SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vwb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLU A 437
ILE A 396
PRO A 397
ALA A 398
ILE A 465
 None
 1.23A 1aj6A-2vwbA:
undetectable		 1aj6A-2vwbA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A 103
GLU A   7
GLN A  75
GLY A   5
GLY A 286
 None
 1.06A 1mxgA-2vwbA:
1.7		 1mxgA-2vwbA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A 483
LYS A 472
ARG A 383
 None
 1.17A 1ra8A-2vwbA:
undetectable		 1ra8A-2vwbA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 4 SER A 379
ILE A 376
VAL A 192
THR A 453
 None
 1.06A 1u70A-2vwbA:
undetectable		 1u70A-2vwbA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ARG A 332
ALA A 240
ILE A 197
THR A 235
LEU A 124
 None
 1.32A 2bjfA-2vwbA:
undetectable		 2bjfA-2vwbA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ARG A 380
GLY A 469
ASP A 467
ILE A 411
 None
 0.95A 2f9wA-2vwbA:
10.1
2f9wB-2vwbA:
10.0		 2f9wA-2vwbA:
18.69
2f9wB-2vwbA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 286
GLY A 103
ILE A 113
ALA A 109
HIS A 106
 None
None
None
None
ANP  A1531 (-3.4A)
 0.99A 2fk8A-2vwbA:
undetectable		 2fk8A-2vwbA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		3 / 3 SER A 455
HIS A 496
ASP A 500
 None
 0.74A 2wa2B-2vwbA:
undetectable		 2wa2B-2vwbA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 8 TYR A 226
LEU A 223
LEU A 202
ALA A 205
 None
 1.08A 2wekA-2vwbA:
undetectable		 2wekA-2vwbA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 259
LEU A 126
VAL A 135
ILE A 197
PHE A 199
 None
 1.29A 2weyA-2vwbA:
undetectable		 2weyA-2vwbA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 4 GLY A   5
GLY A 286
GLY A  14
GLY A  16
 None
 0.65A 3bogC-2vwbA:
undetectable		 3bogC-2vwbA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 4 GLY A   5
GLY A 286
GLY A  14
GLY A  16
 None
 0.58A 3bogD-2vwbA:
undetectable		 3bogD-2vwbA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		3 / 3 GLU A   7
HIS A 106
THR A   9
 None
ANP  A1531 (-3.4A)
None
 0.87A 3hkuA-2vwbA:
undetectable		 3hkuA-2vwbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 5 ILE A 197
ARG A 380
GLU A 236
GLU A 344
 None
 1.29A 3ny4A-2vwbA:
undetectable		 3ny4A-2vwbA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ASP A 467
GLY A 471
ILE A 448
ILE A 396
ILE A 465
 None
 0.98A 3s56B-2vwbA:
undetectable		 3s56B-2vwbA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 11 THR A  96
LEU A   6
VAL A  15
VAL A  89
PHE A  60
 None
 1.46A 3u9fN-2vwbA:
undetectable
3u9fO-2vwbA:
undetectable		 3u9fN-2vwbA:
17.13
3u9fO-2vwbA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A  14
THR A  29
ASN A 285
 None
 0.69A 3v4tD-2vwbA:
undetectable		 3v4tD-2vwbA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 484
ILE A 425
ILE A 435
VAL A 439
VAL A 513
 None
 1.23A 3w68C-2vwbA:
undetectable		 3w68C-2vwbA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 358
LYS A 360
PRO A 399
ILE A 416
ILE A 466
 None
 0.93A 4dtaA-2vwbA:
3.0		 4dtaA-2vwbA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 358
PRO A 399
ILE A 416
ILE A 466
 None
 0.70A 4dtaB-2vwbA:
8.9		 4dtaB-2vwbA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A   4
GLY A  16
PHE A  26
ASN A  27
ALA A  90
 None
 1.03A 4eb4A-2vwbA:
undetectable		 4eb4A-2vwbA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A   4
GLY A  16
PHE A  26
ASN A  27
ALA A  90
 None
 1.04A 4eb4B-2vwbA:
undetectable		 4eb4B-2vwbA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A   6
ILE A  68
VAL A  63
GLY A  16
 None
 0.82A 4eq4B-2vwbA:
undetectable		 4eq4B-2vwbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 5 PRO A 123
ASP A 122
ILE A 136
VAL A 321
 None
 1.08A 4hytA-2vwbA:
undetectable		 4hytA-2vwbA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 7 LYS A 489
ALA A 490
THR A 453
