SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vvq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  96
TRP A  91
ILE A  21
LEU A  17
THR A  95
 None
 1.21A 1jolA-2vvqA:
undetectable		 1jolA-2vvqA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B
(Mycobacterium
tuberculosis) 		4 / 5 PRO A  32
LEU A   8
GLY A   9
LYS A  18
 None
 0.94A 1ya4C-2vvqA:
undetectable		 1ya4C-2vvqA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  13
GLY A  74
GLU A  75
LEU A  68
VAL A  67
 R10  A 200 ( 3.8A)
R10  A 200 (-3.1A)
R10  A 200 (-2.7A)
None
None
 1.18A 2zifA-2vvqA:
undetectable		 2zifA-2vvqA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  65
ILE A  21
VAL A 124
VAL A 128
 None
 0.77A 3fi0I-2vvqA:
undetectable		 3fi0I-2vvqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 100
VAL A 128
TYR A   7
ILE A  66
 None
 1.01A 3remA-2vvqA:
undetectable		 3remA-2vvqA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 100
VAL A 128
TYR A   7
ILE A  66
 None
 1.04A 3remB-2vvqA:
undetectable		 3remB-2vvqA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B
(Mycobacterium
tuberculosis) 		5 / 8 GLY A   9
ALA A  10
ASP A  11
GLY A 109
ILE A 108
 None
None
R10  A 200 (-2.8A)
None
None
 1.37A 3so9A-2vvqA:
undetectable		 3so9A-2vvqA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  11
GLY A  70
TYR A  46
 R10  A 200 (-2.8A)
R10  A 200 (-3.1A)
R10  A 200 (-3.6A)
 0.76A 3w9tC-2vvqA:
undetectable		 3w9tC-2vvqA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  11
GLY A  70
TYR A  46
 R10  A 200 (-2.8A)
R10  A 200 (-3.1A)
R10  A 200 (-3.6A)
 0.76A 3w9tG-2vvqA:
undetectable		 3w9tG-2vvqA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  96
VAL A 124
GLY A 109
GLY A 111
ILE A 110
 None
 1.03A 4q5mA-2vvqA:
undetectable		 4q5mA-2vvqA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B
(Mycobacterium
tuberculosis) 		4 / 6 GLU A  23
GLY A  69
ASP A  11
GLY A 112
 None
R10  A 200 (-3.5A)
R10  A 200 (-2.8A)
None
 0.93A 5cdnR-2vvqA:
undetectable
5cdnS-2vvqA:
2.2		 5cdnR-2vvqA:
15.34
5cdnS-2vvqA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 108
GLY A  72
ILE A  66
LEU A  89
 None
R10  A 200 (-3.4A)
None
None
 0.93A 5dzkd-2vvqA:
undetectable
5dzkk-2vvqA:
undetectable
5dzky-2vvqA:
undetectable		 5dzkd-2vvqA:
24.77
5dzkk-2vvqA:
25.96
5dzky-2vvqA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 140
HIS A 138
ARG A 141
 None
 0.93A 5iaoC-2vvqA:
2.6		 5iaoC-2vvqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 140
HIS A 138
ARG A 141
 None
 0.96A 5iaoF-2vvqA:
2.6		 5iaoF-2vvqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B
(Mycobacterium
tuberculosis) 		4 / 5 PHE A 127
ILE A 108
GLN A 106
ARG A 100
 None
 1.39A 5jm4A-2vvqA:
undetectable		 5jm4A-2vvqA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B
(Mycobacterium
tuberculosis) 		4 / 4 PHE A 127
ILE A 108
GLN A 106
ARG A 100
 None
 1.30A 5jm4B-2vvqA:
0.0		 5jm4B-2vvqA:
19.16