SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vw8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		4 / 6 MET A 254
LEU A 290
GLU A 256
LEU A 293
 None
 1.11A 1etb1-2vw8A:
undetectable		 1etb1-2vw8A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  52
VAL A  88
PRO A  79
LEU A  81
PRO A  83
 None
 1.45A 1klmA-2vw8A:
undetectable		 1klmA-2vw8A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_B_RIOB501_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		5 / 9 ASP A  73
GLU A  38
GLY A  40
ASP A 162
THR A  96
 FE2  A 401 ( 2.8A)
None
None
None
None
 1.47A 1m4gB-2vw8A:
2.2		 1m4gB-2vw8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_B_KANB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		5 / 9 ASP A  73
GLU A  38
GLY A  40
ASP A 162
THR A  96
 FE2  A 401 ( 2.8A)
None
None
None
None
 1.45A 1m4iB-2vw8A:
undetectable		 1m4iB-2vw8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		6 / 12 LEU A 208
LEU A 205
LEU A 202
VAL A 194
TYR A 201
ILE A 154
 None
 1.38A 1s9pC-2vw8A:
undetectable		 1s9pC-2vw8A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		3 / 3 PRO A  23
ASP A  44
ASP A  73
 None
None
FE2  A 401 ( 2.8A)
 0.68A 1sqfA-2vw8A:
undetectable		 1sqfA-2vw8A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 154
HIS A 163
VAL A 165
LEU A 174
LEU A 180
 None
 0.88A 2aw1A-2vw8A:
undetectable		 2aw1A-2vw8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 211
PRO A 212
LEU A 214
ARG A 173
 None
 1.41A 2hrcA-2vw8A:
undetectable		 2hrcA-2vw8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  69
ASP A 162
GLY A  39
HIS A 221
ASP A 178
 FE2  A 402 (-3.4A)
None
None
FE2  A 401 ( 3.4A)
FE2  A 401 (-2.5A)
 1.23A 2pgfA-2vw8A:
undetectable		 2pgfA-2vw8A:
18.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		8 / 8 ASP A  73
ASP A 178
GLU A 182
LEU A 193
HIS A 221
SER A 273
LEU A 277
HIS A 282
 FE2  A 401 ( 2.8A)
FE2  A 401 (-2.5A)
None
CAC  A 403 ( 4.5A)
FE2  A 401 ( 3.4A)
None
CAC  A 403 ( 4.7A)
None
 0.42A 2q0iA-2vw8A:
51.9		 2q0iA-2vw8A:
99.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q0J_A_BEZA500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		10 / 10 ASP A  73
HIS A 159
ASP A 178
GLU A 182
LEU A 193
PHE A 195
HIS A 221
SER A 273
LEU A 277
HIS A 282
 FE2  A 401 ( 2.8A)
FE2  A 402 ( 3.3A)
FE2  A 401 (-2.5A)
None
CAC  A 403 ( 4.5A)
CAC  A 403 (-4.8A)
FE2  A 401 ( 3.4A)
None
CAC  A 403 ( 4.7A)
None
 0.18A 2q0jA-2vw8A:
52.3		 2q0jA-2vw8A:
94.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		11 / 11 ASP A  73
HIS A  74
HIS A 159
ASP A 178
GLU A 182
LEU A 193
PHE A 195
HIS A 221
SER A 273
LEU A 277
HIS A 282
 FE2  A 401 ( 2.8A)
FE2  A 401 (-3.3A)
FE2  A 402 ( 3.3A)
FE2  A 401 (-2.5A)
None
CAC  A 403 ( 4.5A)
CAC  A 403 (-4.8A)
FE2  A 401 ( 3.4A)
None
CAC  A 403 ( 4.7A)
None
 0.15A 2q0jB-2vw8A:
52.3		 2q0jB-2vw8A:
94.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		6 / 11 HIS A  69
ASP A 178
GLU A 182
LEU A 193
PHE A 195
HIS A 282
 FE2  A 402 (-3.4A)
FE2  A 401 (-2.5A)
None
CAC  A 403 ( 4.5A)
CAC  A 403 (-4.8A)
None
 1.10A 2q0jB-2vw8A:
52.3		 2q0jB-2vw8A:
94.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 159
HIS A  69
HIS A 163
 FE2  A 402 ( 3.3A)
FE2  A 402 (-3.4A)
None
 0.75A 3ag4A-2vw8A:
undetectable		 3ag4A-2vw8A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		4 / 8 GLY A  76
