SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vwk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		5 / 12 ILE A  96
ILE A  54
ALA A  68
LEU A  85
LEU A  42
 None
 1.05A 1bsxA-2vwkA:
undetectable		 1bsxA-2vwkA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		5 / 12 ILE A  96
ILE A  54
ALA A  68
LEU A  85
LEU A  42
 None
 1.05A 1bsxB-2vwkA:
undetectable		 1bsxB-2vwkA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		5 / 12 ILE A 691
ASP A 718
THR A 697
ILE A 666
LEU A 670
 None
 1.11A 1dyiB-2vwkA:
undetectable		 1dyiB-2vwkA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		4 / 6 PHE A 258
LEU A 322
VAL A 278
VAL A 263
 None
 0.93A 1e7aB-2vwkA:
undetectable		 1e7aB-2vwkA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		3 / 3 LEU A 571
PRO A 572
LEU A 575
 None
 0.54A 1hrkA-2vwkA:
undetectable		 1hrkA-2vwkA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		5 / 12 THR A 523
TYR A 520
ILE A 412
TYR A 494
THR A 541
 None
None
None
None
SO4  A1781 (-3.6A)
 1.10A 1jtxA-2vwkA:
undetectable		 1jtxA-2vwkA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		4 / 8 TRP A 355
GLY A 350
TYR A 496
SER A 348
 None
None
None
SO4  A1779 (-2.7A)
 1.10A 1maaD-2vwkA:
undetectable		 1maaD-2vwkA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		4 / 8 ILE A 693
TYR A 673
ILE A 666
GLU A 664
 None
 0.88A 1mrjA-2vwkA:
undetectable		 1mrjA-2vwkA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		4 / 7 LEU A  42
ILE A  48
ALA A  40
ILE A  96
 None
 0.82A 1oniB-2vwkA:
undetectable
1oniC-2vwkA:
undetectable		 1oniB-2vwkA:
10.66
1oniC-2vwkA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		4 / 8 TYR A 538
ASP A 540
ASP A 542
LEU A 608
 None
 0.90A 1pk2A-2vwkA:
undetectable		 1pk2A-2vwkA:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		3 / 3 ASP A 141
TYR A 209
GLU A 276
 None
 0.77A 1vm1A-2vwkA:
undetectable		 1vm1A-2vwkA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		5 / 12 ILE A  96
ILE A  54
ALA A  68
LEU A  85
LEU A  42
 None
 0.99A 2h79A-2vwkA:
undetectable		 2h79A-2vwkA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		4 / 8 TYR A 731
TRP A 615
TYR A 732
TYR A 701
 None
 1.12A 2ha2A-2vwkA:
undetectable		 2ha2A-2vwkA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		4 / 8 TYR A 731
TRP A 615
TYR A 732
TYR A 701
 None
 1.14A 2ha2B-2vwkA:
undetectable		 2ha2B-2vwkA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		4 / 6 LEU A 650
VAL A 636
VAL A 741
ILE A 642
 None
 0.96A 2hyyA-2vwkA:
undetectable		 2hyyA-2vwkA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		4 / 7 PHE A 405
LEU A 571
PRO A 435
GLU A 522
 None
 0.87A 2jn3A-2vwkA:
undetectable		 2jn3A-2vwkA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PK4_A_ACAA100_1
(HUMAN PLASMINOGEN
KRINGLE 4)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		4 / 7 ASP A 141
ASP A 315
PHE A 214
ARG A 694
 None
 1.37A 2pk4A-2vwkA:
undetectable		 2pk4A-2vwkA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		5 / 12 ALA A 539
ILE A 567
LEU A 571
PRO A 572
PHE A 405
 None
 1.25A 2qk8A-2vwkA:
undetectable		 2qk8A-2vwkA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XUD_A_DMEA1544_1
(ACETYLCHOLINESTERASE)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		4 / 6 TYR A 731
TRP A 615
TYR A 732
TYR A 701
 None
 1.11A 2xudA-2vwkA:
undetectable		 2xudA-2vwkA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		3 / 3 SER A 492
