SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vvx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vvx PROTEIN A52
(Vaccinia
virus) 		5 / 10 VAL A 131
ILE A 164
ILE A  83
LEU A 180
ILE A 135
 None
 1.12A 3hbbA-2vvxA:
undetectable		 3hbbA-2vvxA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2vvx PROTEIN A52
(Vaccinia
virus) 		4 / 7 VAL A 144
LEU A 100
LEU A 104
ILE A 119
 None
 0.95A 3u5kB-2vvxA:
undetectable		 3u5kB-2vvxA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2vvx PROTEIN A52
(Vaccinia
virus) 		5 / 11 ILE A  83
ALA A 142
ASP A  87
PHE A  86
ARG A 183
 None
 1.18A 4i1nA-2vvxA:
undetectable		 4i1nA-2vvxA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 2vvx PROTEIN A52
(Vaccinia
virus) 		3 / 3 ARG A 105
GLU A 110
ASN A 114
 None
 0.83A 4imaD-2vvxA:
undetectable		 4imaD-2vvxA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 2vvx PROTEIN A52
(Vaccinia
virus) 		3 / 3 ARG A 105
GLU A 110
ASN A 114
 None
 0.84A 4ip7D-2vvxA:
undetectable		 4ip7D-2vvxA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 2vvx PROTEIN A52
(Vaccinia
virus) 		5 / 12 MET A 137
LEU A 140
LEU A 106
ILE A 119
ILE A 116
 None
 0.94A 4j24A-2vvxA:
undetectable		 4j24A-2vvxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2vvx PROTEIN A52
(Vaccinia
virus) 		5 / 11 TRP A 148
GLY A 139
ILE A  83
GLY A  68
PHE A 115
 None
 1.18A 4qoiA-2vvxA:
undetectable
4qoiB-2vvxA:
undetectable		 4qoiA-2vvxA:
21.03
4qoiB-2vvxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2vvx PROTEIN A52
(Vaccinia
virus) 		5 / 12 ILE A  83
ALA A 142
ASP A  87
PHE A  86
ARG A 183
 None
 1.19A 4rgcA-2vvxA:
undetectable		 4rgcA-2vvxA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2vvx PROTEIN A52
(Vaccinia
virus) 		4 / 8 VAL A 144
LEU A 100
LEU A 104
ILE A 119
 None
 0.84A 5y1yA-2vvxA:
undetectable		 5y1yA-2vvxA:
22.81