ASN A 113
PHE A 276
TYR A  72
 None
None
None
CAC  A 403 ( 4.7A)
 0.72A 3ccfA-2vw8A:
undetectable		 3ccfA-2vw8A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 218
PHE A 175
ASP A  13
LEU A  27
HIS A 149
 None
 1.30A 3o1xA-2vw8A:
undetectable		 3o1xA-2vw8A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 218
PHE A 175
ASP A  13
LEU A  27
HIS A 149
 None
 1.29A 3qgzA-2vw8A:
undetectable		 3qgzA-2vw8A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		3 / 3 SER A 273
ASP A 178
ASP A 162
 None
FE2  A 401 (-2.5A)
None
 0.91A 3uj7A-2vw8A:
undetectable		 3uj7A-2vw8A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		5 / 10 HIS A  69
HIS A  71
ASP A  73
HIS A 159
HIS A 221
 FE2  A 402 (-3.4A)
FE2  A 402 ( 3.2A)
FE2  A 401 ( 2.8A)
FE2  A 402 ( 3.3A)
FE2  A 401 ( 3.4A)
 0.81A 4c1dB-2vw8A:
18.0		 4c1dB-2vw8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		5 / 11 HIS A  69
HIS A  71
ASP A  73
HIS A 159
HIS A 221
 FE2  A 402 (-3.4A)
FE2  A 402 ( 3.2A)
FE2  A 401 ( 2.8A)
FE2  A 402 ( 3.3A)
FE2  A 401 ( 3.4A)
 0.88A 4c1fA-2vw8A:
17.9
4c1fB-2vw8A:
18.0		 4c1fA-2vw8A:
21.12
4c1fB-2vw8A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		5 / 9 HIS A  69
HIS A  71
ASP A  73
HIS A 159
HIS A 221
 FE2  A 402 (-3.4A)
FE2  A 402 ( 3.2A)
FE2  A 401 ( 2.8A)
FE2  A 402 ( 3.3A)
FE2  A 401 ( 3.4A)
 0.82A 4c1hA-2vw8A:
19.1		 4c1hA-2vw8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  76
ASP A  73
GLY A  40
HIS A  69
HIS A 221
 None
FE2  A 401 ( 2.8A)
None
FE2  A 402 (-3.4A)
FE2  A 401 ( 3.4A)
 1.12A 4c5nB-2vw8A:
undetectable		 4c5nB-2vw8A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		4 / 8 HIS A  71
ASP A  73
HIS A 159
HIS A 221
 FE2  A 402 ( 3.2A)
FE2  A 401 ( 2.8A)
FE2  A 402 ( 3.3A)
FE2  A 401 ( 3.4A)
 0.85A 4exsB-2vw8A:
5.7		 4exsB-2vw8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		4 / 5 GLY A  40
GLY A  76
ASN A 113
GLU A  38
 None
 1.23A 4fglC-2vw8A:
undetectable		 4fglC-2vw8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 293
MET A 198
ASP A 184
 None
 0.79A 4j7xB-2vw8A:
undetectable		 4j7xB-2vw8A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		3 / 3 TYR A  80
GLN A 121
TRP A  49
 None
 1.13A 4kn2C-2vw8A:
undetectable		 4kn2C-2vw8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		4 / 5 VAL A  90
LEU A  78
ILE A  67
LEU A  66
 None
 0.79A 4mghA-2vw8A:
undetectable		 4mghA-2vw8A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 281
GLY A 279
GLU A 182
ALA A 268
 None
 0.90A 4rjdA-2vw8A:
undetectable
4rjdB-2vw8A:
undetectable		 4rjdA-2vw8A:
13.74
4rjdB-2vw8A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 164
ALA A  92
PHE A 166
 None
 0.94A 4w5nA-2vw8A:
undetectable		 4w5nA-2vw8A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 248
LEU A 244
LEU A 290
GLU A 263
LEU A 265
 None
 1.00A 4wg0B-2vw8A:
undetectable
4wg0C-2vw8A:
undetectable
4wg0D-2vw8A:
undetectable		 4wg0B-2vw8A:
2.98
4wg0C-2vw8A:
2.98
4wg0D-2vw8A:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 248
LEU A 244
LEU A 290
GLU A 263
LEU A 265
 None
 0.99A 4wg0F-2vw8A:
undetectable
4wg0G-2vw8A:
undetectable
4wg0H-2vw8A:
undetectable		 4wg0F-2vw8A:
2.98
4wg0G-2vw8A:
2.98
4wg0H-2vw8A:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  12
ASP A  11
ASP A  13
ILE A 218
 None
 0.91A 4xjeA-2vw8A:
undetectable		 4xjeA-2vw8A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 244
