 197
GLU A 193
ALA A 192
TYR A 153
 None
None
None
None
NAD  A1353 (-3.5A)
 1.41A 3t7sC-2vutA:
5.0		 3t7sC-2vutA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
(Aspergillus
nidulans) 		4 / 7 PHE A 181
SER A 224
VAL A 228
TRP A 189
 None
 1.24A 4k5jA-2vutA:
undetectable
4k5jB-2vutA:
undetectable		 4k5jA-2vutA:
22.36
4k5jB-2vutA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
NITROGEN REGULATORY
PROTEIN AREA
(Aspergillus
nidulans;
Aspergillus
nidulans) 		4 / 8 LEU A  47
PRO I 709
VAL A 196
GLY A 197
 None
 0.91A 4klrB-2vutA:
2.7		 4klrB-2vutA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
NITROGEN REGULATORY
PROTEIN AREA
(Aspergillus
nidulans) 		5 / 12 THR I 681
THR I 680
ARG A 322
SER A 326
GLY A 327
 None
 1.27A 5lf3b-2vutI:
undetectable		 5lf3b-2vutI:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
NITROGEN REGULATORY
PROTEIN AREA
(Aspergillus
nidulans) 		5 / 12 THR I 681
THR I 680
ARG A 322
SER A 326
GLY A 327
 None
 1.26A 5lf3N-2vutI:
undetectable		 5lf3N-2vutI:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
(Aspergillus
nidulans) 		4 / 8 PHE A 181
THR A 219
ILE A 152
GLY A 151
 None
None
NAD  A1353 (-4.3A)
NAD  A1353 (-4.7A)
 0.93A 5nzxA-2vutA:
undetectable		 5nzxA-2vutA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
(Aspergillus
nidulans) 		4 / 7 PHE A 181
THR A 219
ILE A 152
GLY A 151
 None
None
NAD  A1353 (-4.3A)
NAD  A1353 (-4.7A)
 0.93A 5nzyA-2vutA:
undetectable		 5nzyA-2vutA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
(Aspergillus
nidulans) 		4 / 7 PHE A 181
SER A 224
VAL A 228
TRP A 189
 None
 1.23A 5vvnA-2vutA:
undetectable
5vvnB-2vutA:
undetectable		 5vvnA-2vutA:
22.36
5vvnB-2vutA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
(Aspergillus
nidulans) 		4 / 7 SER A 224
VAL A 228
TRP A 189
PHE A 181
 None
 1.29A 6av6A-2vutA:
undetectable
6av6B-2vutA:
undetectable		 6av6A-2vutA:
13.86
6av6B-2vutA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
(Aspergillus
nidulans) 		4 / 7 PHE A 181
SER A 224
VAL A 228
TRP A 189
 None
 1.23A 6av6C-2vutA:
undetectable
6av6D-2vutA:
undetectable		 6av6C-2vutA:
13.86
6av6D-2vutA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
(Aspergillus
nidulans) 		4 / 7 SER A 224
VAL A 228
TRP A 189
PHE A 181
 None
 1.21A 6av7A-2vutA:
undetectable
6av7B-2vutA:
undetectable		 6av7A-2vutA:
13.86
6av7B-2vutA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
NITROGEN REGULATORY
PROTEIN AREA
(Aspergillus
nidulans;
Aspergillus
nidulans) 		4 / 6 ASP A 195
ARG A 329
GLU A 333
CYH I 673
 None
None
None
ZN  I1713 (-2.4A)
 1.31A 6mn5D-2vutA:
undetectable		 6mn5D-2vutA:
14.12