GLU A 330
ASP A 259
 None
 0.55A 2zulA-2vwkA:
undetectable		 2zulA-2vwkA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		3 / 3 SER A 492
GLU A 330
ASP A 259
 None
 0.51A 3dmhA-2vwkA:
undetectable		 3dmhA-2vwkA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		5 / 12 ILE A 618
VAL A 737
ILE A 733
GLU A 730
VAL A 655
 None
 1.03A 3fpjB-2vwkA:
undetectable		 3fpjB-2vwkA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		5 / 12 THR A 301
LEU A 670
VAL A 682
ILE A 666
THR A 697
 None
 1.30A 3frqA-2vwkA:
undetectable		 3frqA-2vwkA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		5 / 12 ILE A  96
ILE A  54
ALA A  68
LEU A  85
LEU A  42
 None
 0.98A 3gwsX-2vwkA:
undetectable		 3gwsX-2vwkA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		4 / 7 ASP A 141
ASP A 315
PHE A 214
ARG A 694
 None
 1.45A 3kivA-2vwkA:
undetectable		 3kivA-2vwkA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O0M_A_ACTA146_0
(HIT FAMILY PROTEIN)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		4 / 4 ASP A 635
GLU A 637
GLU A 638
ARG A 641
 None
 0.81A 3o0mA-2vwkA:
0.3		 3o0mA-2vwkA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		4 / 6 VAL A 682
TYR A 701
GLU A 664
ILE A 666
 None
 1.00A 3q5sA-2vwkA:
undetectable		 3q5sA-2vwkA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		3 / 3 LEU A 571
PRO A 572
LEU A 575
 None
 0.47A 3w1wB-2vwkA:
undetectable		 3w1wB-2vwkA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		5 / 12 PHE A 545
LEU A 627
ILE A 744
ALA A 595
THR A 605
 None
 1.10A 4enhA-2vwkA:
undetectable		 4enhA-2vwkA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		4 / 6 TYR A 279
LEU A 260
GLU A 325
ALA A 331
 None
 1.10A 4nkvC-2vwkA:
undetectable		 4nkvC-2vwkA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		4 / 6 LEU A 577
GLU A 576
ASN A 568
ILE A 567
 None
 0.94A 4ww7A-2vwkA:
undetectable		 4ww7A-2vwkA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		5 / 12 ILE A 488
ALA A 485
MET A 329
ALA A 331
ARG A 335
 None
 1.47A 4zo1X-2vwkA:
undetectable		 4zo1X-2vwkA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		3 / 3 TYR A 538
LYS A 592
LYS A 591
 None
SO4  A1781 (-3.4A)
SO4  A1781 (-3.3A)
 1.28A 5dbyA-2vwkA:
undetectable		 5dbyA-2vwkA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		3 / 3 VAL A 643
GLU A 730
GLU A 734
 None
 0.89A 5jsdB-2vwkA:
1.4
5jsdC-2vwkA:
1.3		 5jsdB-2vwkA:
22.78
5jsdC-2vwkA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		5 / 12 GLU A 458
GLY A 454
ILE A 413
ALA A 490
ASP A 455
 None
 1.06A 5kvaA-2vwkA:
undetectable		 5kvaA-2vwkA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		5 / 12 GLU A 458
GLY A 454
ILE A 413
ALA A 490
ASP A 455
 None
 1.07A 5kvaB-2vwkA:
undetectable		 5kvaB-2vwkA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		5 / 10 TYR A 112
ILE A 109
ILE A  38
ILE A  96
ILE A  54
 None
 1.09A 5murE-2vwkA:
3.1		 5murE-2vwkA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		6 / 12 PHE A 405
LEU A 564
ASN A 568
PHE A 544
ILE A 412
LEU A 408
 None
 1.47A 6dwnC-2vwkA:
0.0		 6dwnC-2vwkA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		3 / 3 HIS A 725
ARG A 685
ILE A 715
 None
 0.67A 6fgdA-2vwkA:
undetectable		 6fgdA-2vwkA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 2vwk DNA POLYMERASE
(Thermococcus
gorgonarius) 		4 / 7 ARG A 685
ALA A 683
ILE A 715
ALA A 714
 None
 0.94A 6ma7A-2vwkA:
undetectable		 6ma7A-2vwkA:
7.29