SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vv8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2vv8 SENSOR PROTEIN FIXL
(Bradyrhizobium
japonicum) 		6 / 12 GLY A 251
GLY A 239
GLY A 217
THR A 250
GLU A 240
ILE A 157
 HEM  A1258 (-3.8A)
None
None
None
None
HEM  A1258 (-3.8A)
 1.21A 2oxtC-2vv8A:
undetectable		 2oxtC-2vv8A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2vv8 SENSOR PROTEIN FIXL
(Bradyrhizobium
japonicum) 		5 / 12 ILE A 216
GLY A 251
GLY A 239
ILE A 159
LEU A 191
 HEM  A1258 (-4.0A)
HEM  A1258 (-3.8A)
None
HEM  A1258 (-4.0A)
HEM  A1258 (-4.2A)
 1.01A 4iv0A-2vv8A:
undetectable		 4iv0A-2vv8A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 2vv8 SENSOR PROTEIN FIXL
(Bradyrhizobium
japonicum) 		5 / 12 ILE A 165
ILE A 204
LEU A 236
VAL A 222
ILE A 157
 None
HEM  A1258 ( 4.6A)
CMO  A1259 ( 3.7A)
HEM  A1258 (-4.2A)
HEM  A1258 (-3.8A)
 0.92A 4km2A-2vv8A:
undetectable		 4km2A-2vv8A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 2vv8 SENSOR PROTEIN FIXL
(Bradyrhizobium
japonicum) 		5 / 12 ILE A 165
ILE A 204
LEU A 236
VAL A 222
ILE A 157
 None
HEM  A1258 ( 4.6A)
CMO  A1259 ( 3.7A)
HEM  A1258 (-4.2A)
HEM  A1258 (-3.8A)
 0.77A 4km2B-2vv8A:
undetectable		 4km2B-2vv8A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2vv8 SENSOR PROTEIN FIXL
(Bradyrhizobium
japonicum) 		5 / 12 ILE A 216
GLY A 251
GLY A 239
ILE A 159
LEU A 191
 HEM  A1258 (-4.0A)
HEM  A1258 (-3.8A)
None
HEM  A1258 (-4.0A)
HEM  A1258 (-4.2A)
 1.09A 4mwzA-2vv8A:
undetectable		 4mwzA-2vv8A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 2vv8 SENSOR PROTEIN FIXL
(Bradyrhizobium
japonicum) 		5 / 12 GLY A 251
GLY A 239
GLY A 217
THR A 250
GLU A 240
 HEM  A1258 (-3.8A)
None
None
None
None
 1.04A 5ehiC-2vv8A:
undetectable		 5ehiC-2vv8A:
18.29