SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vvg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2vvg KINESIN-2
(Giardia
intestinalis) 		4 / 7 TYR A 287
THR A  92
THR A 306
VAL A 274
 None
 1.18A 1tv8A-2vvgA:
undetectable		 1tv8A-2vvgA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 2vvg KINESIN-2
(Giardia
intestinalis) 		4 / 5 LEU A 146
LEU A 144
LEU A 161
LEU A 163
 None
 0.96A 2ab2B-2vvgA:
undetectable		 2ab2B-2vvgA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 2vvg KINESIN-2
(Giardia
intestinalis) 		5 / 12 LEU A 307
ASP A 241
ILE A 117
GLY A 115
ILE A  93
 None
MG  A1352 ( 4.1A)
None
None
None
 0.91A 2avvE-2vvgA:
undetectable		 2avvE-2vvgA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2vvg KINESIN-2
(Giardia
intestinalis) 		4 / 8 TYR A 287
THR A  92
THR A 306
VAL A 274
 None
 1.19A 2fb2A-2vvgA:
undetectable		 2fb2A-2vvgA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2vvg KINESIN-2
(Giardia
intestinalis) 		4 / 7 TYR A 287
THR A  92
THR A 306
VAL A 274
 None
 1.20A 2fb2B-2vvgA:
undetectable		 2fb2B-2vvgA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2vvg KINESIN-2
(Giardia
intestinalis) 		3 / 3 ASP A 289
ARG A 294
ARG A 288
 None
 1.00A 2j9dA-2vvgA:
undetectable
2j9dC-2vvgA:
undetectable		 2j9dA-2vvgA:
20.91
2j9dC-2vvgA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 2vvg KINESIN-2
(Giardia
intestinalis) 		5 / 12 LEU A 307
ASP A 241
ILE A 117
GLY A 115
ILE A  93
 None
MG  A1352 ( 4.1A)
None
None
None
 0.79A 2o4kA-2vvgA:
undetectable		 2o4kA-2vvgA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 2vvg KINESIN-2
(Giardia
intestinalis) 		5 / 12 LEU A 307
ASP A 241
ILE A 117
GLY A 115
ILE A  93
 None
MG  A1352 ( 4.1A)
None
None
None
 0.88A 2o4lB-2vvgA:
undetectable		 2o4lB-2vvgA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2vvg KINESIN-2
(Giardia
intestinalis) 		3 / 3 ILE A  93
ILE A   9
LEU A 292
 None
 0.54A 2prgA-2vvgA:
undetectable		 2prgA-2vvgA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2vvg KINESIN-2
(Giardia
intestinalis) 		5 / 12 LEU A 307
ASP A 241
ILE A 117
GLY A 115
ILE A  93
 None
MG  A1352 ( 4.1A)
None
None
None
 0.82A 2q63A-2vvgA:
undetectable		 2q63A-2vvgA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2vvg KINESIN-2
(Giardia
intestinalis) 		5 / 12 LEU A 307
ASP A 241
ILE A 117
GLY A 115
ILE A  93
 None
MG  A1352 ( 4.1A)
None
None
None
 0.80A 2qakA-2vvgA:
undetectable		 2qakA-2vvgA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vvg KINESIN-2
(Giardia
intestinalis) 		5 / 10 GLU A  19
ARG A  13
ILE A 312
ARG A  29
ILE A  27
 None
 1.28A 3adsA-2vvgA:
undetectable		 3adsA-2vvgA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 2vvg KINESIN-2
(Giardia
intestinalis) 		5 / 12 LEU A  86
ALA A  84
ILE A  82
SER A  91
LEU A 237
 None
 1.24A 3gyqA-2vvgA:
undetectable
3gyqB-2vvgA:
undetectable		 3gyqA-2vvgA:
21.37
3gyqB-2vvgA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 2vvg KINESIN-2
(Giardia
intestinalis) 		5 / 12 LEU A 307
ASP A 241
ILE A 117
GLY A 115
ILE A  93
 None
MG  A1352 ( 4.1A)
None
None
None
 0.82A 3jw2B-2vvgA:
undetectable		 3jw2B-2vvgA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 2vvg KINESIN-2
(Giardia
intestinalis) 		5 / 11 LEU A 307
ASP A 241
ILE A 117
GLY A 115
ILE A  93
 None
MG  A1352 ( 4.1A)
None
None
None
 0.80A 3oxxD-2vvgA:
undetectable		 3oxxD-2vvgA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2vvg KINESIN-2
(Giardia
intestinalis) 		3 / 3 GLY A 100
GLY A 102
THR A 104
 ADP  A1351 (-3.5A)
ADP  A1351 (-3.0A)
MG  A1352 ( 3.0A)
 0.43A 3si7B-2vvgA:
undetectable		 3si7B-2vvgA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 2vvg KINESIN-2
(Giardia
intestinalis) 		4 / 5 THR A 306
ILE A   6
PHE A  94
LEU A 300
 None
 1.15A 3tf1A-2vvgA:
0.4		 3tf1A-2vvgA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 2vvg KINESIN-2
(Giardia
intestinalis) 		5 / 9 ILE A  82
LEU A 237
VAL A 218
VAL A 240
LEU A 239
 None
 1.16A 4g1bC-2vvgA:
undetectable		 4g1bC-2vvgA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 2vvg KINESIN-2
(Giardia
intestinalis) 		5 / 12 ALA A 101
TYR A 328
TYR A  96
LEU A 268
LEU A 271
 ADP  A1351 (-4.3A)
None
None
None
None
 1.15A 4l9qB-2vvgA:
undetectable		 4l9qB-2vvgA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2vvg KINESIN-2
(Giardia
intestinalis) 		5 / 12 LEU A 326
VAL A  39
ILE A  28
ILE A 312
ALA A 101
 None
None
None
None
ADP  A1351 (-4.3A)
 1.09A 4ltwA-2vvgA:
undetectable		 4ltwA-2vvgA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2vvg KINESIN-2
(Giardia
intestinalis) 		5 / 12 LEU A 326
VAL A  39
LEU A  25
ILE A  28
ILE A 312
 None
 0.79A 4ltwA-2vvgA:
undetectable		 4ltwA-2vvgA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2vvg KINESIN-2
(Giardia
intestinalis) 		5 / 12 LEU A 237
HIS A 123
LEU A 124
ALA A 127
SER A 130
 None
 0.87A 5nd3B-2vvgA:
undetectable		 5nd3B-2vvgA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2vvg KINESIN-2
(Giardia
intestinalis) 		5 / 12 LEU A 237
HIS A 123
LEU A 124
ALA A 127
SER A 130
 None
 1.15A 5nd7B-2vvgA:
undetectable		 5nd7B-2vvgA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8A_F_ACTF803_0
(UNCHARACTERIZED
PROTEIN)		 2vvg KINESIN-2
(Giardia
intestinalis) 		4 / 4 MET A 308
TYR A  96
ARG A 331
LEU A 271
 None
 1.12A 6d8aF-2vvgA:
0.0		 6d8aF-2vvgA:
18.62