SER A 455
 None
 0.95A 4ikjA-2vwbA:
undetectable
4ikjB-2vwbA:
undetectable		 4ikjA-2vwbA:
11.80
4ikjB-2vwbA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 8 SER A 455
LYS A 489
ALA A 490
THR A 453
 None
 0.87A 4ikjA-2vwbA:
undetectable
4ikjB-2vwbA:
undetectable		 4ikjA-2vwbA:
11.80
4ikjB-2vwbA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 8 LYS A 489
ALA A 490
THR A 453
SER A 455
 None
 0.93A 4ikkA-2vwbA:
undetectable
4ikkB-2vwbA:
undetectable		 4ikkA-2vwbA:
11.80
4ikkB-2vwbA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 7 SER A 455
LYS A 489
ALA A 490
THR A 453
 None
 0.85A 4ikkA-2vwbA:
undetectable
4ikkB-2vwbA:
undetectable		 4ikkA-2vwbA:
11.80
4ikkB-2vwbA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A 106
GLY A 286
ILE A 289
 ANP  A1531 (-3.4A)
None
None
 0.56A 4k50A-2vwbA:
undetectable		 4k50A-2vwbA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A 106
GLY A 286
ILE A 289
 ANP  A1531 (-3.4A)
None
None
 0.60A 4k50I-2vwbA:
undetectable		 4k50I-2vwbA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A 167
PRO A 168
ARG A 180
 None
 0.65A 4klrB-2vwbA:
undetectable		 4klrB-2vwbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ARG A  91
ILE A 310
THR A 308
GLY A 103
 None
 1.01A 4l39A-2vwbA:
undetectable		 4l39A-2vwbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		3 / 3 TYR A 190
ARG A 368
SER A 229
 None
 1.11A 4lf7I-2vwbA:
1.8
4lf7J-2vwbA:
2.2		 4lf7I-2vwbA:
14.74
4lf7J-2vwbA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		3 / 3 TYR A 190
ARG A 368
SER A 229
 None
 1.11A 4lf8I-2vwbA:
1.8
4lf8J-2vwbA:
2.2		 4lf8I-2vwbA:
14.74
4lf8J-2vwbA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 12 TYR A 221
ALA A 227
TYR A 190
TYR A 226
SER A 222
 None
 1.29A 4mm4B-2vwbA:
undetectable		 4mm4B-2vwbA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 12 TYR A 221
ALA A 227
TYR A 190
TYR A 226
SER A 222
 None
 1.25A 4mm6A-2vwbA:
undetectable		 4mm6A-2vwbA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 11 TYR A 221
ALA A 227
TYR A 190
TYR A 226
SER A 222
 None
 1.27A 4mm9A-2vwbA:
undetectable		 4mm9A-2vwbA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A 483
LEU A 484
PHE A 487
 None
 0.63A 4pthA-2vwbA:
undetectable		 4pthA-2vwbA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 8 GLU A 478
ASP A 477
ARG A 516
TRP A 503
 None
 1.19A 4uhxA-2vwbA:
undetectable		 4uhxA-2vwbA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A 126
GLN A 134
VAL A 145
THR A 316
ILE A 108
 None
 1.21A 4uuuB-2vwbA:
undetectable		 4uuuB-2vwbA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A 122
VAL A 247
LEU A 239
THR A 235
ALA A 238
 None
 1.19A 4yhaA-2vwbA:
undetectable		 4yhaA-2vwbA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A 451
GLU A 384
SER A 493
 None
 0.74A 5bw4B-2vwbA:
undetectable		 5bw4B-2vwbA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 436
PHE A 506
HIS A 443
ASP A 483
LEU A 484
 None
 1.46A 5eeiA-2vwbA:
undetectable		 5eeiA-2vwbA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 5 THR A   9
HIS A  48
ALA A  10
ASP A 284
 None
None
ANP  A1531 ( 4.0A)
ANP  A1531 (-2.7A)
 1.14A 5mfxA-2vwbA:
undetectable		 5mfxA-2vwbA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ILE A  71
ALA A  90
LEU A  93
ILE A  56
 None
 0.88A 5mvmB-2vwbA:
2.2
5mvmC-2vwbA:
undetectable		 5mvmB-2vwbA:
9.96
5mvmC-2vwbA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_A_OQRA302_0
(SULFOTRANSFERASE)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 9 MET A 230
VAL A 154
LEU A 158
ILE A 152
ASP A 151
 None
None
ANP  A1531 (-4.8A)
None
None
 1.46A 5tixA-2vwbA:
0.9		 5tixA-2vwbA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A 284
HIS A  48
LEU A  83
GLY A  76
HIS A 106
 ANP  A1531 (-2.7A)
None
None
None
ANP  A1531 (-3.4A)
 1.43A 6exiD-2vwbA:
undetectable		 6exiD-2vwbA:
9.87