VAL A 189
ASP A 184
 None
 0.64A 4y8wC-2vw8A:
undetectable		 4y8wC-2vw8A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		4 / 7 ILE A  41
LEU A  77
GLY A  39
GLY A  40
 None
 0.80A 5a06A-2vw8A:
undetectable		 5a06A-2vw8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		4 / 7 ILE A  41
LEU A  77
GLY A  39
GLY A  40
 None
 0.81A 5a06B-2vw8A:
undetectable		 5a06B-2vw8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		4 / 7 ILE A  41
LEU A  77
GLY A  39
GLY A  40
 None
 0.81A 5a06C-2vw8A:
undetectable		 5a06C-2vw8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		4 / 7 ILE A  41
LEU A  77
GLY A  39
GLY A  40
 None
 0.82A 5a06E-2vw8A:
undetectable		 5a06E-2vw8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		4 / 7 ILE A  41
LEU A  77
GLY A  39
GLY A  40
 None
 0.79A 5a06F-2vw8A:
undetectable		 5a06F-2vw8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		4 / 8 HIS A  71
ASP A  73
HIS A 159
HIS A 221
 FE2  A 402 ( 3.2A)
FE2  A 401 ( 2.8A)
FE2  A 402 ( 3.3A)
FE2  A 401 ( 3.4A)
 0.86A 5a5zA-2vw8A:
17.4		 5a5zA-2vw8A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		6 / 11 HIS A  69
HIS A  71
ASP A  73
HIS A  74
HIS A 159
HIS A 221
 FE2  A 402 (-3.4A)
FE2  A 402 ( 3.2A)
FE2  A 401 ( 2.8A)
FE2  A 401 (-3.3A)
FE2  A 402 ( 3.3A)
FE2  A 401 ( 3.4A)
 0.41A 5ayaA-2vw8A:
19.0		 5ayaA-2vw8A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  12
ASP A  11
ASP A  13
ILE A 218
 None
 0.96A 5cfsA-2vw8A:
undetectable		 5cfsA-2vw8A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		5 / 12 PRO A  59
LEU A  85
VAL A  24
TRP A  49
LEU A  81
 None
 1.44A 5cymA-2vw8A:
undetectable		 5cymA-2vw8A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		5 / 12 PRO A  59
LEU A  85
VAL A  24
TRP A  49
LEU A  81
 None
 1.44A 5cyqA-2vw8A:
undetectable		 5cyqA-2vw8A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 229
HIS A 159
GLU A 182
PHE A 183
GLY A 222
 None
FE2  A 402 ( 3.3A)
None
None
None
 1.05A 5l6eA-2vw8A:
undetectable		 5l6eA-2vw8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		5 / 10 HIS A  69
HIS A  71
HIS A  74
HIS A 159
ASP A 178
 FE2  A 402 (-3.4A)
FE2  A 402 ( 3.2A)
FE2  A 401 (-3.3A)
FE2  A 402 ( 3.3A)
FE2  A 401 (-2.5A)
 0.36A 5nzwA-2vw8A:
2.7		 5nzwA-2vw8A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		3 / 3 GLY A 146
LEU A  29
HIS A 149
 None
 0.58A 5u63A-2vw8A:
undetectable		 5u63A-2vw8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		3 / 3 GLY A 146
LEU A  29
HIS A 149
 None
 0.58A 5u63B-2vw8A:
undetectable		 5u63B-2vw8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		3 / 3 THR A  68
GLU A  38
HIS A 221
 None
None
FE2  A 401 ( 3.4A)
 0.83A 5xioA-2vw8A:
undetectable		 5xioA-2vw8A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		3 / 3 THR A  68
GLU A  38
HIS A 221
 None
None
FE2  A 401 ( 3.4A)
 0.82A 5xiqB-2vw8A:
undetectable		 5xiqB-2vw8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		3 / 3 THR A  68
GLU A  38
HIS A 221
 None
None
FE2  A 401 ( 3.4A)
 0.77A 5xiqD-2vw8A:
undetectable		 5xiqD-2vw8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2vw8 PA1000
(Pseudomonas
aeruginosa) 		4 / 8 HIS A  71
ASP A  73
HIS A 159
HIS A 221
 FE2  A 402 ( 3.2A)
FE2  A 401 ( 2.8A)
FE2  A 402 ( 3.3A)
FE2  A 401 ( 3.4A)
 0.93A 5zj8A-2vw8A:
17.3		 5zj8A-2vw8A:
23.55